Articles

Bipolar disorder and diabetes mellitus: evidence for disease-modifying effects and treatment implications

Bipolar disorder refers to a group of chronic psychiatric disorders of mood and energy levels. While dramatic psychiatric symptoms dominate the acute phase of the diseases, the chronic course is often determin...

Authors: Ellen F. Charles, Christophe G. Lambert and Berit Kerner

Repeated salivary daytime cortisol and onset of mood episodes in offspring of bipolar parents

Differences in cortisol secretion may differentiate individuals at high compared to low genetic risk for bipolar disorder (BD) and predict the onset or recurrence of mood episodes. The objectives of this study...

Authors: Sarah M. Goodday, Julie Horrocks, Charles Keown-Stoneman, Paul Grof and Anne Duffy

Toxoplasma gondii exposure may modulate the influence of TLR2 genetic variation on bipolar disorder: a gene–environment interaction study

Genetic vulnerability to environmental stressors is yet to be clarified in bipolar disorder (BD), a complex multisystem disorder in which immune dysfunction and infectious insults seem to play a major role in ...

Authors: José Oliveira, Rémi Kazma, Edith Le Floch, Meriem Bennabi, Nora Hamdani, Djaouida Bengoufa, Mehdi Dahoun, Céline Manier, Frank Bellivier, Rajagopal Krishnamoorthy, Jean-François Deleuze, Robert Yolken, Marion Leboyer and Ryad Tamouza

Big data for bipolar disorder

The delivery of psychiatric care is changing with a new emphasis on integrated care, preventative measures, population health, and the biological basis of disease. Fundamental to this transformation are big da...

Authors: Scott Monteith, Tasha Glenn, John Geddes, Peter C. Whybrow and Michael Bauer

Biological rhythms are independently associated with quality of life in bipolar disorder

Evidence suggests that patients with bipolar disorder (BD) experience biological rhythm disturbances; however, no studies have examined the impact of this disruption on quality of life (QOL). The aim of this s...

Authors: Lauren E. Cudney, Benicio N. Frey, David L. Streiner, Luciano Minuzzi and Roberto B. Sassi

The direct and indirect effects of lurasidone monotherapy on functional improvement among patients with bipolar depression: results from a randomized placebo-controlled trial

Bipolar depression is characterized by depressive symptoms and impairment in many areas of functioning, including work, family, and social life. The objective of this study was to assess the independent, direc...

Authors: Krithika Rajagopalan, Elizabeth Dansie Bacci, Kathleen W. Wyrwich, Andrei Pikalov and Antony Loebel

Development and validation of the BD S_X: a brief measure of mood and symptom variability for use with adults with bipolar disorder

Ecological momentary sampling in BD research requires brief symptom measures with low cognitive demands to maximize data collection across the range of BD symptomatology. We developed the BD S_x cognizant of the c...

Authors: Norm O’Rourke, Andrew Sixsmith, David B. King, Hamed Yaghoubi-Shahir and Sarah L. Canham

Behavioral and emotional adverse events of drugs frequently used in the treatment of bipolar disorders: clinical and theoretical implications

Behavioral and emotional adverse events induced by drugs commonly prescribed to patients with bipolar disorders are of paramount importance to clinical practice and research. However, no reviews on the topic h...

Authors: Alejandro Szmulewicz, Cecilia Samamé, Pablo Caravotta, Diego J. Martino, Ana Igoa, Diego Hidalgo-Mazzei, Francesc Colom and Sergio A. Strejilevich

Bipolar disorder and antithyroid antibodies: review and case series

Mood disorders and circulating thyroid antibodies are very prevalent in the population and their concomitant occurrence may be due to chance. However, thyroid antibodies have been repeatedly hypothesized to p...

Authors: Alberto Bocchetta, Francesco Traccis, Enrica Mosca, Alessandra Serra, Giorgio Tamburini and Andrea Loviselli

Harnessing the potential of community-based participatory research approaches in bipolar disorder

Despite the rapid growth in the sophistication of research on bipolar disorder (BD), the field faces challenges in improving quality of life (QoL) and symptom outcomes, adapting treatments for marginalized com...

Authors: Erin E. Michalak, Steven Jones, Fiona Lobban, Guillermo Perez Algorta, Steven J. Barnes, Lesley Berk, Michael Berk, Rachelle Hole, Sara Lapsley, Victoria Maxwell, Roumen Milev, John McManamy, Greg Murray, Mauricio Tohen, Samson Tse, Manuel Sanchez de Carmona…

Circadian rhythmicity in emerging mood disorders: state or trait marker?

Circadian rhythm disturbances overlap with the symptoms of mood episodes and may trigger or prolong mood symptoms. There is limited research on the role of circadian disturbances in mood disorders in young peo...

Authors: Ashlee B. Grierson, Ian B. Hickie, Sharon L. Naismith, Daniel F. Hermens, Elizabeth M. Scott and Jan Scott

The role of childhood trauma in bipolar disorders

This review will discuss the role of childhood trauma in bipolar disorders. Relevant studies were identified via Medline (PubMed) and PsycINFO databases published up to and including July 2015. This review con...

Authors: Monica Aas, Chantal Henry, Ole A. Andreassen, Frank Bellivier, Ingrid Melle and Bruno Etain

Lithium overdosage and related tests

Lithium acts biochemically through the inositol depletion in brain cortex. At low doses, however, it is partly effective and/or ineffective, whereas in high concentrations is toxic. We would like to make one p...

Authors: Paolo D. Pigatto, Bernardo Dell’Osso and Gianpaolo Guzzi

Will mania survive DSM-5 and ICD-11?

As a natural phenomenon, mania without major depression will of course survive DSM-5 and ICD-11, but following its integration as a diagnosis into bipolar-I disorder (BP-I) in those manuals, BP-I will be more ...

Authors: Jules Angst

Treatment of lithium intoxication: facing the need for evidence

Lithium has been used as the gold standard in the treatment of major depressive and bipolar disorders for decades. Due to its narrow therapeutic index, lithium toxicity is a common clinical problem. Although r...

Authors: R. Haussmann, M. Bauer, S. von Bonin, P. Grof and U. Lewitzka

Low self-recognition and awareness of past hypomanic and manic episodes in the general population

Bipolar disorder is often underdiagnosed and undertreated. Its detection and correct diagnosis highly relies on the report of past hypomanic or manic episodes. We investigated the recognition and awareness of ...

Authors: Eline J. Regeer, Ralph W. Kupka, Margreet ten Have, Wilma Vollebergh and Willem A. Nolen

Big data are coming to psychiatry: a general introduction

Big data are coming to the study of bipolar disorder and all of psychiatry. Data are coming from providers and payers (including EMR, imaging, insurance claims and pharmacy data), from omics (genomic, proteomi...

Authors: Scott Monteith, Tasha Glenn, John Geddes and Michael Bauer

Inflammatory monocyte gene expression: trait or state marker in bipolar disorder?

This study aimed to examine whether inflammatory gene expression was a trait or a state marker in patients with bipolar disorder (BD).

Authors: K. Becking, B. C. M. Haarman, R. F. Riemersma van der Lek, L. Grosse, W. A. Nolen, S. Claes, H. A. Drexhage and R. A. Schoevers

Do your patients with bipolar disorder use dietary supplements?

Authors: Peter C Whybrow and Tasha Glenn

Randomized, placebo-controlled, adjunctive study of armodafinil for bipolar I depression: implications of novel drug design and heterogeneity of concurrent bipolar maintenance treatments

Some, but not all, prior investigations suggest armodafinil may have utility as an adjunctive treatment in bipolar I depression.

Authors: Mark A Frye, Jess Amchin, Michael Bauer, Caleb Adler, Ronghua Yang and Terence A Ketter

Symptom severity of bipolar disorder during the menopausal transition

Little is known about the mood symptom experience of women with bipolar disorder during the menopausal transition (MT). Yet times of rapid hormonal decline, such as the postpartum, are associated with increase...

Authors: Wendy K. Marsh, Bernice Gershenson and Anthony J. Rothschild

Developmental staging models in bipolar disorder

The previous contribution of Duffy and colleagues suggests that a chain of behavioral events starting during childhood precedes the development of full-blown bipolar disorder. In this vein, the recent contribu...

Authors: Ives C Passos, Karen Jansen and Flavio Kapczinski

The suicide prevention effect of lithium: more than 20 years of evidence—a narrative review

The management and treatment of patients with suicidal behavior is one of the most challenging tasks for health-care professionals. Patients with affective disorders are at high risk for suicidal behavior, the...

Authors: U Lewitzka, E Severus, R Bauer, P Ritter, B Müller-Oerlinghausen and M Bauer

Development of a bipolar disorder biobank: differential phenotyping for subsequent biomarker analyses

We aimed to establish a bipolar disorder biobank to serve as a resource for clinical and biomarker studies of disease risk and treatment response. Here, we describe the aims, design, infrastructure, and resear...

Authors: Mark A Frye, Susan L McElroy, Manuel Fuentes, Bruce Sutor, Kathryn M Schak, Christine W Galardy, Brian A Palmer, Miguel L Prieto, Simon Kung, Christopher L Sola, Euijung Ryu, Marin Veldic, Jennifer Geske, Alfredo Cuellar-Barboza, Lisa R Seymour, Nicole Mori…

Lithium nephrotoxicity

Reports of toxic effects on the kidney of lithium treatment emerged very soon after lithium therapy was introduced. Lithium-induced nephrogenic diabetes insipidus is usually self-limiting or not clinically dan...

Authors: Abed N. Azab, Alla Shnaider, Yamima Osher, Dana Wang, Yuly Bersudsky and R. H. Belmaker

Common use of dietary supplements for bipolar disorder: a naturalistic, self-reported study

Dietary supplements are taken by about half of Americans. Knowledge of dietary supplement use is important because they may interact with prescription drugs or other supplements, cause adverse reactions includ...

Authors: Michael Bauer, Tasha Glenn, Jörn Conell, Natalie Rasgon, Wendy Marsh, Kemal Sagduyu, Rodrigo Munoz, Ute Lewitzka, Rita Bauer, Maximilian Pilhatsch, Scott Monteith and Peter C. Whybrow

Patterns of response to aripiprazole, lithium, haloperidol, and placebo across factor scores of mania

A previous factor analysis of Young Mania Rating Scale and Montgomery-Åsberg Depression Rating Scale items identified composite factors of depression, mania, sleep disturbance, judgment/impulsivity, and irrita...

Authors: Michael J Ostacher, Trisha Suppes, Alan C Swann, James M Eudicone, Wally Landsberg, Ross A Baker and Berit X Carlson

Validity and reliability of the Finnish version of the Functioning Assessment Short Test (FAST) in bipolar disorder

The Functioning Assessment Short Test (FAST) was developed for the clinical evaluation of functional impairment of patients suffering from bipolar disorder. The aim of this study was to validate the Finnish ve...

Authors: Kirsi Suominen, Elina Salminen, Susanna Lähteenmäki, Tiina Tupala and Erkki Isometsä

Cognitive impairment in first-episode mania: a systematic review of the evidence in the acute and remission phases of the illness

There is evidence of cognitive impairment that persists in the remission phase of bipolar disorder; however, the extent of the deficits that occur from the first onset of the disorder remains unclear. This is ...

Authors: Rothanthi Daglas, Murat Yücel, Sue Cotton, Kelly Allott, Sarah Hetrick and Michael Berk

Clinical characteristics of bipolar disorder: a comparative study between Argentina and the United States

Bipolar disorder presents with diverse clinical manifestations. Numerous investigators have sought to identify variables that may predict a more severe illness course.

Authors: Jessica N Holtzman, Maria Lolich, Terence A Ketter and Gustavo H Vázquez

Who will benefit from antidepressants in the acute treatment of bipolar depression? A reanalysis of the STEP-BD study by Sachs et al. 2007, using Q-learning

There is substantial uncertainty regarding the efficacy of antidepressants in the treatment of bipolar disorders.

Authors: Fan Wu, Eric B Laber, Ilya A Lipkovich and Emanuel Severus

The influence of life events on first and recurrent admissions in bipolar disorder

Life events play an important role in the onset and course of bipolar disorder. We will test the influence of life events on first and recurrent admissions in bipolar disorder and their interaction to test the...

Authors: Sanne M Kemner, Neeltje EM van Haren, Florian Bootsman, Marinus JC Eijkemans, Ronald Vonk, Astrid C van der Schot, Willem A Nolen and Manon HJ Hillegers

Multi-state models for investigating possible stages leading to bipolar disorder

It has been proposed that bipolar disorder onsets in a predictable progressive sequence of clinical stages. However, there is some debate in regard to a statistical approach to test this hypothesis. The object...

Authors: Charles DG Keown-Stoneman, Julie Horrocks, Gerarda A Darlington, Sarah Goodday, Paul Grof and Anne Duffy

Switch to mania after ayahuasca consumption in a man with bipolar disorder: a case report

There is an increasing use of ayahuasca for recreational purposes. Furthermore, there is a growing evidence for the antidepressant properties of its components. However, there are no reports on the effects of ...

Authors: Alejandro G Szmulewicz, Marina P Valerio and Jose M Smith

Impact of childhood trauma and affective temperament on resilience in bipolar disorder

The aim of this study was to investigate whether childhood trauma (CT) and affective temperament have an impact on resilience in bipolar patients.

Authors: Sermin Kesebir, Başak Ünübol, Elif Tatlıdil Yaylacı, Duru Gündoğar and Hüseyin Ünübol

Burden, reward, and coping of adult offspring of patients with depression and bipolar disorder

In previous years, research has focused on the situation of psychiatric patients' minor children. The aims of this qualitative study were to describe the experience of adult children of depressed and bipolar p...

Authors: Rita Bauer, Hermann Spiessl and Marina J Helmbrecht

More robust evidence for the efficacy of lithium in the long-term treatment of bipolar disorder: should lithium (again) be recommended as the single preferred first-line treatment?

With two recent systematic reviews and meta-analyses on the efficacy of lithium compared to placebo and other treatment options, it can now be concluded that lithium is the only drug that has been shown effica...

Authors: Willem A Nolen

Prophylactic lithium treatment and cognitive performance in patients with a long history of bipolar illness: no simple answers in complex disease-treatment interplay

Cognitive impairment in patients with bipolar disorder (BD) is not restricted to symptomatic phases. It is also present in euthymia. There is evidence of differences in the brain’s structure between bipolar pa...

Authors: Andrea Pfennig, Martin Alda, Trevor Young, Glenda MacQueen, Janusz Rybakowski, Aleksandra Suwalska, Christian Simhandl, Barbara König, Tomas Hajek, Claire O’Donovan, Dirk Wittekind, Susanne von Quillfeldt, Jana Ploch, Cathrin Sauer and Michael Bauer

Lithium for prevention of mood episodes in bipolar disorders: systematic review and meta-analysis

In a previous meta-analysis of randomized controlled trials comparing lithium with placebo as a long-term treatment in bipolar disorders, we observed a clear preventative effect for manic episodes; however, th...

Authors: Emanuel Severus, Matthew J Taylor, Cathrin Sauer, Andrea Pfennig, Philipp Ritter, Michael Bauer and John R Geddes

Lithium as add-on to quetiapine XR in adult patients with acute mania: a 6-week, multicenter, double-blind, randomized, placebo-controlled study

Quetiapine extended release (XR) and lithium are treatments with proven efficacy in acute mania. This randomized study evaluated the efficacy and safety of lithium or placebo as add-on to quetiapine XR in adul...

Authors: Michel S Bourin, Emanuel Severus, Juan P Schronen, Peter Gass, Johan Szamosi, Hans Eriksson and Hongally Chandrashekar

Every reason to discontinue lithium

Lithium as a gold standard therapy for bipolar disorder is well known to have a number of medical comorbidities that impact renal, parathyroid, and thyroid function. Despite these medical comorbidities, there ...

Authors: Manuel E Fuentes Salgado, Bruce Sutor, Robert C Albright and Mark A Frye

Compliance as a stable function in the treatment course of bipolar disorder in patients stabilized on olanzapine: results from a 24-month observational study

Compliance is a key factor in the maintenance treatment of bipolar disorder. This noninterventional study was conducted to explore factors associated with higher levels of compliance in bipolar patients, all t...

Authors: Alexandra Kutzelnigg, Martin Kopeinig, Chih-Ken Chen, Ágnes Fábián, María Gloria Pujol-Luna, Young-chul Shin, Tamás Treuer, Yulia D'yachkova, Claudia Deix, Siegfried Kasper and Dagmar Doby

Are rates of pediatric bipolar disorder increasing? Results from a nationwide register study

Studies from the USA suggest that rates of pediatric bipolar disorder have increased since the mid-90s, but no study outside the USA has been published on the rates of pediatric bipolar disorder. Further, it i...

Authors: Lars Vedel Kessing, Eleni Vradi and Per Kragh Andersen

Mood dynamics in bipolar disorder

The nature of mood variation in bipolar disorder has been the subject of relatively little research because detailed time series data has been difficult to obtain until recently. However some papers have addre...

Authors: Paul J Moore, Max A Little, Patrick E McSharry, Guy M Goodwin and John R Geddes

Letter to the editor: is it valid to break down results from long-term trials in bipolar disorder by polarity of relapses?

When analysing and reporting data from long-term drug trials in bipolar disorder, it has become the standard to break down the outcome into the prevention of mania and the prevention of depression. However, as...

Authors: Rasmus Wentzer Licht and Emanuel Severus

Mood regulation in bipolar disorders viewed through the pendulum dynamics concept

Bipolar disorders have been characterized by powerful fluctuations of energy, mood, and thinking patterns. Mood episodes (manic or depressive) could be considered as deviations of a psycho-physiological index ...

Authors: Elias Koutsoukos and Elias Angelopoulos

Lateral hypothalamic kindling induces manic-like behavior in rats: a novel animal model

The lateral hypothalamus integrates critical physiological functions such as the sleep-wake cycle, energy expenditure, and sexual behaviors. These functions are severely dysregulated during mania. In this stud...

Authors: Osama A Abulseoud, Ulas M Camsari, Christina L Ruby, Khalid Mohamed, Noha M Abdel Gawad, Aimen Kasasbeh, Mehmet Y Yüksel and Doo-Sup Choi

Are renal tumors associated with lithium treatment?

Authors: Ross J Baldessarini and Leonardo Tondo

Circadian biomarkers in patients with bipolar disorder: promising putative predictors of lithium response

Bipolar disorder (BD) is a common, severe mental disorder with a high recurrence rate. Lithium (Li) is the cornerstone of BD treatments to reduce recurrence, suicide, and mortality risks. However, only 30% of ...

Authors: Pierre Alexis Geoffroy, Bruno Etain, Sarah Sportiche and Frank Bellivier

Immunological and neurotrophic markers of risk status and illness development in high-risk youth: understanding the neurobiological underpinnings of bipolar disorder

Bipolar disorder is a highly heritable illness that onsets in adolescence and young adulthood. We examined gene expression (mRNA) and protein levels of candidate immune and neurotrophic markers in well-charact...

Authors: Anne Duffy, Julie Horrocks, Sarah Doucette, Charles Keown-Stoneman, Paul Grof, Ana Andreazza and L Trevor Young