Fig. 1
From: Alterations of perineuronal nets in the dorsolateral prefrontal cortex of neuropsychiatric patients
Alterations of PV and PNN densities in neuropsychiatric disorders. a Panoramic confocal microphotograph showing WFA-labeled PNNs (blue) surrounding PV positive somata (red) in the deep layers of the dorsolateral prefrontal cortex (DLPFC) of a control individual. b Images of single confocal planes showing PNNs surrounding PV+ somata in the DLPFC in patients suffering from major depression (MD), bipolar disorder (BD) and schizophrenia (SCHZ) and controls (NOR). White arrowheads point to PV+ somata surrounded by PNNs, yellow arrowheads point to PV+ cells lacking PNNs and white arrows point to PNNs surrounding PV− somata. c–g Histograms showing the density of PV expressing interneurons (c), PNNs (d) and the percentages of PV expressing somata surrounded by PNNs (e), of PNNs surrounding PV+ somata (f) and of PNNs not surrounding PV+ somata (g). There are significant differences in the density of PNN between control individuals and bipolar patients (*p = 0.012). Scale bar: 20 µm