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Table 3 Body weight and laboratory parameters: mean (SD) change from long-term baseline to week 52 (observed case analysis)

From: Lurasidone in the long-term treatment of Japanese patients with bipolar I disorder: a 52 week open label study

Parameter Most recent or current episode of bipolar I disorder
All Depressed episode Non-Depressed episode
Body Weight, kg
  Mean change
  Median change
n = 99
0.0 (5.6)
0.1
n = 52
− 0.8 (5.6)
0.1
n = 47
(5.5)
0.1
Triglycerides (mmol/L) -fasting
  Mean change
  Median change
n = 99
0.061 (0.667)
0.068
n = 52
0.113 (0.734)
0.073
n = 47
0.003 (0.587)
0.057
Total cholesterol (mmol/L) -fasting
  Mean change
  Median change
n = 99
− 0.080 (0.656)
− 0.026
n = 52
− 0.065 (0.695)
− 0.091
n = 47
− 0.098 (0.617)
0.052
LDL cholesterol (mmol/L) -fasting
  Mean change
  Median change
n = 97
− 0.039 (0.545)
0.026
n = 50
− 0.064 (0.603)
0.039
n = 47
− 0.012 (0.482)
0.026
HDL cholesterol (mmol/L) -fasting
  Mean change
  Median change
n = 99
− 0.047 (0.276)
− 0.052
n = 52
− 0.018 (0.255)
− 0.039
n = 47
− 0.079 (0.297)
− 0.052
Blood Glucose (mmol/L) -fasting
  Mean change
  Median change
n = 99
0.044 (0.606)
0.111
n = 52
0.045 (0.690)
0.111
n = 47
0.044 (0.504)
0.056
Insulin (pmol/L) -fasting n = 98
9.68 (63.54)
9.72
n = 51
8.42 (76.05)
9.03
n = 47
11.05 (47.14)
10.42
HOMA-IR -fasting
  Mean change
  Median change
n = 98
0.37 (2.76)
0.33
n = 51
0.34 (3.46)
0.30
n = 47
0.40 (1.73)
0.35
Hemoglobin A1C (%)
  Mean change
  Median change
n = 99
0.00 (0.29)
0.00
n = 52
− 0.01 (0.35)
0.00
n = 47
0.01 (0.20)
0.00
Prolactin, (μg/L), Overall
  Mean change
  Median change
n = 98
− 1.7 (17.6)
− 0.5
n = 51
− 5.5 (18.7)
− 1.3
n = 47
2.3 (15.5)
1.3
Prolactin, (μg/L), Male
  Mean change
  Median change
n = 44
− 0.3 (9.2)
− 0.3
n = 24
0.3 (7.5)
− 0.5
n = 20
− 0.9 (11.1)
0.3
Prolactin, (μg/L), Female
  Mean change
  Median change
n = 54
− 3.0 (22.2)
− 0.6
n = 27
− 10.6 (23.8)
− 2.6
n = 27
4.7 (17.9)
3.7