Table 2 Familial load (FL) of psychiatric disorders (PD) in patients newly diagnosed with bipolar disorder (BD) and their unaffected first-degree relatives (UR)
BD | UR | |
|---|---|---|
Number, N | 387 | 143 |
≥ 1 parent with PD | 194 (50.1%) | 62 (43.1%) |
≥ 1 sibling with PD | 104 (26.9%) | 135 (93.8%) |
≥ 1 offspring with PD | 13 (3.4%) | 4 (2.8%) |
≥ 1 first-degree relative with PD | 251 (64.9%) | 143 (100%) |
≥ 2 first-degree relatives with PD | 90 (23.3%) | 64 (45.1%) |
Number of first-degree relatives with PD | ||
0 | 136 (35.1%) | 0 |
1 | 161 (41.6%) | 79 (55.2%) |
2 | 66 (17.1%) | 53 (37.1%) |
3 | 22 (5.7%) | 10 (7.0%) |
4 | 0 | 1 (0.7%) |
5 | 1 (0.3%) | 0 |
6 | 1 (0.3%) | 0 |
First-degree relatives with PD | ||
Depression and/or suicide | 130 (33.5%) | 31 (21.5%) |
Bipolar disorder | 60 (15.5%) | 144 (100%)a |
Affective disorder, not other specified | 1 (0.3%) | 0 |
Schizophrenia | 6 (1.5%) | 1 (0.7%) |
Alcohol abuse | 48 (12.4%) | 16 (11.1%) |
Other known psychiatric disorder | 65 (16.8%) | 12 (8.3%) |
Suicide | ||
Consummated suicide in a first-degree relative | 9 (2.3%) | 6 (4.2%) |
Family Liability Index (FLI) | ||
FLI | 0.32 (0.30) | 0.45 (0.22) |