Table 7 Cox regression on retention for monotherapy versus aggregated combination therapies

Group

 Monotherapy

–

–

–

–

–

–

 Combination therapy

0.93 (0.92)

0.48 (0.48)

1.94 (1.90)

0.052 (0.058)

2.56 (2.51)

0.99–6.61 (0.97–6.50)

Side effect severity

0.02 (0.02)

0.08 (0.09)

0.27 (0.27)

0.785 (0.785)

1.02 (1.02)

0.87–1.21 (0.86–1.21)

Side effect severity × group

0.01 (0.00)

0.09 (0.09)

− 0.43 (0.01)

0.939 (0.992)

1.01 (1.00)

0.85–1.20 (0.84–1.19)

YMRS

0.00 (− 0.00)

0.03 (0.03)

0.04 (− 0.03)

0.965 (0.973)

1.00 (1.00)

0.95–1.06 (0.95–1.05)

HAM-D

0.06 (0.07)

0.03 (0.03)

1.74 (2.06)

0.082 (0.039*)

1.06 (1.07)

0.99–1.14 (1.00–1.14)

Site

− 1.02

1.05

− 0.97

0.334

0.36

0.05–2.85