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Table 2 Sample characteristics

From: Environmental factors in offspring of parents with mood disorders and their role in parent–child transmission: findings from a 14-year prospective high-risk study

Probands (N = 214)

BPD onset < 21 yrs (n = 30)

BPD onset > 21 yrs (n = 51)

MDD onset < 21 yrs (n = 21)

MDD onset > 21 yrs (n = 47)

Comparison (n = 65)

Statistic

p

Socio-demographic factors

 Age (yrs), mean (s.d.)

38.3 (7.3)

41.5 (6.0)

37.9 (5.5)

42.4 (7.8)

41.1 (6.8)

F4 = 2.7

0.032

 Female, %

60.0

54.9

71.4

53.2

43.1

χ24 = 6.1

n.s

 Socio-economic status, mean (s.d.)a

3.0 (1.1)

3.3 (1.0)

2.8 (1.1)

2.8 (1.0)

3.4 (1.1)

F4 = 2.8

0.025

Non-mood disorders at baseline, %

 Any anxiety disordersb

30.0

29.4

47.6

42.6

6.2

χ24 = 24.9

< 0.001

 Alcohol abuse or dependence

26.7

27.5

33.3

51.1

9.2

χ24 = 24.3

< 0.001

 Illicit substance abuse or dependence

23.3

17.7

9.5

19.2

7.7

χ24 = 5.8

n.s

Spouses (N = 193)

Spouses of probands with BPD onset < 21 yrs (n = 27)

Spouses of probands with BPD onset > 21 yrs (n = 46)

Spouses of probands with MDD onset < 21 yrs (n = 17)

Spouses of probands with MDD onset > 21 yrs (n = 42)

Spouses of comparison probands (n = 61)

  

Socio-demographic factors

 Age (yrs), mean (s.d.)

40.8 (9.0)

43.1 (7.7)

44.3 (8.0)

42.4 (6.2)

43.1 (7.9)

F4 = 0.7

n.s

Femalec, %

40.0

45.1

28.6

46.8

56.9

χ24 = 6.1

n.s

Interviewedc (%)

50.0

60.8

42.9

53.2

66.2

χ24 = 5.1

n.s

Spouse’s disorders at baseline, %

 Any bipolar disorder

11.1

6.5

5.9

9.5

1.6

χ24 = 4.1

n.s

 Any depressive disorder

22.2

34.8

41.2

28.6

29.5

χ24 = 2.3

n.s

 Any anxiety disordersb

29.6

10.9

17.7

23.8

14.8

χ24 = 5.4

n.s

 Alcohol abuse or dependence

18.5

23.9

35.3

23.8

6.6

χ24 = 10.6

< 0.05

 Illicit substance abuse or dependence

7.4

4.4

0

11.9

3.3

χ24 = 5.0

n.s

Offspring (N = 388)

Offspring of probands with BPD onset < 21 yrs (n = 52)

Offspring of probands with BPD onset > 21 yrs (n = 95)

Offspring of probands with MDD onset < 21 yrs (n = 40)

Offspring of probands with MDD onset > 21 yrs (n = 82)

Offspring of comparison probands (n = 119)

  

Socio-demographic factors

 Age at first follow-up (yrs), mean (s.d.)

8.6 (5.1)

10.9 (4.1)

8.8 (3.4)

10.7 (3.9)

9.3 (4.8)

F4 = 2.2

n.s

 Age at last follow-up (yrs), mean (s.d.)

21.6 (7.3)

26.7 (5.6)

21.7 (4.4)

23.5 (6.4)

23.6 (6.8)

F4 = 4.0

0.004

 Girls, %

61.5

47.4

67.5

45.1

46.2

χ24 = 9.4

n.s

 Number of assessments (%)

4.9 (1.7)

5.6 (1.6)

4.7 (1.1)

4.7 (1.6)

5.4 (1.6)

F4 = 6.0

< 0.001

 Number of direct interviews (%)

3.8 (1.8)

4.8 (1.9)

3.9 (1.4)

3.8 (1.8)

4.2 (1.9)

F4 = 4.3

< 0.01

 Duration of follow-up [yrs], mean (s.d.)

13.0 (5.2)

15.8 (4.5)

12.9 (3.3)

12.8 (4.1)

14.3 (4.7)

F4 = 6.7

< 0.001

  1. BPD bipolar disorder, MDD major depressive disorder, yrs years, sd standard deviation, n.s. not statistically significant
  2. aA value of 3 represents an SES of III (middle class) on the Hollingshead Scale
  3. bIncludes generalized anxiety disorder, social phobia, panic disorder, or agoraphobia
  4. cThis information was derived for 21 spouses with otherwise missing data