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Table 4 Correlation between TNF-α, CRP, and BDNF with clinical symptoms and metabolic parameters

From: Combination of dextromethorphan and memantine in treating bipolar spectrum disorder: a 12-week double-blind randomized clinical trial

 

TNF-α

CRP

BDNF

B

Wald χ2

P-value

B

Wald χ2

P-value

B

Wald χ2

P-value

HDRS

0.45

1.07

0.30

0.22

0.62

0.43

0.11

1.94

0.16

YMRS

0.20

0.32

0.57

0.72

4.82

0.03*

− 0.01

0.30

0.58

TC

− 1.83

0.28

0.60

1.98

0.32

0.58

0.52

4.20

0.04*

HDL-C

− 5.34

6.24

0.01*

− 11.61

24.82

< 0.001**

0.02

0.02

0.89

LDL-C

− 1.91

0.41

0.53

5.51

3.19

0.07

0.38

2.69

0.10

Triglycerides

22.78

10.67

0.001**

34.58

22.38

< 0.001**

0.97

3.46

0.06

FBS

− 6.37

1.30

0.26

0.73

0.13

0.72

0.27

3.41

0.07

  1. TNF-α tumor necrosis factor α, CRP C-reactive protein, BDNF brain-derived neurotrophic factor, B standardized coefficient, HDRS 17-item Hamilton Depression Rating Scale, YMRS Young Mania Rating Scale, TC total cholesterol, HDL-C high-density lipoprotein-cholesterol, LDL-C low-density lipoprotein-cholesterol, FBS fasting blood sugar
  2. *P < 0.05; **P < 0.01