Articles

Antidepressants in bipolar depression: an enduring controversy

The proper place and the optimal use of antidepressants in treating bipolar depression continues to be an area of great interest and greater controversy with passionate opinions more common than good studies. ...

Authors: Michael J. Gitlin

MOGENS SCHOU: 100th anniversary of his birth

Authors: Paul Grof and Bruno Müller-Oerlinghausen

Detecting significant genotype–phenotype association rules in bipolar disorder: market research meets complex genetics

Disentangling the etiology of common, complex diseases is a major challenge in genetic research. For bipolar disorder (BD), several genome-wide association studies (GWAS) have been performed. Similar to other ...

Authors: René Breuer, Manuel Mattheisen, Josef Frank, Bertram Krumm, Jens Treutlein, Layla Kassem, Jana Strohmaier, Stefan Herms, Thomas W. Mühleisen, Franziska Degenhardt, Sven Cichon, Markus M. Nöthen, George Karypis, John Kelsoe, Tiffany Greenwood, Caroline Nievergelt…

The challenges of living with bipolar disorder: a qualitative study of the implications for health care and research

In mental health care, clinical practice is often based on the best available research evidence. However, research findings are difficult to apply to clinical practice, resulting in an implementation gap. To b...

Authors: Eva F. Maassen, Barbara J. Regeer, Eline J. Regeer, Joske F. G. Bunders and Ralph W. Kupka

A nationwide study on concordance with multimodal treatment guidelines in bipolar disorder

Most previous studies on concordance with treatment guidelines for bipolar disorder focused on pharmacotherapy. Few studies have included other treatment modalities.

Authors: Joannes W. Renes, Eline J. Regeer, Adriaan W. Hoogendoorn, Willem A. Nolen and Ralph W. Kupka

Shared decision making in pharmacotherapy decisions, perceived by patients with bipolar disorder

Shared decision making has been promoted as standard care, but there has been debate on the possible types. On the one hand, there is a more ‘instrumental’/objective approach focused on the exchange of informa...

Authors: Doris Verwijmeren and Koen P. Grootens

Clinical characteristics of patients with bipolar disorder and premorbid traumatic brain injury: a cross-sectional study

About one in ten diagnosed with bipolar disorder (BD) has experienced a premorbid traumatic brain injury (TBI), while not fulfilling the criteria of bipolar and related disorder due to another medical conditio...

Authors: Ole Kristian Drange, Arne Einar Vaaler, Gunnar Morken, Ole Andreas Andreassen, Ulrik Fredrik Malt and Per Ivar Finseth

Internet use by older adults with bipolar disorder: international survey results

The world population is aging and the number of older adults with bipolar disorder is increasing. Digital technologies are viewed as a framework to improve care of older adults with bipolar disorder. This anal...

Authors: Rita Bauer, Tasha Glenn, Sergio Strejilevich, Jörn Conell, Martin Alda, Raffaella Ardau, Bernhard T. Baune, Michael Berk, Yuly Bersudsky, Amy Bilderbeck, Alberto Bocchetta, Angela M. Paredes Castro, Eric Y. W. Cheung, Caterina Chillotti, Sabine Choppin, Alessandro Cuomo…

Aggression among 216 patients with a first-psychotic episode of bipolar I disorder

Aggression by patients with bipolar I disorder (BD-I) is not uncommon. Identifying potential risk factors early in the illness-course should inform clinical management and reduce risk.

Authors: Hari-Mandir K. Khalsa, Ross J. Baldessarini, Mauricio Tohen and Paola Salvatore

Thyroid and renal tumors in patients treated with long-term lithium: case series from a lithium clinic, review of the literature and international pharmacovigilance reports

Cancer had never been considered as a relevant problem in patients treated with lithium until 2015, when a document published by the European Medicine Agency concluded that long-term use of lithium might induc...

Authors: Luca Ambrosiani, Claudia Pisanu, Arianna Deidda, Caterina Chillotti, Maria Erminia Stochino and Alberto Bocchetta

Regional cortical thinning in young adults with schizophrenia but not psychotic or non-psychotic bipolar I disorder

Schizophrenia shares some genetic risk and clinical symptoms with bipolar disorder. Clinical heterogeneity across subjects is thought to contribute to variable structural imaging findings across studies. The c...

Authors: Douglass Godwin, Kathryn I. Alpert, Lei Wang and Daniel Mamah

Lack of emotional gaze preferences using eye-tracking in remitted bipolar I disorder

Bipolar disorder is associated with heightened and persistent positive emotion (Gruber in Curr Dir Psychol Sci 20:217–221, 2011; Johnson in Clin Psychol Rev 25:241–262, 2005). Yet little is known about informatio...

Authors: John R. Purcell, Monika Lohani, Christie Musket, Aleena C. Hay, Derek M. Isaacowitz and June Gruber

Aripiprazole once-monthly as maintenance treatment for bipolar I disorder: a 52-week, multicenter, open-label study

The long-acting injectable antipsychotic aripiprazole once-monthly 400 mg (AOM 400) was recently approved for maintenance treatment of bipolar I disorder (BP-I). The purpose of this study was to evaluate the s...

Authors: Joseph R. Calabrese, Na Jin, Brian Johnson, Pedro Such, Ross A. Baker, Jessica Madera, Peter Hertel, Jocelyn Ottinger, Joan Amatniek and Hiroaki Kawasaki

The perspectives of patients with lithium-induced end-stage renal disease

Lithium is the treatment of choice for patients suffering from bipolar disorder (BD) but prolonged use induces renal dysfunction in at least 20% of patient. Intensive monitoring of kidney functioning helps to ...

Authors: Angèle P. M. Kerckhoffs, Erwin G. T. M. Hartong and Koen P. Grootens

Behavioural biomarkers and mobile mental health: a new paradigm

Over recent decades, the field of psychiatry has allocated a vast amount of resources and efforts to make available more accurate and objective methods to diagnose, assess and monitor treatment outcomes in psy...

Authors: Diego Hidalgo-Mazzei, Allan H. Young, Eduard Vieta and Francesc Colom

Regularity of self-reported daily dosage of mood stabilizers and antipsychotics in patients with bipolar disorder

Polypharmacy is often prescribed for bipolar disorder, yet medication non-adherence remains a serious problem. This study investigated the regularity in the daily dosage taken of mood stabilizers and second ge...

Authors: Maximilian Pilhatsch, Tasha Glenn, Natalie Rasgon, Martin Alda, Kemal Sagduyu, Paul Grof, Rodrigo Munoz, Wendy Marsh, Scott Monteith, Emanuel Severus, Rita Bauer, Philipp Ritter, Peter C. Whybrow and Michael Bauer

Monitoring of patients treated with lithium for bipolar disorder: an international survey

Adequate monitoring of patients using lithium is needed for optimal dosing and for early identification of patients with (potential) ADEs. The objective was to internationally assess how health care profession...

Authors: M. Nederlof, E. R. Heerdink, A. C. G. Egberts, I. Wilting, L. J. Stoker, R. Hoekstra and R. W. Kupka

Add-on treatment with N-acetylcysteine for bipolar depression: a 24-week randomized double-blind parallel group placebo-controlled multicentre trial (NACOS-study protocol)

Oxidative stress and inflammation may be involved in the development and progression of mood disorders, including bipolar disorder. Currently, there is a scarcity of useful treatment options for bipolar depres...

Authors: Pernille Kempel Ellegaard, Rasmus Wentzer Licht, Henrik Enghusen Poulsen, René Ernst Nielsen, Michael Berk, Olivia May Dean, Mohammadreza Mohebbi and Connie Thuroee Nielsen

Control charts for monitoring mood stability as a predictor of severe episodes in patients with bipolar disorder

Recurrent mood episodes and subsyndromal mood instability cause substantial disability in patients with bipolar disorder. Early identification of mood episodes enabling timely mood stabilization is an importan...

Authors: Maria D. L. A. Vazquez-Montes, Richard Stevens, Rafael Perera, Kate Saunders and John R. Geddes

Actigraphy as an objective intra-individual marker of activity patterns in acute-phase bipolar disorder: a case series

Actigraphy could be an objective alternative to clinical ratings of motor activity in bipolar disorder (BD), which is of importance now that increased activity and energy are added as cardinal symptoms of (hyp...

Authors: Karoline Krane-Gartiser, Andreas Asheim, Ole Bernt Fasmer, Gunnar Morken, Arne E. Vaaler and Jan Scott

Circulating antithyroid antibodies contribute to the decrease of glomerular filtration rate in lithium-treated patients: a longitudinal study

Concerns about the adverse effects of long-term treatment with lithium include reduced renal function. In the present study, we examined comorbidities which may be associated with chronic kidney disease in a c...

Authors: Alberto Bocchetta, Luca Ambrosiani, Gioia Baggiani, Claudia Pisanu, Caterina Chillotti, Raffaella Ardau, Fernanda Velluzzi, Doloretta Piras, Andrea Loviselli and Antonello Pani

The association between mood state and chronobiological characteristics in bipolar I disorder: a naturalistic, variable cluster analysis-based study

Multiple types of chronobiological disturbances have been reported in bipolar disorder, including characteristics associated with general activity levels, sleep, and rhythmicity. Previous studies have focused ...

Authors: Robert Gonzalez, Trisha Suppes, Jamie Zeitzer, Colleen McClung, Carol Tamminga, Mauricio Tohen, Angelica Forero, Alok Dwivedi and Andres Alvarado

Resilience concepts in psychiatry demonstrated with bipolar disorder

The term resilience describes stress–response patterns of subjects across scientific disciplines. In ecology, advances have been made to clearly distinguish resilience definitions based on underlying mechanist...

Authors: David G. Angeler, Craig R. Allen and Maj-Liz Persson

Smartphone-based objective monitoring in bipolar disorder: status and considerations

In 2001, the WHO stated that: “The use of mobile and wireless technologies to support the achievement of health objectives (mHealth) has the potential to transform the face of health service delivery across th...

Authors: Maria Faurholt-Jepsen, Michael Bauer and Lars Vedel Kessing

Association between CRP genetic diversity and bipolar disorder comorbid complications

Chronic low-grade inflammation is believed to contribute, at least in a subset of patients, to the development of bipolar disorder (BD). In this context, the most investigated biological marker is the acute ph...

Authors: Wahid Boukouaci, José Oliveira, Bruno Etain, Meriem Bennabi, Christina Mariaselvam, Nora Hamdani, Céline Manier, Djaouida Bengoufa, Frank Bellivier, Chantal Henry, Jean-Pierre Kahn, Dominique Charron, Rajagopal Krishnamoorthy, Marion Leboyer and Ryad Tamouza

Interrater reliability in bipolar disorder research: current practices and suggestions for enhancing best practices

Authors: June Gruber and Lauren M. Weinstock

Cognitive functioning following stabilisation from first episode mania

The purpose of this study was to examine cognitive functioning in people following first-episode mania relative to a demographically similar healthy control group.

Authors: Rothanthi Daglas, Kelly Allott, Murat Yücel, Lisa P. Henry, Craig A. Macneil, Melissa K. Hasty, Michael Berk and Sue M. Cotton

Mentalization deficit in bipolar patients during an acute depressive and manic episode: association with cognitive functions

A number of studies in bipolar patients have shown a deficit in mentalization (theory of mind), one of the main aspects of social cognition. The aim of current study was to assess both cognitive and affective ...

Authors: Anna Bodnar and Janusz K. Rybakowski

The clinical trajectory of emerging bipolar disorder among the high-risk offspring of bipolar parents: current understanding and future considerations

Relatively little is known about the onset of bipolar disorder, yet the early illness course is already associated with significant morbidity and mortality. Therefore, characterizing the bipolar illness trajec...

Authors: A. Duffy, C. Vandeleur, N. Heffer and M. Preisig

Anxiety, irritability, and agitation as indicators of bipolar mania with depressive symptoms: a post hoc analysis of two clinical trials

Symptoms of anxiety, irritability, and agitation (AIA) are prevalent among patients with bipolar I disorder (BD-I) mania with depressive symptoms, and could potentially be used to aid physicians in the identif...

Authors: Trisha Suppes, Jonas Eberhard, Ole Lemming, Allan H. Young and Roger S. McIntyre

Animal models for bipolar disorder: from bedside to the cage

Bipolar disorder is characterized by recurrent manic and depressive episodes. Patients suffering from this disorder experience dramatic mood swings with a wide variety of typical behavioral facets, affecting o...

Authors: Dominik K. E. Beyer and Nadja Freund

Does perfectionism in bipolar disorder pedigrees mediate associations between anxiety/stress and mood symptoms?

Bipolar disorder (BD) and the anxiety disorders are highly comorbid. The present study sought to examine perfectionism and goal attainment values as potential mechanisms of known associations between anxiety, ...

Authors: Justine Corry, Melissa Green, Gloria Roberts, Janice M. Fullerton, Peter R. Schofield and Philip B. Mitchell

The relationship between self-reported borderline personality features and prospective illness course in bipolar disorder

Although bipolar disorder (BD) and borderline personality disorder (BPD) share clinical characteristics and frequently co-occur, their interrelationship is controversial. Especially, the differentiation of rap...

Authors: Georg Riemann, Nadine Weisscher, Robert M. Post, Lori Altshuler, Susan McElroy, Marc A. Frye, Paul E. Keck Jr., Gabriele S. Leverich, Trisha Suppes, Heinz Grunze, Willem A. Nolen and Ralph W. Kupka

Erratum to: Prediction of vulnerability to bipolar disorder using multivariate neurocognitive patterns: a pilot study

In the original version of this article (Wu et al. 2017), published on 1 September 2017, the name of author ‘Bo Cao’ was wrongly displayed. In this Erratum the incorrect name and correct name are shown. The origi...

Authors: Mon-Ju Wu, Benson Mwangi, Ives Cavalcante Passos, Isabelle E. Bauer, Bo Cao, Thomas W. Frazier, Giovana B. Zunta-Soares and Jair C. Soares

Childhood maltreatment and the medical morbidity in bipolar disorder: a case–control study

Childhood maltreatment (abuse and neglect) can have long-term deleterious consequences, including increased risk for medical and psychiatric illnesses, such as bipolar disorder in adulthood. Emerging evidence ...

Authors: Georgina M. Hosang, Helen L. Fisher, Rudolf Uher, Sarah Cohen-Woods, Barbara Maughan, Peter McGuffin and Anne E. Farmer

Prediction of vulnerability to bipolar disorder using multivariate neurocognitive patterns: a pilot study

Bipolar disorder (BD) is a common disorder with high reoccurrence rate in general population. It is critical to have objective biomarkers to identify BD patients at an individual level. Neurocognitive signatur...

Authors: Mon-Ju Wu, Benson Mwangi, Ives Cavalcante Passos, Isabelle E. Bauer, Bo Cao, Thomas W. Frazier, Giovana B. Zunta-Soares and Jair C. Soares

Clinical correlates of age at onset distribution in bipolar disorder: a comparison between diagnostic subgroups

Admixture analysis of age at onset (AAO) has helped delineating the clinical profile of early onset (EO) bipolar disorder (BD). However, there is scarce evidence comparing the distributional properties of AAO ...

Authors: Mirko Manchia, Giuseppe Maina, Bernardo Carpiniello, Federica Pinna, Luca Steardo, Virginia D’Ambrosio, Virginio Salvi, Martin Alda, Alfonso Tortorella and Umberto Albert

Lifetime eating disorder comorbidity associated with delayed depressive recovery in bipolar disorder

Although eating disorders (EDs) are common in bipolar disorder (BD), little is known regarding their longitudinal consequences. We assessed prevalence, clinical correlates, and longitudinal depressive severity...

Authors: Danielle R. Balzafiore, Natalie L. Rasgon, Laura D. Yuen, Saloni Shah, Hyun Kim, Kathryn C. Goffin, Shefali Miller, Po W. Wang and Terence A. Ketter

Online ethics: where will the interface of mental health and the internet lead us?

While e-health initiatives are poised to revolutionize delivery and access to mental health care, conducting clinical research online involves specific contextual and ethical considerations. Face-to-face psych...

Authors: Victoria Cosgrove, Emma Gliddon, Lesley Berk, David Grimm, Sue Lauder, Seetal Dodd, Michael Berk and Trisha Suppes

Long-term lithium treatment in bipolar disorder: effects on glomerular filtration rate and other metabolic parameters

Concerns about potential adverse effects of long-term exposure to lithium as a mood-stabilizing treatment notably include altered renal function. However, the incidence of severe renal dysfunction; rate of dec...

Authors: Leonardo Tondo, Maria Abramowicz, Martin Alda, Michael Bauer, Alberto Bocchetta, Lorenza Bolzani, Cynthia V. Calkin, Caterina Chillotti, Diego Hidalgo-Mazzei, Mirko Manchia, Bruno Müller-Oerlinghausen, Andrea Murru, Giulio Perugi, Marco Pinna, Giuseppe Quaranta, Daniela Reginaldi…

Long-term response to mood stabilizer treatment and its clinical correlates in patients with bipolar disorders: a retrospective observational study

The efficacy and utility of long-term prophylactic treatment in patients with bipolar disorders (BDs) have not been fully explored. This study aims to estimate the long-term clinical response of patients with ...

Authors: Sung Woo Ahn, Ji Hyun Baek, So-Yung Yang, Yongkang Kim, Youngah Cho, Yujin Choi, Kounseok Lee, Taesung Park and Kyung Sue Hong

Cutaneous adverse reaction during lithium treatment: a case report and updated systematic review with meta-analysis

To present a new case of adverse cutaneous reaction during lithium treatment and to update the systematic review and meta-analysis of the incidence of this adverse reaction.

Authors: Martina Pinna, Mirko Manchia, Sergio Puddu, Giampaolo Minnai, Leonardo Tondo and Piergiorgio Salis

Efficacy and tolerability of lithium in treating acute mania in youth with bipolar disorder: protocol for a systematic review

Epidemiological, clinical, and high-risk studies have provided evidence that the peak period for onset of diagnosable episodes of mania and hypomania starts in mid-to-late adolescence. Moreover, clinically sig...

Authors: A. Duffy, S. Patten, S. Goodday, A. Weir, N. Heffer and A. Cipriani

Sexual distress and quality of life among women with bipolar disorder

Information on the association between bipolar disorder (BD), sexual satisfaction, sexual function, sexual distress and quality of life (QoL) is sparse. This study aims, in women with BD, to (i) investigate se...

Authors: Thea Sørensen, A. Giraldi and M. Vinberg

¹H-NMR, ¹H-NMR T₂-edited, and 2D-NMR in bipolar disorder metabolic profiling

The objective of this study was to identify molecular alterations in the human blood serum related to bipolar disorder, using nuclear magnetic resonance (NMR) spectroscopy and chemometrics.

Authors: Sumit Sethi, Mariana Pedrini, Lucas B. Rizzo, Maiara Zeni-Graiff, Caroline Dal Mas, Ana Cláudia Cassinelli, Mariane N. Noto, Elson Asevedo, Quirino Cordeiro, João G. M. Pontes, Antonio J. M. Brasil, Acioly Lacerda, Mirian A. F. Hayashi, Ronei Poppi, Ljubica Tasic and Elisa Brietzke

An observational study of 110 elderly lithium-treated patients followed up for 6 years with particular reference to renal function

Recent observational studies have focused on lithium treatment in the elderly, with particular reference to safety in terms of thyroid and renal functions. The purpose of this study was to compare the clinical...

Authors: Alberto Bocchetta, Francesca Cabras, Martina Pinna, Antonio Poddighe, Claudia Sardu, Raffaella Ardau, Caterina Chillotti and Maria Del Zompo

Response to letters by Baethge et al. and Martino et al.

Authors: Steven Marwaha and Andrew Thompson

Awaiting accurate scientific evidence: Progression or “profiles” in bipolar disorder?

This letter is written in response to a review recently published in the journal. The aim is to highlight a potential methodological limitation common to many studies comparing bipolar patients with few previo...

Authors: Diego J. Martino, Cecilia Samamé and Sergio A. Strejilevich

Methodological considerations regarding Joyce et al. 2016

Authors: Christopher Baethge, Leonardo Tondo and Ross J. Baldessarini

Impairment in emotion perception from body movements in individuals with bipolar I and bipolar II disorder is associated with functional capacity

Individuals with bipolar disorder present with moderate impairments in social cognition during the euthymic state. The impairment extends to theory of mind and to the perception of emotion in faces and voices,...

Authors: Anja Vaskinn, Trine Vik Lagerberg, Thomas D. Bjella, Carmen Simonsen, Ole A. Andreassen, Torill Ueland and Kjetil Sundet