Antidepressant efficacy of low-frequency repetitive transcranial magnetic stimulation in antidepressant-nonresponding bipolar depression: a single-blind randomized sham-controlled trial

International Journal of Bipolar Disorders

Table 3 ANOVA time * group interaction effects

	ITT				PP
	F	df	Sig	ηp2	F	df	Sig	ηp2
ANOVA across all time points
Multivariate
MADRS, HAMA, YMRS	1.36	9, 44	0.23	0.22	1.52	9, 31	0.19	0.31
Univariate
MADRS	1.07	3, 43.77	0.37	0.02	1.1	3, 52.75	0.35	0.03
HAMA	2.8	3, 116.39	0.04*	0.05	3.14	3, 157.54	0.03*	0.08
YMRS	1.99	2.57, 11.41	0.13^a	0.04	3.39	3, 14.66	0.02*	0.08
Time contrasts (each time point contrasted to the subsequent)
MADRS
Baseline vs. week 3	0.56	1, 52	0.46	0.01	0.61	1, 39	0.44	0.02
Week 3 vs. week 6	1.8	1, 52	0.19	0.03	2.02	1, 39	0.16	0.05
Week 6 vs. week 12	0.09	1, 52	0.77	0	0.04	1, 39	0.85	0
HAMA
Baseline vs. week 3	0	1, 52	0.99	0	0	1, 39	1	0
Week 3 vs. week 6	5.73	1, 52	0.02*	0.1	6.49	1, 39	0.02*	0.14
Week 6 vs. week 12	0.02	1, 52	0.89	0	0.01	1, 39	0.92	0
YMRS
Baseline vs. week 3	0.32	1, 52	0.57	0.01	0	1, 39	0.96	0
Week 3 vs. week 6	1.09	1, 52	0.3	0.02	0.16	1, 39	0.7	0
Week 6 vs. week 12	6.41	1, 52	0.01*	0.11	6.56	1, 39	0.01*	0.14

ITT intention-to-treat, PP per-protocol, MADRS Montgomery–Åsberg Depression Rating Scale, HAMA Hamilton Anxiety Rating Scale, YMRS Young Mania Rating Scale
*p < 0.05
^aSphericity not assumed, Greenhouse–Geisser test used instead