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International Journal of Bipolar Disorders

Table 6 Rate of decrease of eGFR with age and lithium exposure (%/year)

From: Long-term lithium treatment in bipolar disorder: effects on glomerular filtration rate and other metabolic parameters

Group

eGFR decrease, %/year [95% CI] (n)

Age: healthy adults

Age: lithium-treated

Years of lithium

All subjects

0.637 [0.497–0.777] (365)

0.710 [0.653–0.767] (312)

0.915 [0.822–1.08] (312)

Men

0.488 [0.361–0.616] (160)

0.631 [0.545–0.717] (132)

0.785 [0.546–0.717] (132)

Women

0.754 [0.580–0.928] (205)

0.756 [0.682–0.829] (180)

0.934 [0.815–1.05] (180)

  1. Lithium-treated subjects are from the present study. Data for healthy adults are adapted from Rule et al. (2004) for clearance of iothalamate. Rates of GFR decrease as %/year are computed as [initial eGFR − observed eGFR]/[initial eGFR] × 100 with 95% confidence intervals and number (n) of subjects (eGFR is in units of mL/min/1.73 m2)
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