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Table 2 Effect of genes and environmental factors on lymphoid subsets in relation of bipolar disorder

From: Genetic and environmental influences on circulating NK and T cells and their relation to bipolar disorder

Cell population A. Sources on variance on lymphoid subsets, irrespective of disease (n = 106), % (95% CI) Phenotypic correlation
h2 c2 e2 Rph p
T helper 17 cells 0.79 (0.35–0.88) 0.009 (NA–0.37) 0.21 (0.11–0.38) 0.02 (− 0.17–0.22) 0.80
T regulator cells 0.69 (0.17–0.85) 0.029 (NA–0.39) 0.28 (0.14–0.55) 0.06 (− 0.13–0.25) 0.53
Total T helper cells 0.59 (0.04–0.87) 0.18 (0.00–0.63) 0.22 (0.12–0.42) − 0.06 (−0.25–0.13) 0.54
Total T cells 0.57 (0.00–0.82) 0.11 (0.00–0.57) 0.32 (0.18–0.59) − 0.21 (− 0.38–0.02) 0.03*
T helper 2 cells 0.51 (0.01–0.86) 0.27 (0.00–0.67) 0.22 (0.11–0.47) 0.10 (− 0.09–0.28) 0.30
NK cells 0.50 (0.00–0.82) 0.21 (0.00–0.62) 0.28 (0.14–0.54) 0.18 (0.00–0.34) 0.04*
Monocytes 0.25 (0.09–0.43) 0.30 (0.11–0.51) 0.45 (0.28–0.69) 0.15 (− 0.03–0.32) 0.10
T helper 1 cells 0.19 (0.00–0.74) 0.38 (0.00–0.69) 0.43 (0.24-0.69) − 0.05 (− 0.23–0.13) 0.57
Cell population B. Bipolar twins and their co-twins (n = 52) Healthy control twins (n = 54)    
M (S.E.)a M (S.E)a P (MANCOVA/ANCOVAb)
T helper 17 cells 0.29 (1.07) 0.27 (1.07) 0.349    
T regulator cells 1.92 (1.04) 1.83 (1.04) 0.698    
Total T helper cells 38.05 (1.18) 38.37 (1.18) 0.402    
Total T cells 54.48 (1.18) 59.0 (1.17) 0.015/0.007*    
T helper 2 cells 0.68 (1.06) 0.62 (1.6) 0.457    
NK cells 12.62 (0.66) 10.01 (0.63) 0.009/0.006*    
Monocytes 18.53 (0.81) 16.86 (0.81) 0.181    
T helper 1 cells 5.47 (1.07) 5.97 (1.06) 0.553    
  1. The different lymphoid subsets and NK cells are displayed in order of highest to lowest source of genetic variance
  2. T helper 17 cells: CD4+ IL17A. T regulatory cells: CD3+ CD25 highFoxP3+. Total T helper cells: CD3+ CD4+ CD8−;Total T-cells: CD3+; T helper 2 cells: CD4+ IL-4+; NK cells: CD3+–CD56+; Monocytes: CD14+, T helper 1 cells: CD4+ IFN-y+
  3. Monocytes, T cells, T helper cells and NK cells were expressed in the calculations as percentages of intact CD45+ PBMC
  4. The subsets of T helper cells (T helper 17, T helper 2, T helper 1 and T regulator cells) were expressed in the calculations as percentages of lymphocytes
  5. * Significant at p = 0.05, uncorrected for multiple comparisons
  6. aTo normalize data some values were transformed, for interpretation the means and standard errors were back transformed
  7. bp value based on multivariate analysis (MANOVA). A follow-up univariate analysis with post hoc least significance difference (LSD) analysis was performed for NK cells and total T cells