Evaluating depressive symptoms in hypomanic and manic episodes using a structured diagnostic tool: validation of a new Mini International Neuropsychiatric Interview (M.I.N.I.) module for the DSM-5 'With Mixed Features’ specifier

International Journal of Bipolar Disorders

Table 2 Validation of the M.I.N.I. module to identify individual depressive symptoms (Phase II)

Symptom	Sensitivity	Specificity	PPV	NPV	κ
Depressed mood	0.87	0.73	0.79	0.82	0.60
Diminished interest/pleasure	0.87	0.63	0.69	0.84	0.50
Psychomotor retardation	0.63	0.82	0.50	0.89	0.42
Fatigue/loss of energy	0.81	0.69	0.70	0.80	0.50
Worthless/guilty feelings	0.76	0.77	0.66	0.85	0.51
Suicidal thoughts	0.90	0.90	0.72	0.97	0.74

Proportions of patients experiencing each depressive symptom during a manic episode, as reported by patients using the M.I.N.I. module compared with those reported by psychiatrists using DSM-5 criteria during clinical interviewing. κ, Cohen’s kappa coefficient; NPV, negative predictive value; PPV, positive predictive value.