Long-term lithium treatment in bipolar disorder: effects on glomerular filtration rate and other metabolic parameters

International Journal of Bipolar Disorders

Table 2 Subject age and lithium exposure across study sites

Study site	Subjects (n)	Intake age^a	Final age^b	Years on Li^c
Barcelona: University of Barcelona	26	32.3 ± 8.06	51.8 ± 11.4	19.4 ± 7.41
Berlin: Charité Medical Center	30	39.5 ± 12.4	56.6 ± 14.9	17.2 ± 8.12
Buenos Aires: Palermo University	9	47.2 ± 12.0	62.3 ± 13.4	15.1 ± 5.93
Cagliari: Lucio Bini Mood Disorder Center	50	38.1 ± 12.1	54.6 ± 14.5	17.5 ± 8.61
Cagliari: University of Cagliari	30	37.1 ± 11.2	62.2 ± 13.1	24.1 ± 8.86
Dresden: University of Dresden	22	33.5 ± 12.7	53.8 ± 13.2	20.3 ± 9.49
Halifax: Dalhousie University	27	43.5 ± 13.7	55.4 ± 13.7	11.9 ± 3.97
Lugano: Viarnetto Clinic	21	33.8 ± 11.6	52.0 ± 12.9	18.2 ± 9.45
Pisa: University of Pisa	25	37.6 ± 13.1	49.4 ± 13.8	11.7 ± 6.29
Poznan: University of Poznan	20	43.1 ± 14.2	66.2 ± 10.7	23.1 ± 8.59
Rome: Lucio Bini Mood Disorder Center	46	36.8 ± 15.6	54.6 ± 15.9	18.4 ± 9.47
Würzburg: University of Würzburg	6	45.0 ± 14.9	61.8 ± 9.75	6.80 ± 7.94
Total [95% CI]	312	37.9 [37.5–39.3]	55.8 [54.2–57.4]	17.9 [16.9–18.9]

Total exposure = 6142 person-years
Across the 12 sites, among 312 subjects: ^a t = 1.55, p = 0.007; ^b t = 1.70, p = 0.001; ^c t = 1.13, p = 0.24