Table 3 Model 2: association between good and partial response to lithium, socio-demographic and clinical variables and DMRs
From: Methylomic biomarkers of lithium response in bipolar disorder: a clinical utility study
Variables | Beta | SE | Wald | df | p | VIF |
|---|---|---|---|---|---|---|
DMR24332 | − 0.248 | 0.093 | 7.167 | 1 | 0.007 | 3.461 |
Psychotic symptoms at onset | − 3.056 | 1.228 | 6.189 | 1 | 0.013 | 2.744 |
Lifetime alcohol misuse | 3.132 | 1.489 | 4.426 | 1 | 0.035 | 2.956 |
Family history of BD | 1.918 | 0.915 | 4.395 | 1 | 0.036 | 1.554 |
Polarity at onset | − 2.311 | 1.125 | 4.217 | 1 | 0.040 | 2.446 |
Lifetime number of hospitalizations | − 0.197 | 0.109 | 3.287 | 1 | 0.070 | 1.951 |
Smoking status | − 1.998 | 1.114 | 3.219 | 1 | 0.073 | 2.534 |
DMR106540 | − 0.268 | 0.152 | 3.089 | 1 | 0.079 | 1.987 |
Lithium as first MS | − 0.730 | 0.448 | 2.662 | 1 | 0.103 | 1.689 |
Lifetime cannabis misuse | 1.555 | 1.061 | 2.146 | 1 | 0.143 | 1.505 |
Constant | 30.983 | 14.192 | 4.766 | 1 | 0.029 |