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Table 3 Rescue medication use during the AOM 400 maintenance phase

From: Aripiprazole once-monthly as maintenance treatment for bipolar I disorder: a 52-week, multicenter, open-label study

Medication Enrollment source Number of patients Number (%) taking rescue medication Duration (days)a
Mean SD Median
Lithium De novo 379 28 (7.4) 147.9 101.8 131.5
Rollover 85 0
Total 464 28 (6.0) 147.9 101.8 131.5
Valproate De novo 379 35 (9.2) 114.5 96.6 100
Rollover 85 1 (1.2) 84.0 84.0
Total 464 36 (7.8) 113.7 95.4 92.0
  1. Rescue medication (lithium [immediate or controlled release] or valproate [immediate or extended release]) was recommended for patients not meeting stability criteria. Only one type of rescue medication was permitted at a time. Patients meeting stability criteria were not eligible for rescue medication
  2. AOM 400 aripiprazole once-monthly 400 mg, SD standard deviation
  3. aCalculated for patients receiving AOM 400 during maintenance phase who took rescue medication during maintenance phase