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Table 3 Individual or familial environmental factors according to offspring by proband mood disorder status

From: Environmental factors in offspring of parents with mood disorders and their role in parent–child transmission: findings from a 14-year prospective high-risk study

 

Proband diagnostic status

BPD onset < 21 yrs

BPD onset > 21 yrs

MDD onset < 21 yrs

MDD onset > 21 yrs

Comparison

%/m (SD)

ORa or βa (95% CI)

%/m (SD)

ORa or βa (95% CI)

%/m (SD)

ORa or βa (95% CI)

%/m (SD)

ORa or βa (95% CI)

%/m (SD)

Childhood adversity

 Traumatic events (N = 388)

21.2

OR = 2.0 (0.7, 5.4)

28.4

OR = 2.5* (1.1, 5.5)

30.0

OR = 3.2* (1.1, 9.4)

24.4

OR = 2.6* (1.0, 6.8)

10.9

Family environment

 Parental separation (N = 388)

69.2

OR = 3.1** (1.4, 6.9)

76.8

OR = 5.2*** (2.6, 10.3)

75.0

OR = 3.5* (1.3, 9.1)

67.1

OR = 3.5** (1.7, 7.4)

40.3

 Family cohesion (N = 224)

31.4 (8.7)

β = − 5.3** (− 8.9, − 1.7)

35.2 (7.4)

β = − 0.8 (− 3.3, 1.8)

34.3 (7.1)

β = − 0.0 (− 4.1, 4.1)

32.8 (7.8)

β = − 3.1° (− 6.3, 0.2)

36.3 (7.6)

Parental attitudes

 Proband (N = 221)

  Care

25.7 (7.5)

β = − 5.0*** (− 7.7, − 2.4)

28.8 (6.2)

β = − 1.3 (− 3.3,0.7)

29.4 (4.3)

β = − 0.9 (− 4.1,2.2)

28.4 (6.4)

β = − 1.6 (− 4.1,0.9)

29.8 (5.2)

  Denial of autonomy

6.1 (4.5)

β = 1.0 (− 0.9, 2.8)

3.9 (3.2)

β = − 1.4* (− 2.7, − 0.1)

5.8 (3.2)

β = 0.0 (− 2.1, 2.1)

5.7 (4.4)

β = − 0.3 (− 2.0, 1.4)

5.4 (3.9)

  Encouragement of freedom

12.2 (4.0)

β = − 0.4 (− 2.0, 1.3)

12.9 (3.2)

β = 0.6 (− 0.6, 1.8)

13.3 (3.2)

β = 0.7 (− 1.2, 2.6)

12.6 (3.9)

β = 0.3 (− 1.2, 1.8)

12.1 (3.6)

 Spouse (N = 223)

  Care

26.3 (8.4)

β = − 4.1** (− 7.2, − 1.0)

26.9 (6.6)

β = − 2.7* (− 5.0, − 0.4)

29.5 (5.7)

β = − 0.6 (− 4.2, 3.0)

28.6 (6.3)

β = − 0.8 (− 3.7, 2.1)

29.3 (6.6)

  Denial of autonomy

5.1 (3.5)

β = − 0.4 (− 2.2, 1.4)

3.9 (3.4)

β = − 1.6* (− 3.0, − 0.3)

6.4 (4.5)

β = 1.3 (− 0.8, 3.4)

5.0 (4.1)

β = − 0.3 (− 2.0, 1.4)

6.0 (4.1)

  Encouragement of freedom

12.5 (4.2)

β = − 0.2 (− 1.7, 1.4)

12.3 (3.4)

β = − 0.4 (− 1.5, 0.8)

12.0 (4.0)

β = − 1.0 (− 2.8, 0.8)

13.7 (3.0)

β = 1.2 (− 0.2, 2.7)

12.2 (3.1)

  1. Statistically significant values are in bold
  2. BPD bipolar disorder, MDD major depressive disorder, yrs years, m mean score, SD standard deviation, OR odd ratio, β beta estimate, 95% CI 95% confidence intervals
  3. aModels adjusted for sex, age and number of assessments in offspring, sex and age in proband, socio-economic status of the family, proband non-mood disorders and spouse mood and non-mood disorders (one single model for each outcome variable, imputed for missing spouse disorders)
  4. ***p < 0.001
  5. **p < 0.01
  6. *p < 0.05
  7. °p < 0.1