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Table 2 Risk of bias from included randomised controlled trials

From: A systematic review of interventions in the early course of bipolar disorder I or II: a report of the International Society for Bipolar Disorders Taskforce on early intervention

Authors

Randomisation process

Deviations from intended interventions

Missing outcome data

Outcome measurement

Selection of reported results

Overall bias

Comparisons among early course populations

Berk et al. (2017)

Low

Low

Some concerns

Low

Some concerns

Some concerns

Conus et al. (2015)

Low

Low

Low

Low

Low

Low

Detke et al. (2015)

Low

Low

Low

Low

Low

Low

Kessing et al. (2013)

Low

Low

Low

Low

Low

Low

Kessing et al. (2014a)

Some concerns

Low

low

low

Some concerns

Some concerns

Miklowitz et al. (2003)

Low

Low

Some concerns

Low

Low

Some concerns

Miklowitz et al. (2008)

Low

Low

Low

Low

Low

Low

Miklowitz et al. (2014)

Low

Low

Low

Low

Low

Low

Patino et al. (2021)

Low

Low

Some concerns

Low

Low

Some concerns

Perry et al. (1999)

Low

Low

Low

Low

Low

Low

Strakowski et al. (2016)

High

Low

High

High

High

High

Comparisons across early vs later course of illness

Colom et al. (2010a,b)

Some concerns

Low

Low

Low

High

High

Ketter (2006)

Low

Low

Low

Low

High

High

Inder et al. (2015)

Low

Low

Low

Low

High

High

Scott et al. (2006)

Low

Low

Low

Low

Some concerns

Some concerns

Swann et al. (1999)

Some concerns

Low

Low

Some concerns

High

High