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Table 3 ANOVA time * group interaction effects

From: Antidepressant efficacy of low-frequency repetitive transcranial magnetic stimulation in antidepressant-nonresponding bipolar depression: a single-blind randomized sham-controlled trial

  ITT PP
F df Sig ηp2 F df Sig ηp2
ANOVA across all time points
 Multivariate
  MADRS, HAMA, YMRS 1.36 9, 44 0.23 0.22 1.52 9, 31 0.19 0.31
 Univariate
  MADRS 1.07 3, 43.77 0.37 0.02 1.1 3, 52.75 0.35 0.03
  HAMA 2.8 3, 116.39 0.04* 0.05 3.14 3, 157.54 0.03* 0.08
  YMRS 1.99 2.57, 11.41 0.13a 0.04 3.39 3, 14.66 0.02* 0.08
Time contrasts (each time point contrasted to the subsequent)
 MADRS
  Baseline vs. week 3 0.56 1, 52 0.46 0.01 0.61 1, 39 0.44 0.02
  Week 3 vs. week 6 1.8 1, 52 0.19 0.03 2.02 1, 39 0.16 0.05
  Week 6 vs. week 12 0.09 1, 52 0.77 0 0.04 1, 39 0.85 0
 HAMA
  Baseline vs. week 3 0 1, 52 0.99 0 0 1, 39 1 0
  Week 3 vs. week 6 5.73 1, 52 0.02* 0.1 6.49 1, 39 0.02* 0.14
  Week 6 vs. week 12 0.02 1, 52 0.89 0 0.01 1, 39 0.92 0
 YMRS
  Baseline vs. week 3 0.32 1, 52 0.57 0.01 0 1, 39 0.96 0
  Week 3 vs. week 6 1.09 1, 52 0.3 0.02 0.16 1, 39 0.7 0
  Week 6 vs. week 12 6.41 1, 52 0.01* 0.11 6.56 1, 39 0.01* 0.14
  1. ITT intention-to-treat, PP per-protocol, MADRS Montgomery–Åsberg Depression Rating Scale, HAMA Hamilton Anxiety Rating Scale, YMRS Young Mania Rating Scale
  2. *p < 0.05
  3. aSphericity not assumed, Greenhouse–Geisser test used instead