Figure 4

The impact of mania induction on total locomotor activity and rest intervals during light and dark phases. A significant increase in the total activity counts during the light phase (A) during mania induction compared with the baseline interval. Interaction (P < 0.006) in the LHK (*P < 0.001), and NAC (*P < 0.01), but not in the LHT-sham (P > 0.05), or ILC groups (P > 0.05). Similarly, increased activity during the dark phase (B) was evident. Interaction (P = 0.02) in the LHK (*P < 0.001), NAC (*P < 0.05), and ILC (*P < 0.05), but not in the LHT-sham (P > 0.05). Total rest interval during light phase (C) shows a significant decrease with interaction (P = 0.009) during mania induction compared with the baseline interval in all groups, the LHK (*P < 0.001), NAC (*P < 0.001), ILC (*P < 0.01), and in the LHT-sham (*P < 0.05). Total rest interval during dark phase (D) shows no significant decrease in total duration of rest during mania induction compared with the baseline interval in the LHK (P > 0.05), NAC (P > 0.05), or LHT-sham (P > 0.05) but and a significant increase in the ILC (P < 0.05) with an interaction (P = 0.0005) by two-way ANOVA; *P < 0.05 by post hoc test; n = 8 to 12 per group. Data is expressed as mean ± SEM.