Efficacy and safety of adjunctive therapy to lamotrigine, lithium, or valproate monotherapy in bipolar depression: a systematic review and meta-analysis of randomized controlled trials

International Journal of Bipolar Disorders

Table 2 Summary of outcomes

Study (year)	Measure for depressive symptoms	Severity of depressive symptoms at baseline: score ± SD		Study duration weeks	Improvement in depressive symptoms score ± SD^a			Remission rate from depressive symptoms %
Study (year)	Measure for depressive symptoms	Intervention	Control	Study duration weeks	Intervention	Control	P value	Intervention	Control	P value
van der Loos (2009)	MADRS	28.25 ± 5.97	28.82 ± 6.24	8	− 15.38 ± 10.56	− 11.03 ± 10.53	0.024	46.9^a	30.0^a	0.0234
Houston (2009)	HDRS-21	22.45 ± 4.2	21.87 ± 4.9	6	− 9.37 ± 5.50	− 7.69 ± 5.43	0.022	31	26	0.437
Sachs (2011)	MADRS	30.0 ± 5.5	28.8 ± 6.1	6	− 13.2 ± 14.4	− 12.9 ± 13.2	0.7921	33.1	37.2	0.5029
Loebel (2014)	MADRS	30.6 ± 5.3	30.8 ± 4.8	6	− 17.1 ± 11.73	− 13.5 ± 11.73	0.005	50	35	0.008
Suppes (2016)	MADRS	29.1 ± 4.9	29.1 ± 4.7	6	− 11.8 ± 9.54	− 10.4 ± 9.54	0.176	34	28	0.227

HDRS-21, 21-item Hamilton Depression Rating Scale; MADRS, Montgomery-Åsberg Depression Rating Scale; SD, standard deviation
^aCalculated using the data in the paper