Table 3 Body weight and laboratory parameters: mean (SD) change from long-term baseline to week 52 (observed case analysis)
Parameter | Most recent or current episode of bipolar I disorder | ||
|---|---|---|---|
All | Depressed episode | Non-Depressed episode | |
Body Weight, kg Mean change Median change | n = 99 0.0 (5.6) 0.1 | n = 52 − 0.8 (5.6) 0.1 | n = 47 (5.5) 0.1 |
Triglycerides (mmol/L) -fasting Mean change Median change | n = 99 0.061 (0.667) 0.068 | n = 52 0.113 (0.734) 0.073 | n = 47 0.003 (0.587) 0.057 |
Total cholesterol (mmol/L) -fasting Mean change Median change | n = 99 − 0.080 (0.656) − 0.026 | n = 52 − 0.065 (0.695) − 0.091 | n = 47 − 0.098 (0.617) 0.052 |
LDL cholesterol (mmol/L) -fasting Mean change Median change | n = 97 − 0.039 (0.545) 0.026 | n = 50 − 0.064 (0.603) 0.039 | n = 47 − 0.012 (0.482) 0.026 |
HDL cholesterol (mmol/L) -fasting Mean change Median change | n = 99 − 0.047 (0.276) − 0.052 | n = 52 − 0.018 (0.255) − 0.039 | n = 47 − 0.079 (0.297) − 0.052 |
Blood Glucose (mmol/L) -fasting Mean change Median change | n = 99 0.044 (0.606) 0.111 | n = 52 0.045 (0.690) 0.111 | n = 47 0.044 (0.504) 0.056 |
Insulin (pmol/L) -fasting | n = 98 9.68 (63.54) 9.72 | n = 51 8.42 (76.05) 9.03 | n = 47 11.05 (47.14) 10.42 |
HOMA-IR -fasting Mean change Median change | n = 98 0.37 (2.76) 0.33 | n = 51 0.34 (3.46) 0.30 | n = 47 0.40 (1.73) 0.35 |
Hemoglobin A1C (%) Mean change Median change | n = 99 0.00 (0.29) 0.00 | n = 52 − 0.01 (0.35) 0.00 | n = 47 0.01 (0.20) 0.00 |
Prolactin, (μg/L), Overall Mean change Median change | n = 98 − 1.7 (17.6) − 0.5 | n = 51 − 5.5 (18.7) − 1.3 | n = 47 2.3 (15.5) 1.3 |
Prolactin, (μg/L), Male Mean change Median change | n = 44 − 0.3 (9.2) − 0.3 | n = 24 0.3 (7.5) − 0.5 | n = 20 − 0.9 (11.1) 0.3 |
Prolactin, (μg/L), Female Mean change Median change | n = 54 − 3.0 (22.2) − 0.6 | n = 27 − 10.6 (23.8) − 2.6 | n = 27 4.7 (17.9) 3.7 |