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Table 4 Associations between cofactors and chronobiological variables

From: The association between mood state and chronobiological characteristics in bipolar I disorder: a naturalistic, variable cluster analysis-based study

 

IS

RC

(p value)

RA

RC

(p value)

GOF

RC

(p value)

CQ

RC

(p value)

24-h correlation

RC

(p value)

SRM-5

RC

(p value)

PSQI

RC

(p value)

Medications

 Li

0.07 (0.054)a

0.06 (0.082)a

0.07 (0.037)*

0.04 (0.377)

0.07 (0.023)*

0.11 (0.725)

1.57 (0.127)

 AC

− 0.03 (0.20)

− 0.03 (0.255)

− 0.02 (0.335)

0.008 (0.806)

− 0.03 (0.228)

− 0.06 (0.813)

− 0.18 (0.821)

 AD

− 0.05 (0.078)a

− 0.07 (0.004)*

− 0.05 (0.031)*

− 0.04 (0.178)

− 0.05 (0.03)*

− 0.39 (0.128)

1.46 (0.07)a

 AP

0.00 (0.974)

0.02 (0.322)

− 0.02 (0.355)

− 0.03 (0.322)

− 0.03 (0.168)

0.05 (0.859)

− 0.37 (0.646)

 BZD

− 0.03 (0.378)

− 0.03 (0.295)

− 0.01 (0.691)

− 0.01 (0.766)

− 0.01 (0.751)

− 0.42 (0.15)

1.24 (0.176)

Other covariates

 Age

0.0004 (0.75)

− 0.001 (0.198)

− 0.0003 (0.769)

− 0.0002 (0.86)

− 0.001 (0.272)

0.014 (0.19)

0.042 (0.235)

 Gender (female)

0.074 (0.015)*

0.052 (0.062)a

0.072 (0.004)*

0.09 (0.007)*

0.054 (0.034)*

0.172 (0.517)

0.23 (0.779)

  1. The table highlights the associations between cofactors and chronobiological variables identified via cluster analysis. Results are presented as regression coefficients (RC) and associated p values
  2. Li lithium, AC anticonvulsants, AD antidepressants, AP antipsychotics, BZD benzodiazepines. IS interdaily stability, IV intradaily variability, RA relative amplitude, CQ circadian quotient, GOF goodness-of-fit, SRM-5 5-Item Social Rhythm Metric, PSQI Pittsburgh Sleep Quality Index
  3. * and italic font denotes statistical significance
  4. aDenotes a trend toward significance