Articles

The futility of long-term predictions in bipolar disorder: mood fluctuations are the result of deterministic chaotic processes

Understanding the underlying architecture of mood regulation in bipolar disorder (BD) is important, as we are starting to conceptualize BD as a more complex disorder than one of recurring manic or depressive e...

Authors: Abigail Ortiz, Kamil Bradler, Maxine Mowete, Stephane MacLean, Julie Garnham, Claire Slaney, Benoit H. Mulsant and Martin Alda

Using density of antecedent events and trajectory path analysis to investigate family-correlated patterns of onset of bipolar I disorder: a comparison of cohorts from Europe and USA

Major contributors to the global burden of bipolar disorders (BD) are the early age at onset (AAO) and the co-occurrence of non-mood disorders before and after the onset of BD. Using data from two independent ...

Authors: Jan Scott, Florence Vorspan, Josephine Loftus, Frank Bellivier and Bruno Etain

Late chronotype predicts more depressive symptoms in bipolar disorder over a 5 year follow-up period

There is increasing evidence that bipolar disorder is influenced by circadian timing, including the timing of sleep and waking activities. Previous studies in bipolar disorder have shown that people with later...

Authors: Parisa Vidafar, Anastasia K. Yocum, Peisong Han, Melvin G. McInnis and Helen J. Burgess

Valproic acid autoinduction: a case-based review

Although valproic acid (VPA) induces the metabolism of multiple other drugs, the clinical reports of VPA autoinduction are rare. A comprehensive literature search yielded only one published case series, which ...

Authors: Sean Bennett and Mujeeb U. Shad

Variations in seasonal solar insolation are associated with a history of suicide attempts in bipolar I disorder

Bipolar disorder is associated with circadian disruption and a high risk of suicidal behavior. In a previous exploratory study of patients with bipolar I disorder, we found that a history of suicide attempts w...

Authors: Michael Bauer, Tasha Glenn, Eric D. Achtyes, Martin Alda, Esen Agaoglu, Kürşat Altınbaş, Ole A. Andreassen, Elias Angelopoulos, Raffaella Ardau, Edgar Arrua Vares, Memduha Aydin, Yavuz Ayhan, Christopher Baethge, Rita Bauer, Bernhard T. Baune, Ceylan Balaban…

Lurasidone in the long-term treatment of Japanese patients with bipolar I disorder: a 52 week open label study

The current study evaluated the long-term (52 week) safety and impact on symptom measures of lurasidone (with or without lithium or valproate) for the treatment of bipolar I disorder in Japanese patients.

Authors: Teruhiko Higuchi, Tadafumi Kato, Mari Miyajima, Kei Watabe, Takahiro Masuda, Katsuhiko Hagi and Jun Ishigooka

Is the 4-factor model of symptomology equivalent across bipolar disorder subtypes?

Research with the BDS_x (Bipolar Disorder Symptom Scale) suggests a 4-factor structure of responses: two depression (cognitive, somatic) and two hypo/mania factors (elation/loss of insight, affrontive symptoms). T...

Authors: Norm O’Rourke, Andrew Sixsmith, Tal Michael and Yaacov G. Bachner

Early detection of bipolar disorders and treatment recommendations for help-seeking adolescents and young adults: Findings of the Early Detection and Intervention Center Dresden

Early identification and intervention of individuals with risk factors for or subtle prodromal symptoms of bipolar disorders (BD) may improve the illness course and prevent adverse long-term consequences.

Authors: Julia Martini, Karolina Leopold, Steffi Pfeiffer, Christina Berndt, Anne Boehme, Veit Roessner, Paolo Fusar-Poli, Allan H. Young, Christoph U. Correll, Michael Bauer and Andrea Pfennig

Predicting the risk and timing of major mood disorder in offspring of bipolar parents: exploring the utility of a neural network approach

Bipolar disorder onset peaks over early adulthood and confirmed family history is a robust risk factor. However, penetrance within families varies and most children of bipolar parents will not develop the illn...

Authors: Alysha Cooper, Julie Horrocks, Sarah Goodday, Charles Keown-Stoneman and Anne Duffy

Psychological therapy for mood instability within bipolar spectrum disorder: a randomised, controlled feasibility trial of a dialectical behaviour therapy-informed approach (the ThrIVe-B programme)

A subgroup of those with bipolar spectrum disorders experience ongoing mood fluctuations outside of full episodes. We conducted a randomised, controlled feasibility study of a Dialectical Behavioural Therapy-i...

Authors: Kim Wright, Alyson L. Dodd, Fiona C. Warren, Antonieta Medina-Lara, Barnaby Dunn, Julie Harvey, Mahmood Javaid, Steven H. Jones, Christabel Owens, Rod S. Taylor, Deborah Duncan, Alexandra Newbold, Shelley Norman, Faith Warner and Thomas R. Lynch

‘Pediatric Bipolar Disorder’ rates are still lower than claimed: a re-examination of eight epidemiological surveys used by an updated meta-analysis

‘Pediatric bipolar disorder’ (PBD) is a controversial diagnosis with varying rates of clinical diagnosis. A highly cited meta-analysis (Van Meter et al. 2011) of a dozen epidemiological surveys suggested a glo...

Authors: Peter Parry, Stephen Allison and Tarun Bastiampillai

Patients’ adherence to smartphone apps in the management of bipolar disorder: a systematic review

Despite an increasing number of available mental health apps in the bipolar disorder field, these tools remain scarcely implemented in everyday practice and are quickly discontinued by patients after downloadi...

Authors: Marie-Camille Patoz, Diego Hidalgo-Mazzei, Bruno Pereira, Olivier Blanc, Ingrid de Chazeron, Andrea Murru, Norma Verdolini, Isabella Pacchiarotti, Eduard Vieta, Pierre-Michel Llorca and Ludovic Samalin

Regional lithium prescription rates and recurrence in bipolar disorder

Lithium is the best documented maintenance treatment in bipolar disorder, but its use varies considerably across and within countries. It is not known whether regional differences in lithium prescription rates...

Authors: Martin Sköld, Sindre Rolstad, Erik Joas, Mathias Kardell, Erik Pålsson, Guy M. Goodwin and Mikael Landén

Psychological symptoms during and after Austrian first lockdown in individuals with bipolar disorder? A follow-up control-group investigation

The coronavirus disease (COVID-19) pandemic, a global health crisis, has resulted in widespread socioeconomic restrictions including lockdown, social distancing, and self-isolation. To date, little is known ab...

Authors: Nina Dalkner, Jolana Wagner-Skacel, Michaela Ratzenhofer, Frederike Fellendorf, Melanie Lenger, Alexander Maget, Adelina Tmava-Berisha, René Pilz, Robert Queissner, Carlo Hamm, Susanne Bengesser, Martina Platzer, Armin Birner and Eva Reininghaus

Evaluating endophenotypes for bipolar disorder

Phenotypic heterogeneity is a major impediment to the elucidation of the neurobiology and genetics of bipolar disorder. Endophenotype could help in reducing heterogeneity by defining biological traits that are...

Authors: Riccardo Guglielmo, Kamilla Woznica Miskowiak and Gregor Hasler

Deficits in explicit emotion regulation in bipolar disorder: a systematic review

This study aimed to compile and synthesize studies investigating explicit emotion regulation in patients with bipolar disorder and individuals at risk of developing bipolar disorder. The importance of explicit...

Authors: Marcel Kurtz, Pia Mohring, Katharina Förster, Michael Bauer and Philipp Kanske

Impact of modification to DSM-5 criterion A for hypomania/mania in newly diagnosed bipolar patients: findings from the prospective BIO study

DSM-IV states that criterion A for diagnosing hypomania/mania is mood change. The revised DSM-5 now states that increased energy or activity must be present alongside mood changes to diagnose hypomania/mania, ...

Authors: Mette U. Fredskild, Sharleny Stanislaus, Klara Coello, Sigurd A. Melbye, Hanne Lie Kjærstad, Kimie Stefanie Ormstrup Sletved, Trisha Suppes, Maj Vinberg and Lars Vedel Kessing

25 Years of the International Bipolar Collaborative Network (BCN)

The Stanley Foundation Bipolar Treatment Outcome Network (SFBN) recruited more than 900 outpatients from 1995 to 2002 from 4 sites in the United States (US) and 3 in the Netherlands and Germany (abbreviated as...

Authors: Robert M. Post, Lori L. Altshuler, Ralph Kupka, Susan L. McElroy, Mark A. Frye, Heinz Grunze, Trisha Suppes, Paul E. Keck Jr and Willem A. Nolen

Transdiagnostic comparison of visual working memory capacity in bipolar disorder and schizophrenia

Impaired working memory is a core cognitive deficit in both bipolar disorder and schizophrenia. Its study might yield crucial insights into the underpinnings of both disorders on the cognitive and neurophysiol...

Authors: Catherine V. Barnes-Scheufler, Caroline Passow, Lara Rösler, Jutta S. Mayer, Viola Oertel, Sarah Kittel-Schneider, Silke Matura, Andreas Reif and Robert A. Bittner

Internet of things issues related to psychiatry

Internet of Things (IoT) devices for remote monitoring, diagnosis, and treatment are widely viewed as an important future direction for medicine, including for bipolar disorder and other mental illness. The nu...

Authors: Scott Monteith, Tasha Glenn, John Geddes, Emanuel Severus, Peter C. Whybrow and Michael Bauer

Overview of lithium's use: a nationwide survey

Lithium is considered the gold standard treatment for bipolar disorder (BD). Current clinical guidelines and scientific evidence support its use as a first-line treatment in BD. However, over the last two deca...

Authors: Xabier Pérez de Mendiola, Diego Hidalgo-Mazzei, Eduard Vieta and Ana González-Pinto

Prefrontal dopamine D1 receptor manipulation influences anxiety behavior and induces neuroinflammation within the hippocampus

Prefrontal dopamine D1 receptor (D1R) mediates behavior related to anxiety, reward and memory, and is involved in inflammatory processes, all of which are affected in bipolar disorder. Interleukin-6 (IL-6), a ...

Authors: Dominik K. E. Beyer, Annika Mattukat and Nadja Freund

Associations between the cortisol awakening response and patient-evaluated stress and mood instability in patients with bipolar disorder: an exploratory study

The Cortisol Awakening Response (CAR) measured as the transient increase in cortisol levels following morning awakening appears to be a distinct feature of the HPA axis. Patients with bipolar disorder (BD) exp...

Authors: Maria Faurholt-Jepsen, Vibe Gedsø Frøkjær, Arafat Nasser, Niklas Rye Jørgensen, Lars Vedel Kessing and Maj Vinberg

Melanopsin-mediated pupillary responses in bipolar disorder—a cross-sectional pupillometric investigation

Visible light, predominantly in the blue range, affects mood and circadian rhythm partly by activation of the melanopsin-containing intrinsically photosensitive retinal ganglion cells (ipRGCs). The light-induc...

Authors: Helle Østergaard Madsen, Shakoor Ba-Ali, Steffen Heegaard, Ida Hageman, Ulla Knorr, Henrik Lund-Andersen, Klaus Martiny and Lars Vedel Kessing

Role of endogenous ouabain in the etiology of bipolar disorder

Bipolar disorder is a severe psychiatric illness with poor prognosis and problematic and suboptimal treatments. Understanding the pathoetiologic mechanisms may improve treatment and outcomes.

Authors: Rif S. El-Mallakh, Yonglin Gao and Pan You

Blood pressure in bipolar disorder: evidence of elevated pulse pressure and associations between mean pressure and mood instability

Bipolar disorder (BD) is associated with excess and premature cardiovascular mortality. Elevated blood pressure (BP) is a leading contributor to cardiovascular risk. However, few studies have examined BP in BD...

Authors: Niall M. McGowan, Molly Nichols, Amy C. Bilderbeck, Guy M. Goodwin and Kate E. A. Saunders

Respiratory infections during lithium and valproate medication: a within-individual prospective study of 50,000 patients with bipolar disorder

In vitro studies have demonstrated that lithium has antiviral properties, but evidence from human studies is scarce. Lithium is used as a mood stabilizer to treat patients with bipolar disorder. Here, the aim ...

Authors: Mikael Landén, Henrik Larsson, Paul Lichtenstein, Johan Westin and Jie Song

Has Bipolar Disorder become a predominantly female gender related condition? Analysis of recently published large sample studies

Bipolar Disorders (BD) are disabling and severe psychiatric disorders, commonly perceived as equally affecting both men and women. The prevalence of BD in the general population has been growing over the last ...

Authors: Bernardo Dell’Osso, Rita Cafaro and Terence A. Ketter

A pilot investigation of emotional regulation difficulties and mindfulness-based strategies in manic and remitted bipolar I disorder and major depressive disorder

Both bipolar disorder and major depressive disorder are characterized by difficulties in emotion regulation. Little is known about which specific emotion regulatory patterns may be transdiagnostic versus disor...

Authors: Christie W. Musket, Natasha S. Hansen, Keith M. Welker, Kirsten E. Gilbert and June Gruber

Chronic kidney disease in lithium-treated patients, incidence and rate of decline

Lithium-induced nephropathy is a known long-term complication, sometimes limiting the use of lithium as mood stabilizer. The aim of this study is to establish the incidence of chronic kidney disease and the ra...

Authors: Arjan M. Van Alphen, Tessa M. Bosch, Ralph W. Kupka and Rocco Hoekstra

Socio-demographic and clinical predictors of outcome to long-term treatment with lithium in bipolar disorders: a systematic review of the contemporary literature and recommendations from the ISBD/IGSLI Task Force on treatment with lithium

To identify possible socio-demographic and clinical factors associated with Good Outcome (GO) as compared with Poor Outcome (PO) in adult patients diagnosed with Bipolar Disorder (BD) who received long-term tr...

Authors: Diane Grillault Laroche, Bruno Etain, Emanuel Severus, Jan Scott and Frank Bellivier

Digital health developments and drawbacks: a review and analysis of top-returned apps for bipolar disorder

Although a growing body of literature highlights the potential benefit of smartphone-based mobile apps to aid in self-management and treatment of bipolar disorder, it is unclear whether such evidence-based app...

Authors: Sarah Lagan, Abinaya Ramakrishnan, Evan Lamont, Aparna Ramakrishnan, Mark Frye and John Torous

Recommendations for the use of long-term experience sampling in bipolar disorder care: a qualitative study of patient and clinician experiences

Self-monitoring has been shown to improve the self-management and treatment of patients with bipolar disorder. However, current self-monitoring methods are limited to once-daily retrospectively assessed mood, ...

Authors: Fionneke M. Bos, Evelien Snippe, Richard Bruggeman, Bennard Doornbos, Marieke Wichers and Lian van der Krieke

An evidence map of actigraphy studies exploring longitudinal associations between rest-activity rhythms and course and outcome of bipolar disorders

Evidence mapping is a structured approach used to synthesize the state-of-the-art in an emerging field of research when systematic reviews or meta-analyses are deemed inappropriate. We employed this strategy t...

Authors: Jan Scott, Francesc Colom, Allan Young, Frank Bellivier and Bruno Etain

Defining phenotypes of long-term lithium and valproate response, including combination therapy: a modified application of the Alda scale in patients with bipolar disorders

When evaluating the long-term treatment response to mood stabilizers using the Alda scale, mood stabilizer combination therapy is typically considered a confounding factor, and patients receiving combination t...

Authors: Jinyoung Lee, Ji Hyun Baek, Dongbin Lee, Sung Woo Ahn, So-Yung Yang, Yujin Choi, Yong Chun Bahk and Kyung Sue Hong

Misperception of sleep in bipolar disorder: an exploratory study using questionnaire versus actigraphy

The concept of misperception of sleep refers to the estimated discrepancy between subjective and objective measures of sleep. This has been assessed only in a few prior studies in individuals with Bipolar Diso...

Authors: Henrik Myhre Ihler, Manon Meyrel, Vincent Hennion, Julia Maruani, Gregory Gross, Pierre A. Geoffroy, Trine Vik Lagerberg, Ingrid Melle, Frank Bellivier, Jan Scott and Bruno Etain

Digital phenotyping: towards replicable findings with comprehensive assessments and integrative models in bipolar disorders

Digital phenotyping promises to unobtrusively obtaining a continuous and objective input of symptomatology from patients’ daily lives. The prime example are bipolar disorders, as smartphone parameters directly...

Authors: Ulrich W. Ebner-Priemer, Esther Mühlbauer, Andreas B. Neubauer, Holger Hill, Fabrice Beier, Philip S. Santangelo, Philipp Ritter, Nikolaus Kleindienst, Michael Bauer, Florian Schmiedek and Emanuel Severus

The feasibility of mindfulness-based cognitive therapy for people with bipolar disorder: a qualitative study

Mindfulness- Based Cognitive Therapy (MBCT) could be a promising psychosocial intervention for people with bipolar disorder (BD). However, little is known about the feasibility of MBCT for people with BD. In t...

Authors: Imke Hanssen, Nicole van der Horst, Marieke Boele, Marc Lochmann van Bennekom, Eline Regeer and Anne Speckens

Smartphone-based activity measurements in patients with newly diagnosed bipolar disorder, unaffected relatives and control individuals

In DSM-5 activity is a core criterion for diagnosing hypomania and mania. However, there are no guidelines for quantifying changes in activity. The objectives of the study were (1) to investigate daily smartph...

Authors: Sharleny Stanislaus, Maj Vinberg, Sigurd Melbye, Mads Frost, Jonas Busk, Jakob E. Bardram, Lars Vedel Kessing and Maria Faurholt-Jepsen

New vision on the mental problems of Vincent van Gogh; results from a bottom-up approach using (semi-)structured diagnostic interviews

On July 29, 1890 at the age of 37 years, the Dutch painter Vincent van Gogh died from the consequences of a suicide attempt with a gun 2 days earlier. Since then many medical and psychological theories were su...

Authors: Willem A. Nolen, Erwin van Meekeren, Piet Voskuil and Willem van Tilburg

Patient-evaluated cognitive function measured with smartphones and the association with objective cognitive function, perceived stress, quality of life and function capacity in patients with bipolar disorder

Cognitive impairments in patients with bipolar disorder (BD) have been associated with reduced functioning. Aims: To investigate the association between (1) patient-evaluated cognitive function measured daily ...

Authors: Maria Faurholt-Jepsen, Kamilla Woznica Miskowiak, Mads Frost, Ellen Margrethe Christensen, Helga Þórarinsdóttir, Jakob Eyvind Bardram, Maj Vinberg and Lars Vedel Kessing

Survey of psychiatrist use of digital technology in clinical practice

Psychiatrists were surveyed to obtain an overview of how they currently use technology in clinical practice, with a focus on psychiatrists who treat patients with bipolar disorder.

Authors: Rita Bauer, Tasha Glenn, Scott Monteith, Peter C. Whybrow and Michael Bauer

Reliability and validity of the functioning assessment short test for older adults with bipolar disorder (FAST-O)

Many frequently used instruments fail to assess psychosocial functioning in patients with bipolar disorder. The Functioning Assessment Short Test (FAST) was developed in order to tackle this problem and to ass...

Authors: Melis Orhan, Nicole Korten, Ralph Kupka, Patricia van Oppen, Max Stek, Eduard Vieta, Sigfried Schouws, Wouter van Ballegooijen and Annemiek Dols

A multi-center naturalistic study of a newly designed 12-sessions group psychoeducation program for patients with bipolar disorder and their caregivers

Psychoeducation (PE) for bipolar disorder (BD) has a first-line recommendation for the maintenance treatment phase of BD. Formats vary greatly in the number of sessions, whether offered individually or in a gr...

Authors: Susan Zyto, Nienke Jabben, Peter F. J. Schulte, Eline J. Regeer, Peter J. J. Goossens and Ralph W. Kupka

Bipolar offspring and mothers: interactional challenges at infant age 3 and 12 months—a developmental pathway to enhanced risk?

Bipolar offspring are considered a high-risk group for developing mental disorders. Developmental outcomes result from additive and interactive effects of biological vulnerability and environmental influences....

Authors: Teija M. S. Anke, Kari Slinning, Vibeke Moe, Cathrine Brunborg, Torill S. Siqveland and Dag Vegard Skjelstad

Low-dose lithium against dementia

Authors: Christopher Baethge

FAB: First UK feasibility trial of a future randomised controlled trial of Family focused treatment for Adolescents with Bipolar disorder

This first mixed-methods UK trial examined the feasibility and acceptability of a future definitive randomised controlled trial (RCT) to evaluate whether Family Focussed Treatment for Adolescents with Bipolar ...

Authors: A. Sharma, M. Glod, T. Forster, R. McGovern, K. McGurk, E. Barron Millar, T. D. Meyer, D. Miklowitz, V. Ryan, L. Vale and A. Le Couteur

Potential pharmacogenomic targets in bipolar disorder: considerations for current testing and the development of decision support tools to individualize treatment selection

Treatment in bipolar disorder (BD) is commonly applied as a multimodal therapy based on decision algorithms that lack an integrative understanding of molecular mechanisms or a biomarker associated clinical out...

Authors: Alfredo B. Cuéllar-Barboza, Susan L. McElroy, Marin Veldic, Balwinder Singh, Simon Kung, Francisco Romo-Nava, Nicolas A. Nunez, Alejandra Cabello-Arreola, Brandon J. Coombes, Miguel Prieto, Hannah K. Betcher, Katherine M. Moore, Stacey J. Winham, Joanna M. Biernacka and Mark A. Frye

Improving early recognition and intervention in people at increased risk for the development of bipolar disorder: study protocol of a prospective-longitudinal, naturalistic cohort study (Early-BipoLife)

Bipolar disorders (BD) belong to the most severe mental disorders, characterized by an early onset and recurrent, severe episodes or a chronic course with poor psychosocial functioning in a proportion of patie...

Authors: Andrea Pfennig, Karolina Leopold, Julia Martini, Anne Boehme, Martin Lambert, Thomas Stamm, Felix Bermpohl, Andreas Reif, Sarah Kittel-Schneider, Georg Juckel, Andreas J. Fallgatter, Tilo Kircher, Andreas Jansen, Steffi Pfeiffer, Christina Berndt, Maren Rottmann-Wolf…

Treating winter depressive episodes in bipolar disorder: an open trial of light therapy

Light therapy has been used to treat winter depression in bipolar disorder, although the dose, duration, and timing of treatment have differed. The present study is an open trial of light therapy for depressiv...

Authors: Lotte J. E. van Hout, Lisette E. P. Rops and Claudia J. P. Simons