Familial load of psychiatric disorders and overall functioning in patients newly diagnosed with bipolar disorder and their unaffected first-degree relatives

Sletved, Kimie Stefanie Ormstrup; Maiggaard, Katrine; Thorup, Anne Amalie Elgaard; Kessing, Lars Vedel; Vinberg, Maj

doi:10.1186/s40345-022-00277-1

International Journal of Bipolar Disorders

Table 3 Associations between familial load of psychiatric disorders (PD) and the outcomes (1) Functioning Assessment Short Test (FAST) in total scores and subdomains, (2) Work and Social Adjustment scale (WSAS) and (3) Years of education in patients newly diagnosed with bipolar disorder (BD) and their unaffected first-degree relatives (UR).

From: Familial load of psychiatric disorders and overall functioning in patients newly diagnosed with bipolar disorder and their unaffected first-degree relatives

Patients newly diagnosed with BD (n = 388)				UR of patients newly diagnosed with BD (n = 144)
	B	95% CI	P		B	95% CI	P
FAST, total score
≥ 1 PD Relative	1.66	[− 0.67; 3.98]	0.162	≥ 2 PD Relatives	0.33	[− 2.62; 3.27]	0.828
FLI	2.31	[− 1.42; 6.04]	0.223	FLI	− 3.12	[− 9.69; 3.26]	0.328
FAST subdomains
Autonomy
≥ 1 PD Relative	0.32	[− 0.20; 0.85]	0.229	≥ 2 PD Relatives	0.16	[− 0.40; 0.72]	0.572
FLI	0.42	[− 0.42; 1.27]	0.325	FLI	− 0.30	[− 1.5; 0.94]	0.634
Occupation
≥ 1 PD Relative	0.55	[− 0.70; 1.81]	0.387	≥ 2 PD Relatives	− 0.55	[− 1.69; 0.60]	0.347
FLI	0.50	[− 1.51; 2.52]	0.623	FLI	− 2.07	[− 4.57; 0.44]	0.105
Cognition
≥ 1 PD Relative	0.21	[− 0.45; 0.87]	0.532	≥ 2 PD Relatives	− 0.16	[− 0.82; 0.51]	0.641
FLI	0.41	[− 0.65; 1.46]	0.449	FLI	− 0.99	[− 2.45; 0.46]	0.180
Finances
≥ 1 PD Relative	0.20	[− 0.18; 0.57]	0.299	≥ 2 PD Relatives	0.03	[− 0.24; 0.30]	0.824
FLI	0.08	[− 0.52; 0.67]	0.804	FLI	− 0.22	[− 0.80; 0.37]	0.461
Relations
≥ 1 PD Relative	0.28	[− 0.36; 0.91]	0.392	≥ 2 PD Relatives	0.58	[− 0.19; 1.36]	0.140
FLI	0.82	[− 0.20; 1.84]	0.113	FLI	0.01	[− 1.72; 1.73]	0.991
Leisure
≥ 1 PD Relative	0.10	[− 0.23; 0.43]	0.560	≥ 2 PD Relatives	0.26	[− 0.16; 0.67]	0.230
FLI	0.08	[− 0.45; 0.62]	0.759	FLI	0.35	[− 0.57; 1.23]	0.453
WSAS
≥ 1 PD Relative	− 0.04	[− 1.56; 1.50]	0.956	≥ 2 PD Relatives	1.14	[− 1.22; 3.50]	0.342
FLI	− 0.51	[− 2.96; 1.94]	0.683	FLI	0.74	[− 4.53; 6.00]	0.782
Education
≥ 1 PD Relative	− 0.15	[− 0.67; 0.38]	0.589	≥ 2 PD Relatives	− 0.17	[− 1.05; 0.72]	0.709
FLI	− 0.20	[− 1.05; 6.64]	0.639	FLI	0.89	[− 1.04; 2.82]	0.363

Analyses presented are adjusted to age, sex, HDRS-17 and YMRS
HDRS-17: Hamilton Depression Rating Scale, total score
YMRS: Young Mania Rating Scale, total score
FAST: Functioning Assessment Short Test
WSAS: Work and Social Adjustment Scale
Education: educational achievement measured in years
≥ 1 PD Relative: Participants with one or more first-degree relatives with psychiatric disorders
≥ 2 PD Relatives: Participants with two or more first-degree relatives with psychiatric disorders
FLI: Family Liability Index

Back to article page