Table 1 Overview of case reports of psychedelics-induced mania
From: Psychedelics in the treatment of unipolar and bipolar depression
Clinical case | References |
|---|---|
• 21-year-old woman • Depression and PTSD, unmedicated • Positive family history of bipolar disorder (father and paternal grandmother) • Psychotic mania 36 h after ingestion of psilocybin-containing mushrooms • Stabilized with lithium and aripiprazole, later lamotrigine | Hendin and Penn, 2021 |
• 40-year-old male psychiatrist • Known bipolar disorder (a single previous manic episode) • Hospitalized with psychotic mania after self-medicating for depression: 1 g daily of vaporized DMT for 6 months, then plus phenelzine (60 mg p.o.) 3 weeks before the episode • Stabilization with lithium 1200 mg/d, paliperidone 6 mg/d, and clonazepam 3.5 mg/d • No follow-up possible | Brown et al., 2017b |
• 25-year-old male • Known bipolar disorder and history of cannabis abuse • Hospitalized with psychotic mania 2 days after ayahuasca ingestion • Remission with benperidole, olanzapine and lorazepam | Zellner et al., 2019 |
• 30-year-old male • Previous hypomanic episodes • Positive first-degree family history of bipolar disorder • Psychotic mania two days after a ayahuasca ritual • Stabilization with risperidone 2 mg/d and clonazepam 2 mg/d | Szmulewicz et al., 2015 |