Table 1 Obstetric outcome after lithium treatment during pregnancy: findings from clinical cohort studies
Study | Design | Sample size | Findings |
|---|---|---|---|
Petersen et al. (2016) | Registry-based study | Exposed = 35 Disease matched non-exposed = 84 Controls = 320.853 | No difference in the rate of caesarean sections |
Frayne et al. (2017) | Cohort study | Exposed = 33 | No difference in the rate of obstetric complications between the women that continued (n = 19) or discontinued (n = 14) lithium |
Munk-Olsen et al. (2018) | Meta-analysis (six study sites) | Exposed = 727 Disease matched controls = 21,397 | No association between lithium exposure in utero and preeclampsia (OR 0.97, 95% CI 0.52–1.80), gestational diabetes (OR 1.20, 95% CI 0.81–1.78), fetal distress (OR 1.00, 95% CI 0.76–1.32), postpartum hemorrhage (OR 1.28, 95% CI 0.64–2.57) and caesarean section (OR 0.94, 95% CI 0.66–1.33) |