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Table 1 Demographic and clinical variables

From: Antidepressant efficacy of low-frequency repetitive transcranial magnetic stimulation in antidepressant-nonresponding bipolar depression: a single-blind randomized sham-controlled trial

  ITT PP
Sham Treatment t/chi2 p Sham Treatment t/chi2 p
n = 28 n = 26 n = 25 n = 23
Age, mean (SD) 39.4 (11.3) 40.7 (11.4) − 0.4 0.69 40.0 (11.4) 39.7 (11.6) 0.09 0.93
Sex, male n (%) 10 (36) 8 (31) 0.01 0.92 9 (36) 8 (35) 0.05 0.83
Education, n (%)    0.70    0.5
 Primary or below 1 (4) 1 (4)    1 (4) 1 (4)   
 Secondary 12 (43) 8 (31)    12 (48) 7 (30)   
 Post-secondary 15 (54) 17 (65)    12 (48) 15 (65)   
Bipolar disorder subtype, n (%)    1    1
 Type 1 4 (14) 4(15)    4 (16) 4 (17)   
 Type 2 24 (86) 22 (85)    21 (84) 19 (83)   
Baseline MADRS, mean (SD) 27.0 (5.1) 27.5 (5.2) − 0.41 0.68 26.2 (3.8) 26.8 (4.9) − 0.48 0.63
Baseline HAM-A, mean (SD) 20.5 (7.0) 21.0 (10.3) − 0.19 0.85 21.0 (7.1) 20.0 (10.4) 0.38 0.71
Baseline YMRS mean (SD) 1.0 (1.9) 2.3 (3.2) − 1.83 0.07 1.1 (2.0) 1.7 (2.4) − 0.82 0.42
Melancholic specifier, n (%) 18 (64) 17 (65) 0.04 0.84 16 (64) 14 (61) 0.01 0.94
Atypical specifier, n (%) 6 (21) 13 (50) 3.65 0.06 6 (24) 11 (48) 2.02 0.16
Rapid cycling specifier, n (%) 13 (46) 17 (65) 1.27 0.26 12 (48) 15 (65) 0.83 0.36
Onset 23.5 (8.4) 23.9 (9.0) − 0.18 0.86 23.7 (8.5) 23.7 (8.8) − 0.02 0.98
Years since onset 15.9 (8.9) 17.6 (9.5) − 0.69 0.5 16.3 (8.8) 17.0 (9.7) − 0.23 0.82
On antidepressant at baseline, n (%) 19 (68) 19 (73) 0.01 0.9 17 (68) 17 (74) 0.02 0.9
On antipsychotic at baseline, n (%) 24 (86) 20 (77) 0.49 22 (88) 19 (83)   0.7
Number of comorbid disorders (lifetime) 1.9 (1.3) 2.3 (1.2) − 0.99 0.33 2.0 (1.3) 2.3 (1.2) − 0.83 0.41
(Current) 1.5 (0.9) 2.0 (1.1) − 1.85 0.07 1.6 (0.9) 2.0 (1.1) − 1.52 0.14
  1. ITT intention-to-treat, PP per-protocol, MADRS Montgomery–Åsberg Depression Rating Scale, HAMA Hamilton Anxiety Rating Scale, YMRS Young Mania Rating Scale