The role of environmental stress and DNA methylation in the longitudinal course of bipolar disorder

International Journal of Bipolar Disorders

Table 2 Top 20 CpG sites associated with total LEQ scores

Probe	t value	p-value	FDR-corrected p-value	Chr	Relation to island	Annotated gene
cg15212455	− 4.87	3.56E−06	0.263	chr7	Open Sea	POU6F2
cg05335886	− 4.55	1.02E−05	0.263	chr16	Island	TMC5
cg09725915	4.54	1.05E−05	0.263	chr2	Island
cg24511004	4.43	1.62E−05	0.263	chr1	Open Sea
cg18110277	− 4.50	1.74E−05	0.263	chr2	Open Sea
cg21516302	− 4.24	4.58E−05	0.575	chr2	Open Sea
cg05180443	− 4.04	8.61E−05	0.927	chr17	Island	CHAD; ACSF2
cg01440452	− 3.97	1.03E−04	0.946	chr5	N Shore	PURA
cg26730347	− 4.00	1.20E−04	0.946	chr22	N Shore	SLC5A1
cg15869582	3.94	1.26E−04	0.946	chr6	S Shore	IBTK
cg05919744	3.95	1.44E−04	0.977	chr11	S Shore	SLC22A18AS;SLC22A18
cg26822318	3.86	1.61E−04	0.977	chr8	Open Sea	FER1L6
cg27296293	− 3.80	1.98E−04	0.977	chr11	Island	RP11-748H22.1; TRPC6
cg06334363	3.82	2.01E−04	0.977	chr9	S Shore	RP11-235C23.5; FKTN
cg00356897	− 3.79	2.30E−04	0.977	chr1	Open Sea	RP4-594I10.2
cg24795825	3.72	2.98E−04	0.977	chr15	N Shore	MORF4L1
cg17984201	3.69	3.17E−04	0.977	chr13	Open Sea
cg18002447	− 3.67	3.20E−04	0.977	chr17	Island
cg07349208	− 3.66	3.36E−04	0.977	chr4	Island	RP11-380D23.2
cg05705044	3.65	3.38E−04	0.977	chr11	S Shore	RBM7