Articles

Add-on treatment with N-acetylcysteine for bipolar depression: a 24-week randomized double-blind parallel group placebo-controlled multicentre trial (NACOS-study protocol)

Oxidative stress and inflammation may be involved in the development and progression of mood disorders, including bipolar disorder. Currently, there is a scarcity of useful treatment options for bipolar depres...

Authors: Pernille Kempel Ellegaard, Rasmus Wentzer Licht, Henrik Enghusen Poulsen, René Ernst Nielsen, Michael Berk, Olivia May Dean, Mohammadreza Mohebbi and Connie Thuroee Nielsen

Control charts for monitoring mood stability as a predictor of severe episodes in patients with bipolar disorder

Recurrent mood episodes and subsyndromal mood instability cause substantial disability in patients with bipolar disorder. Early identification of mood episodes enabling timely mood stabilization is an importan...

Authors: Maria D. L. A. Vazquez-Montes, Richard Stevens, Rafael Perera, Kate Saunders and John R. Geddes

Actigraphy as an objective intra-individual marker of activity patterns in acute-phase bipolar disorder: a case series

Actigraphy could be an objective alternative to clinical ratings of motor activity in bipolar disorder (BD), which is of importance now that increased activity and energy are added as cardinal symptoms of (hyp...

Authors: Karoline Krane-Gartiser, Andreas Asheim, Ole Bernt Fasmer, Gunnar Morken, Arne E. Vaaler and Jan Scott

Circulating antithyroid antibodies contribute to the decrease of glomerular filtration rate in lithium-treated patients: a longitudinal study

Concerns about the adverse effects of long-term treatment with lithium include reduced renal function. In the present study, we examined comorbidities which may be associated with chronic kidney disease in a c...

Authors: Alberto Bocchetta, Luca Ambrosiani, Gioia Baggiani, Claudia Pisanu, Caterina Chillotti, Raffaella Ardau, Fernanda Velluzzi, Doloretta Piras, Andrea Loviselli and Antonello Pani

The association between mood state and chronobiological characteristics in bipolar I disorder: a naturalistic, variable cluster analysis-based study

Multiple types of chronobiological disturbances have been reported in bipolar disorder, including characteristics associated with general activity levels, sleep, and rhythmicity. Previous studies have focused ...

Authors: Robert Gonzalez, Trisha Suppes, Jamie Zeitzer, Colleen McClung, Carol Tamminga, Mauricio Tohen, Angelica Forero, Alok Dwivedi and Andres Alvarado

Resilience concepts in psychiatry demonstrated with bipolar disorder

The term resilience describes stress–response patterns of subjects across scientific disciplines. In ecology, advances have been made to clearly distinguish resilience definitions based on underlying mechanist...

Authors: David G. Angeler, Craig R. Allen and Maj-Liz Persson

Smartphone-based objective monitoring in bipolar disorder: status and considerations

In 2001, the WHO stated that: “The use of mobile and wireless technologies to support the achievement of health objectives (mHealth) has the potential to transform the face of health service delivery across th...

Authors: Maria Faurholt-Jepsen, Michael Bauer and Lars Vedel Kessing

Association between CRP genetic diversity and bipolar disorder comorbid complications

Chronic low-grade inflammation is believed to contribute, at least in a subset of patients, to the development of bipolar disorder (BD). In this context, the most investigated biological marker is the acute ph...

Authors: Wahid Boukouaci, José Oliveira, Bruno Etain, Meriem Bennabi, Christina Mariaselvam, Nora Hamdani, Céline Manier, Djaouida Bengoufa, Frank Bellivier, Chantal Henry, Jean-Pierre Kahn, Dominique Charron, Rajagopal Krishnamoorthy, Marion Leboyer and Ryad Tamouza

Interrater reliability in bipolar disorder research: current practices and suggestions for enhancing best practices

Authors: June Gruber and Lauren M. Weinstock

Cognitive functioning following stabilisation from first episode mania

The purpose of this study was to examine cognitive functioning in people following first-episode mania relative to a demographically similar healthy control group.

Authors: Rothanthi Daglas, Kelly Allott, Murat Yücel, Lisa P. Henry, Craig A. Macneil, Melissa K. Hasty, Michael Berk and Sue M. Cotton

Mentalization deficit in bipolar patients during an acute depressive and manic episode: association with cognitive functions

A number of studies in bipolar patients have shown a deficit in mentalization (theory of mind), one of the main aspects of social cognition. The aim of current study was to assess both cognitive and affective ...

Authors: Anna Bodnar and Janusz K. Rybakowski

The clinical trajectory of emerging bipolar disorder among the high-risk offspring of bipolar parents: current understanding and future considerations

Relatively little is known about the onset of bipolar disorder, yet the early illness course is already associated with significant morbidity and mortality. Therefore, characterizing the bipolar illness trajec...

Authors: A. Duffy, C. Vandeleur, N. Heffer and M. Preisig

Anxiety, irritability, and agitation as indicators of bipolar mania with depressive symptoms: a post hoc analysis of two clinical trials

Symptoms of anxiety, irritability, and agitation (AIA) are prevalent among patients with bipolar I disorder (BD-I) mania with depressive symptoms, and could potentially be used to aid physicians in the identif...

Authors: Trisha Suppes, Jonas Eberhard, Ole Lemming, Allan H. Young and Roger S. McIntyre

Animal models for bipolar disorder: from bedside to the cage

Bipolar disorder is characterized by recurrent manic and depressive episodes. Patients suffering from this disorder experience dramatic mood swings with a wide variety of typical behavioral facets, affecting o...

Authors: Dominik K. E. Beyer and Nadja Freund

Does perfectionism in bipolar disorder pedigrees mediate associations between anxiety/stress and mood symptoms?

Bipolar disorder (BD) and the anxiety disorders are highly comorbid. The present study sought to examine perfectionism and goal attainment values as potential mechanisms of known associations between anxiety, ...

Authors: Justine Corry, Melissa Green, Gloria Roberts, Janice M. Fullerton, Peter R. Schofield and Philip B. Mitchell

The relationship between self-reported borderline personality features and prospective illness course in bipolar disorder

Although bipolar disorder (BD) and borderline personality disorder (BPD) share clinical characteristics and frequently co-occur, their interrelationship is controversial. Especially, the differentiation of rap...

Authors: Georg Riemann, Nadine Weisscher, Robert M. Post, Lori Altshuler, Susan McElroy, Marc A. Frye, Paul E. Keck Jr., Gabriele S. Leverich, Trisha Suppes, Heinz Grunze, Willem A. Nolen and Ralph W. Kupka

Erratum to: Prediction of vulnerability to bipolar disorder using multivariate neurocognitive patterns: a pilot study

In the original version of this article (Wu et al. 2017), published on 1 September 2017, the name of author ‘Bo Cao’ was wrongly displayed. In this Erratum the incorrect name and correct name are shown. The origi...

Authors: Mon-Ju Wu, Benson Mwangi, Ives Cavalcante Passos, Isabelle E. Bauer, Bo Cao, Thomas W. Frazier, Giovana B. Zunta-Soares and Jair C. Soares

Childhood maltreatment and the medical morbidity in bipolar disorder: a case–control study

Childhood maltreatment (abuse and neglect) can have long-term deleterious consequences, including increased risk for medical and psychiatric illnesses, such as bipolar disorder in adulthood. Emerging evidence ...

Authors: Georgina M. Hosang, Helen L. Fisher, Rudolf Uher, Sarah Cohen-Woods, Barbara Maughan, Peter McGuffin and Anne E. Farmer

Prediction of vulnerability to bipolar disorder using multivariate neurocognitive patterns: a pilot study

Bipolar disorder (BD) is a common disorder with high reoccurrence rate in general population. It is critical to have objective biomarkers to identify BD patients at an individual level. Neurocognitive signatur...

Authors: Mon-Ju Wu, Benson Mwangi, Ives Cavalcante Passos, Isabelle E. Bauer, Bo Cao, Thomas W. Frazier, Giovana B. Zunta-Soares and Jair C. Soares

Clinical correlates of age at onset distribution in bipolar disorder: a comparison between diagnostic subgroups

Admixture analysis of age at onset (AAO) has helped delineating the clinical profile of early onset (EO) bipolar disorder (BD). However, there is scarce evidence comparing the distributional properties of AAO ...

Authors: Mirko Manchia, Giuseppe Maina, Bernardo Carpiniello, Federica Pinna, Luca Steardo, Virginia D’Ambrosio, Virginio Salvi, Martin Alda, Alfonso Tortorella and Umberto Albert

Lifetime eating disorder comorbidity associated with delayed depressive recovery in bipolar disorder

Although eating disorders (EDs) are common in bipolar disorder (BD), little is known regarding their longitudinal consequences. We assessed prevalence, clinical correlates, and longitudinal depressive severity...

Authors: Danielle R. Balzafiore, Natalie L. Rasgon, Laura D. Yuen, Saloni Shah, Hyun Kim, Kathryn C. Goffin, Shefali Miller, Po W. Wang and Terence A. Ketter

Online ethics: where will the interface of mental health and the internet lead us?

While e-health initiatives are poised to revolutionize delivery and access to mental health care, conducting clinical research online involves specific contextual and ethical considerations. Face-to-face psych...

Authors: Victoria Cosgrove, Emma Gliddon, Lesley Berk, David Grimm, Sue Lauder, Seetal Dodd, Michael Berk and Trisha Suppes

Long-term lithium treatment in bipolar disorder: effects on glomerular filtration rate and other metabolic parameters

Concerns about potential adverse effects of long-term exposure to lithium as a mood-stabilizing treatment notably include altered renal function. However, the incidence of severe renal dysfunction; rate of dec...

Authors: Leonardo Tondo, Maria Abramowicz, Martin Alda, Michael Bauer, Alberto Bocchetta, Lorenza Bolzani, Cynthia V. Calkin, Caterina Chillotti, Diego Hidalgo-Mazzei, Mirko Manchia, Bruno Müller-Oerlinghausen, Andrea Murru, Giulio Perugi, Marco Pinna, Giuseppe Quaranta, Daniela Reginaldi…

Long-term response to mood stabilizer treatment and its clinical correlates in patients with bipolar disorders: a retrospective observational study

The efficacy and utility of long-term prophylactic treatment in patients with bipolar disorders (BDs) have not been fully explored. This study aims to estimate the long-term clinical response of patients with ...

Authors: Sung Woo Ahn, Ji Hyun Baek, So-Yung Yang, Yongkang Kim, Youngah Cho, Yujin Choi, Kounseok Lee, Taesung Park and Kyung Sue Hong

Cutaneous adverse reaction during lithium treatment: a case report and updated systematic review with meta-analysis

To present a new case of adverse cutaneous reaction during lithium treatment and to update the systematic review and meta-analysis of the incidence of this adverse reaction.

Authors: Martina Pinna, Mirko Manchia, Sergio Puddu, Giampaolo Minnai, Leonardo Tondo and Piergiorgio Salis

Efficacy and tolerability of lithium in treating acute mania in youth with bipolar disorder: protocol for a systematic review

Epidemiological, clinical, and high-risk studies have provided evidence that the peak period for onset of diagnosable episodes of mania and hypomania starts in mid-to-late adolescence. Moreover, clinically sig...

Authors: A. Duffy, S. Patten, S. Goodday, A. Weir, N. Heffer and A. Cipriani

Sexual distress and quality of life among women with bipolar disorder

Information on the association between bipolar disorder (BD), sexual satisfaction, sexual function, sexual distress and quality of life (QoL) is sparse. This study aims, in women with BD, to (i) investigate se...

Authors: Thea Sørensen, A. Giraldi and M. Vinberg

¹H-NMR, ¹H-NMR T₂-edited, and 2D-NMR in bipolar disorder metabolic profiling

The objective of this study was to identify molecular alterations in the human blood serum related to bipolar disorder, using nuclear magnetic resonance (NMR) spectroscopy and chemometrics.

Authors: Sumit Sethi, Mariana Pedrini, Lucas B. Rizzo, Maiara Zeni-Graiff, Caroline Dal Mas, Ana Cláudia Cassinelli, Mariane N. Noto, Elson Asevedo, Quirino Cordeiro, João G. M. Pontes, Antonio J. M. Brasil, Acioly Lacerda, Mirian A. F. Hayashi, Ronei Poppi, Ljubica Tasic and Elisa Brietzke

An observational study of 110 elderly lithium-treated patients followed up for 6 years with particular reference to renal function

Recent observational studies have focused on lithium treatment in the elderly, with particular reference to safety in terms of thyroid and renal functions. The purpose of this study was to compare the clinical...

Authors: Alberto Bocchetta, Francesca Cabras, Martina Pinna, Antonio Poddighe, Claudia Sardu, Raffaella Ardau, Caterina Chillotti and Maria Del Zompo

Response to letters by Baethge et al. and Martino et al.

Authors: Steven Marwaha and Andrew Thompson

Awaiting accurate scientific evidence: Progression or “profiles” in bipolar disorder?

This letter is written in response to a review recently published in the journal. The aim is to highlight a potential methodological limitation common to many studies comparing bipolar patients with few previo...

Authors: Diego J. Martino, Cecilia Samamé and Sergio A. Strejilevich

Methodological considerations regarding Joyce et al. 2016

Authors: Christopher Baethge, Leonardo Tondo and Ross J. Baldessarini

Impairment in emotion perception from body movements in individuals with bipolar I and bipolar II disorder is associated with functional capacity

Individuals with bipolar disorder present with moderate impairments in social cognition during the euthymic state. The impairment extends to theory of mind and to the perception of emotion in faces and voices,...

Authors: Anja Vaskinn, Trine Vik Lagerberg, Thomas D. Bjella, Carmen Simonsen, Ole A. Andreassen, Torill Ueland and Kjetil Sundet

Cognitive impairments and predominant polarity in bipolar disorder: a cross-sectional study

Bipolar disorder (BD) patients exhibit cognitive impairments during euthymic states. Studies suggest that manic episodes may be correlated to cognitive impairments. The present study investigated the relations...

Authors: Gabriel Okawa Belizario, Alexandre Duarte Gigante, Cristiana Castanho de Almeida Rocca and Beny Lafer

Lithium in the episode and suicide prophylaxis and in augmenting strategies in patients with unipolar depression

Depressive disorders are a leading cause of the global burden of disease and are associated with high recurrent often continuing morbidity and high excess mortality by suicide and cardiovascular disease. Whils...

Authors: Mohammed T. Abou-Saleh, Bruno Müller-Oerlinghausen and Alec J. Coppen

Self-poisoning suicide deaths in people with bipolar disorder: characterizing a subgroup and identifying treatment patterns

To characterize self-poisoning suicide deaths in BD compared to other suicide decedents.

Authors: Ayal Schaffer, Lauren M. Weinstock, Mark Sinyor, Catherine Reis, Benjamin I. Goldstein, Lakshmi N. Yatham and Anthony J. Levitt

Cognitive remediation for bipolar patients with objective cognitive impairment: a naturalistic study

Many bipolar patients (BP) are affected by cognitive impairments and reduced psychosocial function even after complete remission. In the present naturalistic study, we developed a tailored cognitive remediatio...

Authors: J. Veeh, J. Kopf, S. Kittel-Schneider, J. Deckert and A. Reif

Prodrome or risk syndrome: what’s in a name?

In the last decade, an increasing number of publications have examined the precursors of bipolar disorders (BD) and attempted to clarify the early origins and illness trajectory. This is a complex task as the...

Authors: Pierre Alexis Geoffroy and Jan Scott

Erratum to: Online information seeking by patients with bipolar disorder: results from an international multisite survey

Authors: Jörn Conell, Rita Bauer, Tasha Glenn, Martin Alda, Raffaella Ardau, Bernhard T. Baune, Michael Berk, Yuly Bersudsky, Amy Bilderbeck, Alberto Bocchetta, Letizia Bossini, Angela Marianne Paredes Castro, Eric Yat Wo Cheung, Caterina Chillotti, Sabine Choppin, Maria Del Zompo…

Poor quality of life and functioning in bipolar disorder

This study explores the association of demographic and clinical features with quality of life and functioning in individuals with bipolar disorder.

Authors: Louisa G. Sylvia, Rebecca E. Montana, Thilo Deckersbach, Michael E. Thase, Maurcio Tohen, Noreen Reilly-Harrington, Melvin G. McInnis, James H. Kocsis, Charles Bowden, Joseph Calabrese, Keming Gao, Terence Ketter, Richard C. Shelton, Susan L. McElroy, Edward S. Friedman, Dustin J. Rabideau…

Use of physical restraints among patients with bipolar disorder in Ethiopian Mental Specialized Hospital, outpatient department: cross-sectional study

Even though United Nation announced that all persons with a mental illness shall be treated with humanity and respect for the inherent dignity of the human being, up to now, the use of coercion (physical restr...

Authors: Habte Belete

Long-term use of lurasidone in patients with bipolar disorder: safety and effectiveness over 2 years of treatment

Bipolar disorder is a chronic illness with a 2-year recurrence rate of approximately 50% among individuals receiving treatment in the community. The aim of this 18-month, open-label, continuation study was to ...

Authors: Andrei Pikalov, Joyce Tsai, Yongcai Mao, Robert Silva, Josephine Cucchiaro and Antony Loebel

A pilot study to determine whether combinations of objectively measured activity parameters can be used to differentiate between mixed states, mania, and bipolar depression

Until recently, actigraphy studies in bipolar disorders focused on sleep rather than daytime activity in mania or depression, and have failed to analyse mixed episodes separately. Furthermore, even those studi...

Authors: Jan Scott, Arne E. Vaaler, Ole Bernt Fasmer, Gunnar Morken and Karoline Krane-Gartiser

Pilot study of a culturally adapted psychoeducation (CaPE) intervention for bipolar disorder in Pakistan

Despite the use of maintenance medication, recurrence rates in bipolar affective disorder (BPAD) are high. To date, there are no clinical trials that have investigated the use of psychological interventions i...

Authors: Muhammad Ishrat Husain, Imran B. Chaudhry, Raza R. Rahman, Munir M. Hamirani, Nasir Mehmood, Peter M. Haddad, John Hodsoll, Allan H. Young, Farooq Naeem and Nusrat Husain

Ethical perspectives on recommending digital technology for patients with mental illness

The digital revolution in medicine not only offers exciting new directions for the treatment of mental illness, but also presents challenges to patient privacy and security. Changes in medicine are part of the...

Authors: Michael Bauer, Tasha Glenn, Scott Monteith, Rita Bauer, Peter C. Whybrow and John Geddes

A systematic review of the frequency and severity of manic symptoms reported in studies that compare phenomenology across children, adolescents and adults with bipolar disorders

In the last two decades, there has been a significant increase in the diagnosis of Bipolar Disorder (BD) in children. The notion of prepubertal onsets of BD is not without controversy, with researchers debatin...

Authors: Faye Ryles, Thomas D. Meyer, Jaime Adan-Manes, Iain MacMillan and Jan Scott

American tertiary clinic-referred bipolar II disorder versus bipolar I disorder associated with hastened depressive recurrence

Bipolar disorder (BD) is a chronic, frequently comorbid condition characterized by high rates of mood episode recurrence and suicidality. Little is known about prospective longitudinal characterization of BD ...

Authors: Bernardo Dell’Osso, Saloni Shah, Dennis Do, Laura D. Yuen, Farnaz Hooshmand, Po W. Wang, Shefali Miller and Terence A. Ketter

The seroprevalence of antithyroid peroxidase antibodies in bipolar families and bipolar twins: results from two longitudinal studies

Previous studies of our group among bipolar offspring and bipolar twins showed significant higher prevalence’s and levels of antithyroid peroxidase antibodies (TPO-Abs) in offspring and co-twins (without a moo...

Authors: G. Snijders, L. de Witte, E. Mesman, S. Kemner, R. Vonk, R. Brouwer, W. A. Nolen, H. A. Drexhage and M. H. J. Hillegers

Lithium side effects and toxicity: prevalence and management strategies

Despite its virtually universal acceptance as the gold standard in treating bipolar disorder, prescription rates for lithium have been decreasing recently. Although this observation is multifactorial, one obvi...

Authors: Michael Gitlin

Serum concentrations of mood stabilizers are associated with memory, but not other cognitive domains in psychosis spectrum disorders; explorative analyses in a naturalistic setting

Mood stabilizers like lithium and anticonvulsants are used in bipolar and related psychotic disorders. There is a lack of knowledge of the relationship of these medications and cognition in the psychosis spect...

Authors: Nils Eiel Steen, Monica Aas, Carmen Simonsen, Ingrid Dieset, Martin Tesli, Mari Nerhus, Erlend Gardsjord, Ragni Mørch, Ingrid Agartz, Ingrid Melle, Anja Vaskinn, Olav Spigset and Ole A. Andreassen