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Table 4 Associations between cofactors and chronobiological variables

From: The association between mood state and chronobiological characteristics in bipolar I disorder: a naturalistic, variable cluster analysis-based study

  IS
RC
(p value)
RA
RC
(p value)
GOF
RC
(p value)
CQ
RC
(p value)
24-h correlation
RC
(p value)
SRM-5
RC
(p value)
PSQI
RC
(p value)
Medications
 Li 0.07 (0.054)a 0.06 (0.082)a 0.07 (0.037)* 0.04 (0.377) 0.07 (0.023)* 0.11 (0.725) 1.57 (0.127)
 AC − 0.03 (0.20) − 0.03 (0.255) − 0.02 (0.335) 0.008 (0.806) − 0.03 (0.228) − 0.06 (0.813) − 0.18 (0.821)
 AD − 0.05 (0.078)a − 0.07 (0.004)* − 0.05 (0.031)* − 0.04 (0.178) − 0.05 (0.03)* − 0.39 (0.128) 1.46 (0.07)a
 AP 0.00 (0.974) 0.02 (0.322) − 0.02 (0.355) − 0.03 (0.322) − 0.03 (0.168) 0.05 (0.859) − 0.37 (0.646)
 BZD − 0.03 (0.378) − 0.03 (0.295) − 0.01 (0.691) − 0.01 (0.766) − 0.01 (0.751) − 0.42 (0.15) 1.24 (0.176)
Other covariates
 Age 0.0004 (0.75) − 0.001 (0.198) − 0.0003 (0.769) − 0.0002 (0.86) − 0.001 (0.272) 0.014 (0.19) 0.042 (0.235)
 Gender (female) 0.074 (0.015)* 0.052 (0.062)a 0.072 (0.004)* 0.09 (0.007)* 0.054 (0.034)* 0.172 (0.517) 0.23 (0.779)
  1. The table highlights the associations between cofactors and chronobiological variables identified via cluster analysis. Results are presented as regression coefficients (RC) and associated p values
  2. Li lithium, AC anticonvulsants, AD antidepressants, AP antipsychotics, BZD benzodiazepines. IS interdaily stability, IV intradaily variability, RA relative amplitude, CQ circadian quotient, GOF goodness-of-fit, SRM-5 5-Item Social Rhythm Metric, PSQI Pittsburgh Sleep Quality Index
  3. * and italic font denotes statistical significance
  4. aDenotes a trend toward significance