Table 3 Comparison of HDRS item scores with bipolar-1 vs. bipolar-2 subjects
From: Differences between bipolar disorder types 1 and 2 support the DSM two-syndrome concept
Number | Item | Mean score [95%CI] | RR | t-score | p-value | |
|---|---|---|---|---|---|---|
Bipolar-1 | Bipolar-2 | |||||
1 | Depressed mood | 1.98 [1.87–2.10] | 2.28 [2.19–2.36] | 0.860 | 4.23 | < 0.0001 |
2 | Guilt | 0.985 [0.889–1.08] | 1.27 [1.19–1.35] | 0.774 | 4.55 | < 0.0001 |
3 | Suicidal | 0.579 [0.490–0.658] | 0.771 [0.696–0.846] | 0.754 | 3.38 | 0.0008 |
4 | Early insomnia | 0.458 [0.386–0.530] | 0.660 [0.594–0.726] | 0.691 | 4.01 | < 0.0001 |
5 | Middle insomnia | 0.435 [0.369–0.501] | 0.568 [0.509–0.628] | 0.764 | 2.92 | 0.004 |
6 | Early awakening | 0.432 [0.362–0.503] | 0.635 [0.571–0.699] | 0.677 | 4.15 | < 0.0001 |
7 | Work and activities | 2.16 [2.03–2.29] | 2.19 [2.09–2.29] | 0.986 | 0.36 | 0.72 |
8 | Psychomotor retardation | 0.662 [0.587–0.740] | 0.490 [0.435–0.546] | 1.35 | 3.67 | 0.0003 |
9 | Agitation | 0.277 [0.221–0.333] | 0.414 [0.363–0.465] | 0.669 | 3.45 | 0.0006 |
10 | Psychic anxiety | 1.35 [1.24–1.46] | 1.91 [1.83–1.99] | 0.702 | 8.44 | < 0.0001 |
11 | Somatic anxiety | 0.405 [0.328–0.472] | 0.811 [0.730–0.891] | 0.493 | 7.01 | < 0.0001 |
12 | Loss of appetite | 0.366 [0.312–0.420] | 0.475 [0.428–0.522] | 0.771 | 2.98 | 0.003 |
13 | Fatigue | 1.21 [1.13–1.28] | 1.31 [1.25–1.37] | 0.924 | 2.04 | 0.05 |
14 | Anhedonia/genital symptoms | 0.884 [0.763–1.01] | 0.970 [0.900–1.04] | 0.907 | 1.28 | 0.18 |
15 | Hypochondriasis | 0.163 [0.113–0.212] | 0.323 [0.266–0.380] | 0.499 | 3.96 | < 0.0001 |
16 | Weight-loss | 0.310 [0.256–0.364] | 0.409 [0.357–0.461] | 0.758 | 2.55 | 0.01 |
17 | Insight | 0.090 [0.054–0.127] | 0.120 [0.088–0.153] | 0.750 | 1.19 | 0.23 |
18 | Circadian mood variation | 0.767 [0.689–0.845] | 0.987 [0.919–1.05] | 0.777 | 4.14 | < 0.0001 |
19 | Depersonalization/derealization | 0.077 [0.044–0.110] | 0.056 [0.035–0.076] | 1.38 | 1.14 | 0.26 |
20 | Paranoid | 0.597 [0.506–0.688] | 0.364 [0.307–0.421] | 1.64 | 4.49 | < 0.0001 |
21 | Obsessive–compulsive | 0.071 [0.039–0.102] | 0.102 [0.073–0.131] | 0.689 | 1.43 | 0.15 |
1–21 | Total score | 14.5 [13.7–15.2] | 17.4 [16.8–17.9] | 0.833 | 6.42 | < 0.0001 |