Table 1 Percent observed or mean of all variables included as covariates in the models and 95% confidence intervals for the percent or mean, for full sample (n = 292) and individuals with the outcome (n = 112)

Time-fixed

 Sex (male)

121 (41.4)

[35.8, 47.1]

35 (31.3)

[22.6, 39.9]

 Age (at outcome or censoring)

21.0

[20.2, 21.9]

19.6

[18.6, 20.6]

 Parental lithium response

129 (44.2)

[38.5, 49.9]

47 (42.0)

[32.8, 51.1]

 Parental onset age

25.4

[24.4, 26.5]

25.5

[23.7, 27.4]

 Physical/sexual abuse

  Yes

30 (10.3)

[6.1, 13.8]

14 (12.5)

[6.3, 18.7]

  Missing^a

111 (38.0)

[32.4, 43.6]

32 (28.6)

[20.2, 37.0]

Time-Varying

Disorders

 Subthreshold^b activation

29 (9.9)

[6.5, 13.4]

19 (17.0)

[10.0, 23.9]

 Subthreshold depression

31 (10.6)

[7.1, 14.2]

17 (15.2)

[8.5, 21.6]

 Subthreshold sleep

9 (3.1)

[1.1, 5.1]

2 (1.8)

[0.0, 4.2]

 Subthreshold substance use

36 (12.3)

[8.6, 16.1]

13 (11.6)

[5.6, 17.6]

 Subthreshold anxiety

45 (15.4)

[11.3, 19.6]

17 (15.2)

[8.5, 21.9]

 Substance use

51 (17.5)

[13.1, 21.8]

29 (25.9)

[17.7, 34.0]

 Sleep

54 (18.5)

[14.0, 23.0]

18 (16.1)

[9.2, 22.9]

 Anxiety

87 (29.8)

[24.5, 35.0]

39 (34.8)

[26.0, 43.7]

 Neurodevelopmental

33 (11.3)

[7.7, 14.9]

12 (10.7)

[5.0, 16.5]

Number of episodes

 Major mood

0.2

[0.1, 0.3]

0.2

0.1, 0.3]

 Minor mood

0.2

[0.1, 0.3]

0.1

[0.0, 0.2]