Fig. 2

Incidence of baseline AIA symptoms in BD-I mania, stratified by the number/severity of depressive symptoms. **p < 0.01,
***p < 0.001, Chi squared test. Anxiety was defined as a PANSS anxiety item score of ≥3 at baseline. Irritability was defined as a YMRS irritability item score of ≥4 at baseline. Agitation was defined as a YMRS increased motor activity–energy item score of ≥3 at baseline. Severe AIA was defined as meeting the above criteria for all three AIA symptoms. Patients missing a value for the corresponding symptom at baseline were not included in the analysis. ^a Based on the number of individual MADRS items with a score of ≥1. AIA, anxiety, irritability, and agitation; BD-I, bipolar I disorder; MADRS, Montgomery–Åsberg Depression Rating Scale; PANSS, Positive and Negative Syndrome Scale; YMRS, Young Mania Rating Scale. a Number of depressive symptoms of 0-2 symptoms versus 3 or more symptoms, and b severity of depressive symptoms baseline MADRS <20 versus ≥ to 20