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Table 3 Summary of findings for the FEM acute studies

From: Cognitive impairment in first-episode mania: a systematic review of the evidence in the acute and remission phases of the illness

Cognitive function

Controls

FEM

Statistics

Study

Domain

Test

Specific

n

Mean (SD)

n

Mean (SD)

p value

Effect size

First author (year)

Executive function

Wisconsin Card Sorting Test

Perseverative errors (%)

48

12.4 (10.7)

21

19.2 (12.2)

0.01a,b

0.59e

Fleck et al. (2008)

Perseverative responses (n)

48

14.8 (18.9)

21

28.3 (22.6)

0.01a,b

0.65e

Non-perseverative errors (n)

48

13.1 (14.8)

21

19.5 (13.8)

0.001a,b

0.43e

Unique errors (n)

48

1.8 (5.3)

21

4.9 (8.6)

0.001a,b

0.47e

Failure to maintain set (n)

48

0.6 (0.9)

21

0.5 (1.0)

0.32a

0.13e

Stop signal design

Targets, correct (%)

16

50 (12)

16

44 (20)

0.13c

NR

Strakowski et al. (2008)

Stops, correct (%)

16

89 (9)

16

91 (7)

0.25c

NR

Discriminability

16

0.85 (0.04)

16

0.87 (0.06)

0.27c

NR

Bias

16

0.14 (0.03)

16

0.11 (0.05)

0.17c

NR

Target, RT (ms)

16

580 (10)

16

575 (36)

0.57c

NR

Controlled Oral Word Association Test

FAS

30

39.57 (11.07)

19

38.52 (10.95)

>0.05d

NR

Lebowitz et al. (2001)

Animal category

30

19.71 (3.69)

19

18.43 (3.63)

>0.05d

NR

  1. n, number; RT, reaction time; ms, milliseconds; NR, not reported. aKruskal-Wallis and Chi-square tests; bsignificant difference between groups after Mann-Whitney U test for pairwise comparisons; cone-sample t-tests; done-way or univariate analysis of variance; eCohenā€™s d.