The role of environmental stress and DNA methylation in the longitudinal course of bipolar disorder

International Journal of Bipolar Disorders

Table 3 Blood-brain methylation correlation for top differentially methylated CpGs associated with total LEQ scores

Probe	Blood-PFC	p-value	Blood-EC	p-value	Blood-STG	p-value	Blood-CER	p-value
cg15212455	0.721	4.16E−13	0.731	4.64E−13	0.747	1.48E−14	0.631	3.71E−09
cg05335886	− 0.086	0.467	− 0.101	0.404	− 0.145	0.213	− 0.155	0.196
cg09725915	0.576	7.86E−08	0.532	1.76E−06	0.626	1.96E−09	0.489	1.49E−05
cg21516302	0.373	0.001	0.522	3.01E−06	0.507	3.46E−06	0.307	0.009
cg05180443	0.204	0.081	0.336	0.004	0.298	0.009	0.175	0.144
cg01440452	− 0.097	0.413	0.062	0.606	− 0.119	0.309	0.020	0.870
cg26730347	0.499	6.05E−06	0.568	2.33E−07	0.562	1.51E−07	0.493	1.27E−05
cg27296293	0.131	0.265	− 0.214	0.073	0.037	0.755	0.236	0.048
cg24795825	0.016	0.894	0.299	0.011	0.247	0.033	0.121	0.317
cg18002447	0.038	0.749	0.034	0.776	0.042	0.720	− 0.262	0.028
cg07349208	0.167	0.156	0.095	0.431	− 0.112	0.338	0.068	0.571

PFC prefrontal cortex, EC entorhinal cortex, STG superior temporal gyrus, CER cerebellum
Significant correlations in italics