From: Differences between bipolar disorder types 1 and 2 support the DSM two-syndrome concept
Measure | Measure or Percentage [95%CI] | RR | p-value | |
---|---|---|---|---|
BD-1 | BD-2 | (BD-1/BD-2) | [t or χ2] | |
Subjects (n) | 657 | 720 | 1/1.10 | – |
Sex (%) | 0.06 [3.66] | |||
Women | 54.3 [50.4–58.2] | 59.4 [55.8–63.1] | 1/1.09 | |
Men | 45.7 [41.8–49.6] | 40.6 [36.9–44.2] | 1.13 | |
Family history (%) | ||||
Mood disorders | 60.2 [55.8–64.4] | 68.4 [64.4–72.2] | 1/1.14 | 0.005 [8.04] |
Bipolar disorder | 32.6 [28.6–36.8] | 30.8 [27.1–34.9] | 1.06 | 0.54 [0.38] |
Suicide | 9.12 [6.85–11.9] | 8.81 [6.69–11.3] | 1.04 | 0.85 [0.04] |
Ages or durations (years) | ||||
First symptoms | 22.4 [21.0–23.8] | 27.6 [25.7–29.4] | 1/1.23 | < 0.0001 [4.24] |
Syndromal onset | 25.6 [24.8–26.4] | 30.3 [29.3–31.4] | 1/1.18 | < 0.0001 [7.03] |
First diagnosis | 27.4 [26.0–28.8] | 33.7 [31.8–35.6] | 1/1.23 | < 0.0001 [5.04] |
First treatment | 27.9 [26.6–29.2] | 33.5 [32.0–35.1] | 1/1.20 | < 0.0001 [5.09] |
Symptoms to treatment | 5.72 [4.50–6.95] | 6.86 [5.67–8.04] | 1/1.20 | 0.19 [1.30] |
First suicide attempt | 33.2 [31.0–35.4] | 36.9 [34.1–39.7] | 1/1.11 | 0.04 [2.07] |
Illness duration | 17.1 [15.9–18.1] | 18.1 [17.1–19.1] | 1/1.06 | 0.17 [1.38] |
Current age | 43.2 [42.0–44.4] | 48.4 [47.2–49.6] | 1/1.12 | < 0.0001 [6.09] |
Socioeconomic status (%) | ||||
Educated > high school | 19.7 [16.5–23.1] | 28.3 [24.8–32.01] | 1/1.44 | 0.0004 [12.4] |
Unemployeda | 16.5 [13.7–19.7] | 9.01 [6.96–11.4] | 1.83 | < 0.0001 [16.7] |
Low SES rankingb | 17.9 [13.7–22.8] | 5.32 [3.23–8.19] | 3.36 | < 0.0001 [18.8] |
Marital history | ||||
Ever married (%)c | 38.8 [35.0–42.6] | 53.2 [49.4–57.0] | 1/1.37 | < 0.0001 [28.5] |
Ever separated (%) | 17.9 [13.9–22.6] | 14.7 [11.6–18.4] | 1.22 | 0.24 [1.41] |
Children (n/person) | 0.80 [0.70–0.90] | 1.10 [1.00–1.21] | 1/1.38 | < 0.0001 [4.11] |
Temperament scores | ||||
Anxious | 1.14 [0.95–1.33] | 1.36 [1.21–1.51] | 1/1.19 | 0.07 [1.80] |
Cyclothymic | 5.21 [4.69–5.73] | 6.06 [5.64–6.48] | 1/1.16 | 0.01 [2.49] |
Dysthymic | 3.15 [2.81–3.49] | 3.49 [3.21–3.77] | 1/1.11 | 0.13 [1.51] |
Hyperthymic | 3.55 [3.20–3.90] | 3.65 [2.78–4.52] | 1/1.03 | 0.66 [0.44] |
Irritable | 1.84 [1.55–2.13] | 1.85 [1.59–2.11] | 1/1.01 | 0.98 [0.03] |
Bodyweight | ||||
BMI (kg/m2) | 25.0 [24.5–25.5] | 24.3 [23.8–247] | 1.03 | 0.04 [2.06] |
Obese (%)d | 21.7 [15.9–28.4] | 10.7 [6.35–16.6] | 2.03 | 0.007 [7.37] |