Probands (N = 214) | BPD onset < 21 yrs (n = 30) | BPD onset > 21 yrs (n = 51) | MDD onset < 21 yrs (n = 21) | MDD onset > 21 yrs (n = 47) | Comparison (n = 65) | Statistic | p |
---|---|---|---|---|---|---|---|
Socio-demographic factors | |||||||
Age (yrs), mean (s.d.) | 38.3 (7.3) | 41.5 (6.0) | 37.9 (5.5) | 42.4 (7.8) | 41.1 (6.8) | F4 = 2.7 | 0.032 |
Female, % | 60.0 | 54.9 | 71.4 | 53.2 | 43.1 | χ24 = 6.1 | n.s |
Socio-economic status, mean (s.d.)a | 3.0 (1.1) | 3.3 (1.0) | 2.8 (1.1) | 2.8 (1.0) | 3.4 (1.1) | F4 = 2.8 | 0.025 |
Non-mood disorders at baseline, % | |||||||
Any anxiety disordersb | 30.0 | 29.4 | 47.6 | 42.6 | 6.2 | χ24 = 24.9 | < 0.001 |
Alcohol abuse or dependence | 26.7 | 27.5 | 33.3 | 51.1 | 9.2 | χ24 = 24.3 | < 0.001 |
Illicit substance abuse or dependence | 23.3 | 17.7 | 9.5 | 19.2 | 7.7 | χ24 = 5.8 | n.s |
Spouses (N = 193) | Spouses of probands with BPD onset < 21 yrs (n = 27) | Spouses of probands with BPD onset > 21 yrs (n = 46) | Spouses of probands with MDD onset < 21 yrs (n = 17) | Spouses of probands with MDD onset > 21 yrs (n = 42) | Spouses of comparison probands (n = 61) | ||
---|---|---|---|---|---|---|---|
Socio-demographic factors | |||||||
Age (yrs), mean (s.d.) | 40.8 (9.0) | 43.1 (7.7) | 44.3 (8.0) | 42.4 (6.2) | 43.1 (7.9) | F4 = 0.7 | n.s |
Femalec, % | 40.0 | 45.1 | 28.6 | 46.8 | 56.9 | χ24 = 6.1 | n.s |
Interviewedc (%) | 50.0 | 60.8 | 42.9 | 53.2 | 66.2 | χ24 = 5.1 | n.s |
Spouse’s disorders at baseline, % | |||||||
Any bipolar disorder | 11.1 | 6.5 | 5.9 | 9.5 | 1.6 | χ24 = 4.1 | n.s |
Any depressive disorder | 22.2 | 34.8 | 41.2 | 28.6 | 29.5 | χ24 = 2.3 | n.s |
Any anxiety disordersb | 29.6 | 10.9 | 17.7 | 23.8 | 14.8 | χ24 = 5.4 | n.s |
Alcohol abuse or dependence | 18.5 | 23.9 | 35.3 | 23.8 | 6.6 | χ24 = 10.6 | < 0.05 |
Illicit substance abuse or dependence | 7.4 | 4.4 | 0 | 11.9 | 3.3 | χ24 = 5.0 | n.s |
Offspring (N = 388) | Offspring of probands with BPD onset < 21 yrs (n = 52) | Offspring of probands with BPD onset > 21 yrs (n = 95) | Offspring of probands with MDD onset < 21 yrs (n = 40) | Offspring of probands with MDD onset > 21 yrs (n = 82) | Offspring of comparison probands (n = 119) | ||
---|---|---|---|---|---|---|---|
Socio-demographic factors | |||||||
Age at first follow-up (yrs), mean (s.d.) | 8.6 (5.1) | 10.9 (4.1) | 8.8 (3.4) | 10.7 (3.9) | 9.3 (4.8) | F4 = 2.2 | n.s |
Age at last follow-up (yrs), mean (s.d.) | 21.6 (7.3) | 26.7 (5.6) | 21.7 (4.4) | 23.5 (6.4) | 23.6 (6.8) | F4 = 4.0 | 0.004 |
Girls, % | 61.5 | 47.4 | 67.5 | 45.1 | 46.2 | χ24 = 9.4 | n.s |
Number of assessments (%) | 4.9 (1.7) | 5.6 (1.6) | 4.7 (1.1) | 4.7 (1.6) | 5.4 (1.6) | F4 = 6.0 | < 0.001 |
Number of direct interviews (%) | 3.8 (1.8) | 4.8 (1.9) | 3.9 (1.4) | 3.8 (1.8) | 4.2 (1.9) | F4 = 4.3 | < 0.01 |
Duration of follow-up [yrs], mean (s.d.) | 13.0 (5.2) | 15.8 (4.5) | 12.9 (3.3) | 12.8 (4.1) | 14.3 (4.7) | F4 = 6.7 | < 0.001 |