Table 1 Demographic and clinical variables
ITT | PP | |||||||
|---|---|---|---|---|---|---|---|---|
Sham | Treatment | t/chi2 | p | Sham | Treatment | t/chi2 | p | |
n = 28 | n = 26 | n = 25 | n = 23 | |||||
Age, mean (SD) | 39.4 (11.3) | 40.7 (11.4) | − 0.4 | 0.69 | 40.0 (11.4) | 39.7 (11.6) | 0.09 | 0.93 |
Sex, male n (%) | 10 (36) | 8 (31) | 0.01 | 0.92 | 9 (36) | 8 (35) | 0.05 | 0.83 |
Education, n (%) | – | 0.70 | – | 0.5 | ||||
Primary or below | 1 (4) | 1 (4) | 1 (4) | 1 (4) | ||||
Secondary | 12 (43) | 8 (31) | 12 (48) | 7 (30) | ||||
Post-secondary | 15 (54) | 17 (65) | 12 (48) | 15 (65) | ||||
Bipolar disorder subtype, n (%) | – | 1 | – | 1 | ||||
Type 1 | 4 (14) | 4(15) | 4 (16) | 4 (17) | ||||
Type 2 | 24 (86) | 22 (85) | 21 (84) | 19 (83) | ||||
Baseline MADRS, mean (SD) | 27.0 (5.1) | 27.5 (5.2) | − 0.41 | 0.68 | 26.2 (3.8) | 26.8 (4.9) | − 0.48 | 0.63 |
Baseline HAM-A, mean (SD) | 20.5 (7.0) | 21.0 (10.3) | − 0.19 | 0.85 | 21.0 (7.1) | 20.0 (10.4) | 0.38 | 0.71 |
Baseline YMRS mean (SD) | 1.0 (1.9) | 2.3 (3.2) | − 1.83 | 0.07 | 1.1 (2.0) | 1.7 (2.4) | − 0.82 | 0.42 |
Melancholic specifier, n (%) | 18 (64) | 17 (65) | 0.04 | 0.84 | 16 (64) | 14 (61) | 0.01 | 0.94 |
Atypical specifier, n (%) | 6 (21) | 13 (50) | 3.65 | 0.06 | 6 (24) | 11 (48) | 2.02 | 0.16 |
Rapid cycling specifier, n (%) | 13 (46) | 17 (65) | 1.27 | 0.26 | 12 (48) | 15 (65) | 0.83 | 0.36 |
Onset | 23.5 (8.4) | 23.9 (9.0) | − 0.18 | 0.86 | 23.7 (8.5) | 23.7 (8.8) | − 0.02 | 0.98 |
Years since onset | 15.9 (8.9) | 17.6 (9.5) | − 0.69 | 0.5 | 16.3 (8.8) | 17.0 (9.7) | − 0.23 | 0.82 |
On antidepressant at baseline, n (%) | 19 (68) | 19 (73) | 0.01 | 0.9 | 17 (68) | 17 (74) | 0.02 | 0.9 |
On antipsychotic at baseline, n (%) | 24 (86) | 20 (77) | – | 0.49 | 22 (88) | 19 (83) | 0.7 | |
Number of comorbid disorders (lifetime) | 1.9 (1.3) | 2.3 (1.2) | − 0.99 | 0.33 | 2.0 (1.3) | 2.3 (1.2) | − 0.83 | 0.41 |
(Current) | 1.5 (0.9) | 2.0 (1.1) | − 1.85 | 0.07 | 1.6 (0.9) | 2.0 (1.1) | − 1.52 | 0.14 |