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Table 3 Analysis of genotype differences in relation to kidney function

From: The association of glycogen synthase kinase-3beta (GSK-3β) gene polymorphism with kidney function in long-term lithium-treated bipolar patients

  T/T T/C C/C T/T vs. T/C vs. C/C T/T vs. T/C + C/C T/T + T/C vs. C/C
  N= 34 N= 37 N= 7 (ANOVA) t test t test
Urine specific gravity 1,012 ± 0.007 1,013 ± 0.007 1,019 ± 0.008 p = 0.052 p = 0.215 p = 0.035
Serum creatinine, total (mg/dl) 0.89 ± 0.20 0.99 ± 0.28 0.98 ± 0.23 p = 0.448 p = 0.074 p = 0.603
Male 1.19 ± 0.25 1.16 ± 0.32 1.22 ± 0.10 p = 0.939 p = 0.884 p = 0.781
N = 6 N = 16 N = 3
Female 0.83 ± 0.12 0.85 ± 0.14 0.80 ± 0.06 p = 0.774 p = 0.772 p = 0.515
N = 28 N = 21 N = 4
Estimated glomerular filtration rate (ml/min/1.73 m2) 71 ± 13 71 ± 16 68 ± 9 p = 0.977 p = 1.000 p = 0.606
Serum neutrophil gelatinase-associated lipocalin (ng/ml) 288 ± 89 321 ± 142 248 ± 81 p = 0.441 p = 0436 p = 0.216
Urine beta2-microglobulin (μg/ml) 0.22 ± 0.24 0.16 ± 0.14 0.13 ± 0.05 p = 0.279 p = 0.162 p = 0.410
  1. The p values of the differences in kidney function values are expressed as means ± SD. Italicized p value indicates urine specific gravity significantly higher in C/C patients compared to remaining genotypes combined.