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  1. PER3 is a circadian gene that contains a variable number of tandem repeats (VNTR) which codifies for three genotypes: 4/4; 4/5; and 5/5 and is involved in non-visual response to light, a critical process associat...

    Authors: Tommaso Barlattani, Bettina Soltmann, Chiara D’Amelio, Valentina Socci, Francesca Pacitti, Maurizio Pompili and Philipp Ritter
    Citation: International Journal of Bipolar Disorders 2024 12:25
  2. Authors: Delfina Janiri, Alessio Simonetti, Mario Luciano, Silvia Montanari, Evelina Bernardi, Giuseppe Carrà, Andrea Fiorillo and Gabriele Sani
    Citation: International Journal of Bipolar Disorders 2024 12:24

    The original article was published in International Journal of Bipolar Disorders 2024 12:10

  3. Decades of clinical research have demonstrated the efficacy of lithium in treating acute episodes (both manic and depressive), as well as in preventing recurrences of bipolar disorder (BD). Specific to lithium...

    Authors: Mirko Manchia, Pasquale Paribello, Martina Pinna, Luca Steardo Jr., Bernardo Carpiniello, Federica Pinna, Claudia Pisanu, Alessio Squassina and Tomas Hajek
    Citation: International Journal of Bipolar Disorders 2024 12:23
  4. Mitochondrial dysfunction is implicated in the neuropathology of bipolar disorder (BD). Higher circulating cell-free mitochondrial DNA (ccf-mtDNA), generally reflecting poorer mitochondrial health, has been as...

    Authors: Suyi Shao, Yi Zou, Kody G. Kennedy, Mikaela K. Dimick, Ana C. Andreazza, L. Trevor Young, Vanessa F. Goncalves, Bradley J. MacIntosh and Benjamin I. Goldstein
    Citation: International Journal of Bipolar Disorders 2024 12:21
  5. Lithium (Li) remains the treatment of choice for bipolar disorders (BP). Its mood-stabilizing effects help reduce the long-term burden of mania, depression and suicide risk in patients with BP. It also has bee...

    Authors: Marisol Herrera-Rivero, Mazda Adli, Kazufumi Akiyama, Nirmala Akula, Azmeraw T. Amare, Raffaella Ardau, Bárbara Arias, Jean-Michel Aubry, Lena Backlund, Frank Bellivier, Antonio Benabarre, Susanne Bengesser, Abesh Kumar Bhattacharjee, Joanna M. Biernacka, Armin Birner, Micah Cearns…
    Citation: International Journal of Bipolar Disorders 2024 12:20
  6. Several genetic studies have been undertaken to elucidate the intricate interplay between genetics and drug responses in bipolar disorder (BD). However, there has been notably limited research on biomarkers sp...

    Authors: Hyunju Lee, Dohyun Han, Kyung Sue Hong, Kyooseob Ha, Hyeyoon Kim, Eun Young Cho, Woojae Myung, Sang Jin Rhee, Jayoun Kim, Tae Hyon Ha, Kang Eun Lee, Hye Won Jung, Yejin Lee, Dongbin Lee, Hyeona Yu, Daseul Lee…
    Citation: International Journal of Bipolar Disorders 2024 12:19
  7. Bipolar disorder (BD) is a severe psychiatric disorder characterized by changes in mood that alternate between (hypo) mania or depression and mixed states, often associated with functional impairment and cogni...

    Authors: Anaid Pérez-Ramos, Cristina Romero-López-Alberca, Maria Hidalgo-Figueroa, Esther Berrocoso and Jose I. Pérez-Revuelta
    Citation: International Journal of Bipolar Disorders 2024 12:18
  8. Lithium is effective in the long-term treatment of bipolar disorder. Concerns have been raised about non-responsiveness after discontinuation and resuming previously effective lithium prophylaxis. We reviewed ...

    Authors: Ralph Kupka, Eline Regeer, Annet van Bergen, Leonardo Tondo and Michael Bauer
    Citation: International Journal of Bipolar Disorders 2024 12:17
  9. Red onion husk, a readily available agricultural waste material, contains diverse bioactive compounds with potential health benefits. This study aimed to assess the safety and therapeutic potential of red onio...

    Authors: Chukwuma Raphael Ekeanyanwu, Chidinma Lynda Ekeanyanwu and Kingsley Nnaemeka Ugochukwu
    Citation: International Journal of Bipolar Disorders 2024 12:16
  10. BIPCOM aims to (1) identify medical comorbidities in people with bipolar disorder (BD); (2) examine risk factors and clinical profiles of Medical Comorbidities (MC) in this clinical group, with a special focus...

    Authors: Giovanni de Girolamo, Ole A. Andreassen, Michael Bauer, Paolo Brambilla, Stefano Calza, Nicholas Citerà, Rosa Corcoy, Andrea Fagiolini, Miguel Garcia-Argibay, Ophélia Godin, Florian Klingler, Nene F. Kobayashi, Henrik Larsson, Marion Leboyer, Silke Matura, Alessandra Martinelli…
    Citation: International Journal of Bipolar Disorders 2024 12:15
  11. This is an overview of recent advances on predominant polarity conceptualization in bipolar disorder (BD). Current evidence on its operationalized definitions, possible contextualization within the affective s...

    Authors: Francesco Bartoli, Gin S. Malhi and Giuseppe Carrà
    Citation: International Journal of Bipolar Disorders 2024 12:14
  12. Bipolar disorder (BD) is a severe mental disorder related to neurocognitive deficits. Exposure to childhood trauma is associated with worse cognitive performance. Different compositions of childhood trauma in ...

    Authors: Yuan-Zhi Hsueh, Cho-Yin Huang, Po-Hsiu Kuo, Ying-Chih Cheng, Ming-Chyi Huang, Chih Chiang Chiu, Chian-Jue Kuo, Po-Yu Chen and Wen-Yin Chen
    Citation: International Journal of Bipolar Disorders 2024 12:13
  13. Bipolar disorder is a broad diagnostic construct associated with significant phenotypic and genetic heterogeneity challenging progress in clinical practice and discovery research. Prospective studies of well-c...

    Authors: Anne Duffy and Paul Grof
    Citation: International Journal of Bipolar Disorders 2024 12:12
  14. Rapid cycling bipolar disorder (RCBD), characterized by four or more episodes per year, is a complex subtype of bipolar disorder (BD) with poorly understood characteristics.

    Authors: Jin-jie Xu, Xue-quan Zhu, Shuang Liu, Lu-yu Ding, Bing-bing Fu, Cong-cong Sun, Yan-li Pan, Wei Wang and Ling Zhang
    Citation: International Journal of Bipolar Disorders 2024 12:11
  15. Lithium stands as the gold standard in treating bipolar disorders (BD). Despite numerous clinical factors being associated with a favorable response to lithium, comprehensive studies examining the collective i...

    Authors: Delfina Janiri, Alessio Simonetti, Mario Luciano, Silvia Montanari, Evelina Bernardi, Giuseppe Carrà, Andrea Fiorillo and Gabriele Sani
    Citation: International Journal of Bipolar Disorders 2024 12:10

    The Correction to this article has been published in International Journal of Bipolar Disorders 2024 12:24

  16. Multiple traumatic experiences, particularly in childhood, may predict and be a risk factor for the development of complex post-traumatic stress disorder (cPTSD). Unfortunately, individuals with bipolar disord...

    Authors: Anna Maria Iazzolino, Marta Valenza, Martina D’Angelo, Grazia Longobardi, Valeria Di Stefano, Steardo Luca, Caterina Scuderi and Luca Steardo jr
    Citation: International Journal of Bipolar Disorders 2024 12:9
  17. The suicide rate in bipolar disorder (BD) is among the highest across all psychiatric disorders. Identifying modifiable variables that relate to suicidal thoughts and behaviors (STBs) in BD may inform preventi...

    Authors: Chelsea K. Pike, Katherine E. Burdick, Caitlin Millett and Jessica M. Lipschitz
    Citation: International Journal of Bipolar Disorders 2024 12:8
  18. The phenomenon of preventing the recurrences of mood disorders by the long-term lithium administration was discovered sixty years ago. Such a property of lithium has been unequivocally confirmed in subsequent ...

    Authors: Ewa Ferensztajn-Rochowiak, Ute Lewitzka, Maria Chłopocka-Woźniak and Janusz K. Rybakowski
    Citation: International Journal of Bipolar Disorders 2024 12:7
  19. Systemic inflammation-immune dysregulation and brain abnormalities are believed to contribute to the pathogenesis of bipolar disorder (BD). However, the connections between peripheral inflammation and the brai...

    Authors: Jing-Yi Long, Bo Li, Pei Ding, Hao Mei and Yi Li
    Citation: International Journal of Bipolar Disorders 2024 12:5
  20. Abnormalities in cerebrospinal fluid (CSF)-amyloid-beta (Aβ)42, CSF-Aβ40, CSF-Aβ38, CSF-soluble amyloid precursor proteins α and β, CSF-total-tau, CSF-phosphorylated-tau, CSF-neurofilament light protein (NF-L)...

    Authors: Ulla Knorr, Anja Hviid Simonsen, Henrik Zetterberg, Kaj Blennow, Mira Willkan, Julie Forman, Kamilla Miskowiak, Steen Gregers Hasselbalch and Lars Vedel Kessing
    Citation: International Journal of Bipolar Disorders 2024 12:2
  21. Social anxiety disorder increases the likelihood of unfavourable outcomes in people with bipolar disorder. Cognitive behavioural therapy (CBT) is the first-line treatment for social anxiety disorder. However, ...

    Authors: Barbara Pavlova, Emma Warnock-Parkes, Martin Alda, Rudolf Uher and David M. Clark
    Citation: International Journal of Bipolar Disorders 2024 12:1
  22. Lithium (Li) remains one of the most valuable treatment options for mood disorders. However, current knowledge about prescription practices in Germany is limited. The objective of this study is to estimate the...

    Authors: Paul Kriner, Emanuel Severus, Julie Korbmacher, Lisa Mußmann and Florian Seemueller
    Citation: International Journal of Bipolar Disorders 2023 11:40
  23. Factors associated with suicide attempts during the antecedent illness trajectory of bipolar disorder (BD) and schizophrenia (SZ) are poorly understood.

    Authors: Alessandro Miola, Manuel Gardea-Reséndez, Javier Ortiz-Orendain, Nicolas A. Nunez, Mete Ercis, Brandon J. Coombes, Manuel Fuentes Salgado, Peggy M. Gruhlke, Ian Michel, J. Michael Bostwick, Alastair J. McKean, Aysegul Ozerdem and Mark A. Frye
    Citation: International Journal of Bipolar Disorders 2023 11:38
  24. Bipolar disorder (BD) is often seen as a bridge between schizophrenia and depression in terms of symptomatology and etiology. Interestingly, hemispheric asymmetries as well as behavioral lateralization are shi...

    Authors: Annakarina Mundorf, Jette Borawski and Sebastian Ocklenburg
    Citation: International Journal of Bipolar Disorders 2023 11:37
  25. Neonatal effects of late intrauterine and early postpartum exposure to lithium through mother’s own milk are scarcely studied. It is unclear whether described symptoms in breastfed neonates are caused by place...

    Authors: Essi Whaites Heinonen, Katarina Tötterman, Karin Bäck, Ihsan Sarman, Lisa Forsberg and Jenny Svedenkrans
    Citation: International Journal of Bipolar Disorders 2023 11:36
  26. The impact of long-term lithium treatment on weight gain has been a controversial topic with conflicting evidence. We aim to assess reporting of weight gain associated with lithium and other mood stabilizers c...

    Authors: Waldemar Greil, Mateo de Bardeci, Bruno Müller-Oerlinghausen, Nadja Nievergelt, Hans Stassen, Gregor Hasler, Andreas Erfurth, Katja Cattapan, Eckart Rüther, Johanna Seifert, Sermin Toto, Stefan Bleich and Georgios Schoretsanitis
    Citation: International Journal of Bipolar Disorders 2023 11:34
  27. The differential diagnosis of patients presenting for the first time with a depressive episode into unipolar disorder versus bipolar disorder is crucial to establish the correct pharmacological therapy (antide...

    Authors: Gianluca Rosso, Giuseppe Maina, Elena Teobaldi, Ilaria Balbo, Gabriele Di Salvo, Francesca Montarolo, Nicola Rizzo Pesci, Filippo Tempia and Eriola Hoxha
    Citation: International Journal of Bipolar Disorders 2023 11:33
  28. Widely reported by bipolar disorder (BD) patients, cognitive symptoms, including deficits in executive function, memory, attention, and timing are under-studied. Work suggests that individuals with BD show imp...

    Authors: Victória A. Müller Ewald, Nicholas T. Trapp, McCall E. Sarrett, Benjamin D. Pace, Linder Wendt, Jenny G. Richards, Ilisa K. Gala, Jacob N. Miller, Jan R. Wessel, Vincent A. Magnotta, John A. Wemmie, Aaron D. Boes and Krystal L. Parker
    Citation: International Journal of Bipolar Disorders 2023 11:32
  29. Childhood trauma (CT) are frequently reported by patients with bipolar disorder (BD), but it is unclear whether and how CT contribute to patients’ cognitive and psychosocial impairments. We aimed to examine th...

    Authors: Kamilla Woznica Miskowiak, Katrine Bang Hansen, Johanna Mariegaard and Lars Vedel Kessing
    Citation: International Journal of Bipolar Disorders 2023 11:31
  30. For over half a century, it has been widely known that lithium is the most efficacious treatment for bipolar disorder. Yet, despite this, its prescription has consistently declined over this same period of tim...

    Authors: Gin S. Malhi, Erica Bell, Maedeh Jadidi, Michael Gitlin and Michael Bauer
    Citation: International Journal of Bipolar Disorders 2023 11:30
  31. We tested the hypothesis that, after initial improvement with intravenous ketamine in patients with bipolar disorder (BD) with severe depression and acute suicidal thinking or behavior, a fixed-dose combinatio...

    Authors: Andrew Nierenberg, Philip Lavin, Daniel C. Javitt, Richard Shelton, Michael T. Sapko, Sanjay Mathew, Robert E. Besthof and Jonathan C. Javitt
    Citation: International Journal of Bipolar Disorders 2023 11:28
  32. Intrusive mental imagery is associated with anxiety and mood instability within bipolar disorder and therefore represents a novel treatment target. Imagery Based Emotion Regulation (IBER) is a brief structured...

    Authors: Craig Steel, Kim Wright, Guy M. Goodwin, Judit Simon, Nicola Morant, Rod S. Taylor, Michael Brown, Susie Jennings, Susie A. Hales, Jemma Regan, Michaela Sibsey, Zoe Thomas, Lynette Meredith and Emily A. Holmes
    Citation: International Journal of Bipolar Disorders 2023 11:27
  33. Bipolar disorder (BD) and schizophrenia (SZ) are complex psychotic disorders (PSY), with both environmental and genetic factors including possible maternal inheritance playing a role. Some studies have investi...

    Authors: Ryobu Tachi, Kazutaka Ohi, Daisuke Nishizawa, Midori Soda, Daisuke Fujikane, Junko Hasegawa, Ayumi Kuramitsu, Kentaro Takai, Yukimasa Muto, Shunsuke Sugiyama, Kiyoyuki Kitaichi, Ryota Hashimoto, Kazutaka Ikeda and Toshiki Shioiri
    Citation: International Journal of Bipolar Disorders 2023 11:26
  34. The distinction between bipolar I and bipolar II disorder and its treatment implications have been a matter of ongoing debate. The aim of this study was to examine differences between patients with bipolar I a...

    Authors: Giulio Emilio Brancati, Abraham Nunes, Katie Scott, Claire O’Donovan, Pablo Cervantes, Paul Grof and Martin Alda
    Citation: International Journal of Bipolar Disorders 2023 11:25
  35. Lithium is the preferred treatment for pregnant women with bipolar disorders (BD), as it is most effective in preventing postpartum relapse. Although it has been prescribed during pregnancy for decades, the sa...

    Authors: Noralie N. Schonewille, Pleun A. Terpstra, Maria E. N. van den Heuvel, Maria G. Van Pampus, Odile A. van den Heuvel and Birit F. P. Broekman
    Citation: International Journal of Bipolar Disorders 2023 11:24
  36. Evidence regarding the rate of relapse in people with bipolar disorder (BD), particularly from the UK, is lacking. This study aimed to evaluate the rate and associations of clinician-defined relapse over 5 yea...

    Authors: Danielle Hett, Isabel Morales-Muñoz, Buse Beril Durdurak, Max Carlish and Steven Marwaha
    Citation: International Journal of Bipolar Disorders 2023 11:23
  37. Sunlight contains ultraviolet B (UVB) radiation that triggers the production of vitamin D by skin. Vitamin D has widespread effects on brain function in both developing and adult brains. However, many people l...

    Authors: Michael Bauer, Tasha Glenn, Eric D. Achtyes, Martin Alda, Esen Agaoglu, Kürsat Altınbaş, Ole A. Andreassen, Elias Angelopoulos, Raffaella Ardau, Memduha Aydin, Yavuz Ayhan, Christopher Baethge, Rita Bauer, Bernhard T. Baune, Ceylan Balaban, Claudia Becerra-Palars…
    Citation: International Journal of Bipolar Disorders 2023 11:22
  38. Rapid-cycling (RC; ≥ 4 episodes/year) in bipolar disorder (BD) has been recognized since the 1970s and associated with inferior treatment response. However, associations of single years of RC with overall cycl...

    Authors: Alessandro Miola, Leonardo Tondo, Marco Pinna, Martina Contu and Ross J. Baldessarini
    Citation: International Journal of Bipolar Disorders 2023 11:21
  39. Lithium has long been considered the gold-standard pharmacological treatment for the maintenance treatment of bipolar disorders (BD) which is supported by a wide body of evidence. Prior research has shown a st...

    Authors: Diego Hidalgo-Mazzei, Tim Mantingh, Xavier Pérez de Mendiola, Ludovic Samalin, Juan Undurraga, Sergio Strejilevich, Emanuel Severus, Michael Bauer, Ana González-Pinto, Willem A. Nolen, Allan H. Young and Eduard Vieta
    Citation: International Journal of Bipolar Disorders 2023 11:20
  40. Detecting prodromal symptoms of bipolar disorder (BD) has garnered significant attention in recent research, as early intervention could potentially improve therapeutic efficacy and improve patient outcomes. T...

    Authors: Yijun Shao, Yan Cheng, Srikanth Gottipati and Qing Zeng-Treitler
    Citation: International Journal of Bipolar Disorders 2023 11:19
  41. Several studies have reported on the feasibility of electronic (e-)monitoring using computers or smartphones in patients with mental disorders, including bipolar disorder (BD). While studies on e-monitoring ha...

    Authors: Abigail Ortiz, Yunkyung Park, Christina Gonzalez-Torres, Martin Alda, Daniel M. Blumberger, Rachael Burnett, M. Ishrat Husain, Marcos Sanches and Benoit H. Mulsant
    Citation: International Journal of Bipolar Disorders 2023 11:18
  42. Response to lithium (Li) is highly variable in bipolar disorders (BD). Despite decades of research, no clinical predictor(s) of response to Li prophylaxis have been consistently identified. Recently, we develo...

    Authors: C. Marie-Claire, C. Courtin, F. Bellivier, S. Gard, M. Leboyer, J. Scott and B. Etain
    Citation: International Journal of Bipolar Disorders 2023 11:16