Articles

Short group psychoeducation followed by daily electronic self-monitoring in the long-term treatment of bipolar disorders: a multicenter, rater-blind, randomized controlled trial

Despite various pharmacological and psychological treatment interventions, bipolar disorders rank among the leading causes of global disease burden. Group psychoeducation has been demonstrated an effective add...

Authors: Johannes Petzold, René Mayer-Pelinski, Maximilian Pilhatsch, Susan Luthe, Thomas Barth, Michael Bauer and Emanuel Severus

Investigating the association between anxiety symptoms and mood disorder in high-risk offspring of bipolar parents: a comparison of Joint and Cox models

Anxiety is associated with mood disorders including bipolar disorder. Two statistical modelling frameworks were compared to investigate the longitudinal relationship between repeatedly measured anxiety symptom...

Authors: Ruoxi Dong, George Stefan, Julie Horrocks, Sarah M. Goodday and Anne Duffy

Treatment of bipolar depression with supraphysiologic doses of levothyroxine: a randomized, placebo-controlled study of comorbid anxiety symptoms

Symptoms of anxiety co-occur in a variety of disorders including in depressive episodes of bipolar disorder and in patients with thyrotoxicosis. Treatment of refractory bipolar disorder with supraphysiologic d...

Authors: Maximilian Pilhatsch, Thomas J Stamm, Petra Stahl, Ute Lewitzka, Anne Berghöfer, Cathrin Sauer, Michael Gitlin, Mark A. Frye, Peter C. Whybrow and Michael Bauer

Prospective cohort study of early biosignatures of response to lithium in bipolar-I-disorders: overview of the H2020-funded R-LiNK initiative

Lithium is recommended as a first line treatment for bipolar disorders. However, only 30% of patients show an optimal outcome and variability in lithium response and tolerability is poorly understood. It remai...

Authors: Jan Scott, Diego Hidalgo-Mazzei, Rebecca Strawbridge, Allan Young, Matthieu Resche-Rigon, Bruno Etain, Ole A. Andreassen, Michael Bauer, Djamila Bennabi, Andrew M. Blamire, Fawzi Boumezbeur, Paolo Brambilla, Nadia Cattane, Annamaria Cattaneo, Marie Chupin, Klara Coello…

Trajectories of adherence to mood stabilizers in patients with bipolar disorder

Nonadherence with mood stabilizers is a major problem that negatively impacts the course of bipolar disorder. Medication adherence is a complex individual behavior, and adherence rates often change over time. ...

Authors: M. Bauer, T. Glenn, M. Alda, R. Bauer, P. Grof, W. Marsh, S. Monteith, R. Munoz, N. Rasgon, K. Sagduyu and P. C. Whybrow

Exploring the clinical outcome of Mindfulness-Based Cognitive Therapy for bipolar and unipolar depressive patients in routine clinical practice: a pilot study

Mindfulness Based Cognitive Therapy (MBCT) has been adopted as an evidence-based treatment for unipolar depressive disorder (UDD). Although MBCT has not been included in the treatment guidelines for bipolar di...

Authors: I. Hanssen, M. I. van Dord, F. R. Compen, D. E. M. Geurts, M. P. J. Schellekens and A. E. M. Speckens

Epigenetic markers in inflammation-related genes associated with mood disorder: a cross-sectional and longitudinal study in high-risk offspring of bipolar parents

Bipolar disorder is highly heritable and typically onsets in late adolescence or early adulthood. Evidence suggests that immune activation may be a mediating pathway between genetic predisposition and onset of...

Authors: Anne Duffy, Sarah M. Goodday, Charles Keown-Stoneman, Martina Scotti, Malosree Maitra, Corina Nagy, Julie Horrocks and Gustavo Turecki

Clinical use of lithium salts: guide for users and prescribers

Lithium has been used clinically for 70 years, mainly to treat bipolar disorder. Competing treatments and exaggerated impressions about complexity and risks of lithium treatment have led to its declining use i...

Authors: Leonardo Tondo, Martin Alda, Michael Bauer, Veerle Bergink, Paul Grof, Tomas Hajek, Ute Lewitka, Rasmus W. Licht, Mirko Manchia, Bruno Müller-Oerlinghausen, René E. Nielsen, Marylou Selo, Christian Simhandl and Ross J. Baldessarini

Alec J. Coppen—A pioneering psychiatrist who discovered the pivotal role of serotonin in the pathogenesis of depression as well as the antisuicidal effect of lithium

Authors: Bruno Müller-Oerlinghausen and Mohammed T. Abou-Saleh

Neuropsychological profiles of adult bipolar disorder patients with and without comorbid attention-deficit hyperactivity disorder

Comorbid attention-deficit/hyperactivity disorder (ADHD) is common in bipolar disorder and associated with worse outcomes. Cognitive testing might be a tool to identify this group. Here we compare the neuropsy...

Authors: Sara Salarvan, Timea Sparding, Caitlin Clements, Eleonore Rydén and Mikael Landén

Attenuated inflammatory response of monocyte-derived macrophage from patients with BD: a preliminary report

Innate immune system dysfunction has been recognized as an important element in the pathophysiology of bipolar disorder (BD). We aimed to investigate whether there are differences in the response of macrophage...

Authors: Bruna M. Ascoli, Mariana M. Parisi, Giovana Bristot, Bárbara Antqueviezc, Luiza P. Géa, Rafael Colombo, Flávio Kapczinski, Fátima Theresinha Costa Rodrigues Guma, Elisa Brietzke, Florencia M. Barbé-Tuana and Adriane R. Rosa

Why are somatic diseases in bipolar disorder insufficiently treated?

Somatic diseases, including cardiovascular, respiratory, and cancer diseases, are the main contributors to a shortened life expectancy of 10–20 years in patients with bipolar disorder as compared to the genera...

Authors: René Ernst Nielsen, Pirathiv Kugathasan, Sune Straszek, Svend Eggert Jensen and Rasmus W. Licht

Electroconvulsive therapy electrode placement for bipolar state-related targeted engagement

Electroconvulsive therapy (ECT) is an effective treatment for all bipolar states. However, ECT remains underutilized, likely stemming from stigma and the risk of neurocognitive impairment. Neuroimaging researc...

Authors: Christopher C. Abbott, Jeremy Miller, Megan Lloyd and Mauricio Tohen

Intra-individual variability in animal models of bipolar disorder

Authors: Emily R. Hawken, Elisa Brietzke and Claudio N. Soares

Metabolic profile in patients with newly diagnosed bipolar disorder and their unaffected first-degree relatives

The prevalence of metabolic syndrome and insulin resistance is twice as high in patients with bipolar disorder compared with the general population, and possibly associated with a disabling illness trajectory ...

Authors: Klara Coello, Maj Vinberg, Filip K. Knop, Bente K. Pedersen, Roger S. McIntyre, Lars V. Kessing and Klaus Munkholm

Controversies in bipolar disorder; role of second-generation antipsychotic for maintenance therapy

In this narrative review, we discuss use of second-generation antipsychotics (SGAs) in maintenance treatment of bipolar disorder. We compare their use to historically more established treatments (particularly ...

Authors: Sameer Jauhar and Allan H. Young

“What if I get ill?” Perinatal concerns and preparations in primi- and multiparous women with bipolar disorder

Women with bipolar disorder have a high risk of illness relapse postpartum, including psychosis. The aim of the study was to explore how perinatal women with bipolar disorder relate to the risk. What are their...

Authors: Teija M. S. Anke, Kari Slinning and Dag Vegard Skjelstad

Mortality rate trends in patients diagnosed with schizophrenia or bipolar disorder: a nationwide study with 20 years of follow-up

Patients with severe mental illness (SMI) have a reduced life expectancy of one to two decades as compared to the general population, with most years of life lost due to somatic diseases. Most previous studies...

Authors: Line Hosbond Lomholt, Diana Vincens Andersen, Christina Sejrsgaard-Jacobsen, Cagla Margit Øzdemir, Claus Graff, Ole Schjerning, Svend Eggert Jensen, Sune Puggard Vogt Straszek, Rasmus W. Licht, Simon Grøntved and René Ernst Nielsen

Genetic and environmental influences on circulating NK and T cells and their relation to bipolar disorder

In previous studies we found mild deficiencies of circulating T cells in patients with bipolar disorder (BD) and children at risk for BD, correlating to a higher inflammatory state. The genetic and environment...

Authors: G. Snijders, R. Brouwer, S. Kemner, F. Bootsman, H. A. Drexhage and M. H. J. Hillegers

Differences in mood instability in patients with bipolar disorder type I and II: a smartphone-based study

Mood instability in bipolar disorder is associated with a risk of relapse. This study investigated differences in mood instability between patients with bipolar disorder type I and type II, which previously ha...

Authors: Maria Faurholt-Jepsen, Mads Frost, Jonas Busk, Ellen Margrethe Christensen, Jakob E. Bardram, Maj Vinberg and Lars Vedel Kessing

Rumination related activity in brain networks mediating attentional switching in euthymic bipolar patients

Mood disorder patients have a tendency to be more internally oriented, with difficulties in switching attentional focus, which might result in the generation of negative thoughts, such as rumination. The prese...

Authors: Kallia Apazoglou, Anne-Lise Küng, Paolo Cordera, Jean-Michel Aubry, Alexandre Dayer, Patrik Vuilleumier and Camille Piguet

Show yourself, a short film to show professionals at an admission ward your ‘euthymic being’ during an admission for mania

The progress and recovery of a patient with mania during hospitalization is differently seen by professionals working at an admission ward and by relatives of the patient. Professionals often indicate that the...

Authors: P. J. J. Goossens, T. H. Daggenvoorde, H. G. Groot Lipman, S. Verhaeghe and A. W. M. M. Stevens

Smartphone-based self-monitoring in bipolar disorder: evaluation of usability and feasibility of two systems

The aims of the present multicenter pilot study were to examine the feasibility and usability of two different smartphone-based monitoring systems (the Pulso system and the Trilogis-Monsenso system) from two I...

Authors: Maria Faurholt-Jepsen, Emanuale Torri, Jesús Cobo, Daryoush Yazdanyar, Diego Palao, Narcis Cardoner, Olaf Andreatta, Oscar Mayora and Lars Vedel Kessing

Lithium during pregnancy and after delivery: a review

Lithium is an effective treatment in pregnancy and postpartum for the prevention of relapse in bipolar disorder. However, lithium has also been associated with risks during pregnancy for both the mother and th...

Authors: Eline M. P. Poels, Hilmar H. Bijma, Megan Galbally and Veerle Bergink

Antidepressants in bipolar depression: an enduring controversy

The proper place and the optimal use of antidepressants in treating bipolar depression continues to be an area of great interest and greater controversy with passionate opinions more common than good studies. ...

Authors: Michael J. Gitlin

MOGENS SCHOU: 100th anniversary of his birth

Authors: Paul Grof and Bruno Müller-Oerlinghausen

Detecting significant genotype–phenotype association rules in bipolar disorder: market research meets complex genetics

Disentangling the etiology of common, complex diseases is a major challenge in genetic research. For bipolar disorder (BD), several genome-wide association studies (GWAS) have been performed. Similar to other ...

Authors: René Breuer, Manuel Mattheisen, Josef Frank, Bertram Krumm, Jens Treutlein, Layla Kassem, Jana Strohmaier, Stefan Herms, Thomas W. Mühleisen, Franziska Degenhardt, Sven Cichon, Markus M. Nöthen, George Karypis, John Kelsoe, Tiffany Greenwood, Caroline Nievergelt…

The challenges of living with bipolar disorder: a qualitative study of the implications for health care and research

In mental health care, clinical practice is often based on the best available research evidence. However, research findings are difficult to apply to clinical practice, resulting in an implementation gap. To b...

Authors: Eva F. Maassen, Barbara J. Regeer, Eline J. Regeer, Joske F. G. Bunders and Ralph W. Kupka

A nationwide study on concordance with multimodal treatment guidelines in bipolar disorder

Most previous studies on concordance with treatment guidelines for bipolar disorder focused on pharmacotherapy. Few studies have included other treatment modalities.

Authors: Joannes W. Renes, Eline J. Regeer, Adriaan W. Hoogendoorn, Willem A. Nolen and Ralph W. Kupka

Shared decision making in pharmacotherapy decisions, perceived by patients with bipolar disorder

Shared decision making has been promoted as standard care, but there has been debate on the possible types. On the one hand, there is a more ‘instrumental’/objective approach focused on the exchange of informa...

Authors: Doris Verwijmeren and Koen P. Grootens

Clinical characteristics of patients with bipolar disorder and premorbid traumatic brain injury: a cross-sectional study

About one in ten diagnosed with bipolar disorder (BD) has experienced a premorbid traumatic brain injury (TBI), while not fulfilling the criteria of bipolar and related disorder due to another medical conditio...

Authors: Ole Kristian Drange, Arne Einar Vaaler, Gunnar Morken, Ole Andreas Andreassen, Ulrik Fredrik Malt and Per Ivar Finseth

Internet use by older adults with bipolar disorder: international survey results

The world population is aging and the number of older adults with bipolar disorder is increasing. Digital technologies are viewed as a framework to improve care of older adults with bipolar disorder. This anal...

Authors: Rita Bauer, Tasha Glenn, Sergio Strejilevich, Jörn Conell, Martin Alda, Raffaella Ardau, Bernhard T. Baune, Michael Berk, Yuly Bersudsky, Amy Bilderbeck, Alberto Bocchetta, Angela M. Paredes Castro, Eric Y. W. Cheung, Caterina Chillotti, Sabine Choppin, Alessandro Cuomo…

Aggression among 216 patients with a first-psychotic episode of bipolar I disorder

Aggression by patients with bipolar I disorder (BD-I) is not uncommon. Identifying potential risk factors early in the illness-course should inform clinical management and reduce risk.

Authors: Hari-Mandir K. Khalsa, Ross J. Baldessarini, Mauricio Tohen and Paola Salvatore

Thyroid and renal tumors in patients treated with long-term lithium: case series from a lithium clinic, review of the literature and international pharmacovigilance reports

Cancer had never been considered as a relevant problem in patients treated with lithium until 2015, when a document published by the European Medicine Agency concluded that long-term use of lithium might induc...

Authors: Luca Ambrosiani, Claudia Pisanu, Arianna Deidda, Caterina Chillotti, Maria Erminia Stochino and Alberto Bocchetta

Regional cortical thinning in young adults with schizophrenia but not psychotic or non-psychotic bipolar I disorder

Schizophrenia shares some genetic risk and clinical symptoms with bipolar disorder. Clinical heterogeneity across subjects is thought to contribute to variable structural imaging findings across studies. The c...

Authors: Douglass Godwin, Kathryn I. Alpert, Lei Wang and Daniel Mamah

Lack of emotional gaze preferences using eye-tracking in remitted bipolar I disorder

Bipolar disorder is associated with heightened and persistent positive emotion (Gruber in Curr Dir Psychol Sci 20:217–221, 2011; Johnson in Clin Psychol Rev 25:241–262, 2005). Yet little is known about informatio...

Authors: John R. Purcell, Monika Lohani, Christie Musket, Aleena C. Hay, Derek M. Isaacowitz and June Gruber

Aripiprazole once-monthly as maintenance treatment for bipolar I disorder: a 52-week, multicenter, open-label study

The long-acting injectable antipsychotic aripiprazole once-monthly 400 mg (AOM 400) was recently approved for maintenance treatment of bipolar I disorder (BP-I). The purpose of this study was to evaluate the s...

Authors: Joseph R. Calabrese, Na Jin, Brian Johnson, Pedro Such, Ross A. Baker, Jessica Madera, Peter Hertel, Jocelyn Ottinger, Joan Amatniek and Hiroaki Kawasaki

The perspectives of patients with lithium-induced end-stage renal disease

Lithium is the treatment of choice for patients suffering from bipolar disorder (BD) but prolonged use induces renal dysfunction in at least 20% of patient. Intensive monitoring of kidney functioning helps to ...

Authors: Angèle P. M. Kerckhoffs, Erwin G. T. M. Hartong and Koen P. Grootens

Behavioural biomarkers and mobile mental health: a new paradigm

Over recent decades, the field of psychiatry has allocated a vast amount of resources and efforts to make available more accurate and objective methods to diagnose, assess and monitor treatment outcomes in psy...

Authors: Diego Hidalgo-Mazzei, Allan H. Young, Eduard Vieta and Francesc Colom

Regularity of self-reported daily dosage of mood stabilizers and antipsychotics in patients with bipolar disorder

Polypharmacy is often prescribed for bipolar disorder, yet medication non-adherence remains a serious problem. This study investigated the regularity in the daily dosage taken of mood stabilizers and second ge...

Authors: Maximilian Pilhatsch, Tasha Glenn, Natalie Rasgon, Martin Alda, Kemal Sagduyu, Paul Grof, Rodrigo Munoz, Wendy Marsh, Scott Monteith, Emanuel Severus, Rita Bauer, Philipp Ritter, Peter C. Whybrow and Michael Bauer

Monitoring of patients treated with lithium for bipolar disorder: an international survey

Adequate monitoring of patients using lithium is needed for optimal dosing and for early identification of patients with (potential) ADEs. The objective was to internationally assess how health care profession...

Authors: M. Nederlof, E. R. Heerdink, A. C. G. Egberts, I. Wilting, L. J. Stoker, R. Hoekstra and R. W. Kupka

Add-on treatment with N-acetylcysteine for bipolar depression: a 24-week randomized double-blind parallel group placebo-controlled multicentre trial (NACOS-study protocol)

Oxidative stress and inflammation may be involved in the development and progression of mood disorders, including bipolar disorder. Currently, there is a scarcity of useful treatment options for bipolar depres...

Authors: Pernille Kempel Ellegaard, Rasmus Wentzer Licht, Henrik Enghusen Poulsen, René Ernst Nielsen, Michael Berk, Olivia May Dean, Mohammadreza Mohebbi and Connie Thuroee Nielsen

Control charts for monitoring mood stability as a predictor of severe episodes in patients with bipolar disorder

Recurrent mood episodes and subsyndromal mood instability cause substantial disability in patients with bipolar disorder. Early identification of mood episodes enabling timely mood stabilization is an importan...

Authors: Maria D. L. A. Vazquez-Montes, Richard Stevens, Rafael Perera, Kate Saunders and John R. Geddes

Actigraphy as an objective intra-individual marker of activity patterns in acute-phase bipolar disorder: a case series

Actigraphy could be an objective alternative to clinical ratings of motor activity in bipolar disorder (BD), which is of importance now that increased activity and energy are added as cardinal symptoms of (hyp...

Authors: Karoline Krane-Gartiser, Andreas Asheim, Ole Bernt Fasmer, Gunnar Morken, Arne E. Vaaler and Jan Scott

Circulating antithyroid antibodies contribute to the decrease of glomerular filtration rate in lithium-treated patients: a longitudinal study

Concerns about the adverse effects of long-term treatment with lithium include reduced renal function. In the present study, we examined comorbidities which may be associated with chronic kidney disease in a c...

Authors: Alberto Bocchetta, Luca Ambrosiani, Gioia Baggiani, Claudia Pisanu, Caterina Chillotti, Raffaella Ardau, Fernanda Velluzzi, Doloretta Piras, Andrea Loviselli and Antonello Pani

The association between mood state and chronobiological characteristics in bipolar I disorder: a naturalistic, variable cluster analysis-based study

Multiple types of chronobiological disturbances have been reported in bipolar disorder, including characteristics associated with general activity levels, sleep, and rhythmicity. Previous studies have focused ...

Authors: Robert Gonzalez, Trisha Suppes, Jamie Zeitzer, Colleen McClung, Carol Tamminga, Mauricio Tohen, Angelica Forero, Alok Dwivedi and Andres Alvarado

Resilience concepts in psychiatry demonstrated with bipolar disorder

The term resilience describes stress–response patterns of subjects across scientific disciplines. In ecology, advances have been made to clearly distinguish resilience definitions based on underlying mechanist...

Authors: David G. Angeler, Craig R. Allen and Maj-Liz Persson

Smartphone-based objective monitoring in bipolar disorder: status and considerations

In 2001, the WHO stated that: “The use of mobile and wireless technologies to support the achievement of health objectives (mHealth) has the potential to transform the face of health service delivery across th...

Authors: Maria Faurholt-Jepsen, Michael Bauer and Lars Vedel Kessing

Association between CRP genetic diversity and bipolar disorder comorbid complications

Chronic low-grade inflammation is believed to contribute, at least in a subset of patients, to the development of bipolar disorder (BD). In this context, the most investigated biological marker is the acute ph...

Authors: Wahid Boukouaci, José Oliveira, Bruno Etain, Meriem Bennabi, Christina Mariaselvam, Nora Hamdani, Céline Manier, Djaouida Bengoufa, Frank Bellivier, Chantal Henry, Jean-Pierre Kahn, Dominique Charron, Rajagopal Krishnamoorthy, Marion Leboyer and Ryad Tamouza

Interrater reliability in bipolar disorder research: current practices and suggestions for enhancing best practices

Authors: June Gruber and Lauren M. Weinstock