Table 6 Cox regression on retention for monotherapy versus individual combination therapies

Group

 PBO

–

–

–

–

–

–

 Li

1.11 (1.11)

0.53 (0.52)

2.11 (2.14)

0.035* (0.033)

3.04 (3.04)

1.08–8.57 (1.10–8.43)

 QTP

0.27 (0.17)

0.58 (0.59)

0.46 (0.29)

0.644 (0.773)

1.31 (1.18)

0.42–4.06 (0.38–3.73)

Side effect

0.08 (0.09)

0.11 (0.11)

0.76 (0.78)

0.448 (.435)

1.09 (1.09)

0.88–1.35 (0.88–1.35)

Side effect severity × Li

− 0.05 (− 0.04)

0.12 (0.13)

− 0.43 (− 0.33)

0.666 (0.742)

0.95 (0.96)

0.75–1.21 (0.75–1.23)

Side effect severity × QTP

− 0.03 (− 0.03)

0.11 (0.11)

− 0.30 (− 0.29)

0.763 (0.769)

0.97 (0.97)

0.77–1.21 (0.78–1.21)

YMRS

0.00 (0.00)

0.03 (0.03)

0.11 (0.84)

0.914 (0.933)

1.00 (1.00)

0.95–1.06 (0.95–1.06)

HAM-D

0.06 (0.06)

0.04 (0.04)

1.64 (1.59)

0.101 (0.113)

1.06 (1.06)

0.99–1.14 (0.99–1.14)

Site

− 0.68

1.06

− 0.64

0.521

0.51

0.06–4.06