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International Journal of Bipolar Disorders
Fig. 3 | International Journal of Bipolar Disorders

Fig. 3

From: Differential diagnosis of unipolar versus bipolar depression by GSK3 levels in peripheral blood: a pilot experimental study

Fig. 3

Comparison of GSK3 in patients with MDE diagnosed with UD relative to BD. A: representative western blots for total GSK3α and GSK3β (left) and for their respective phosphorylated forms (right). Bargraphs show that there is a statistically significant difference of total GSK3β between UD and D-BD C even after adjustment for age, sex, age at onset, duration of current MDE, medical and psychiatric comorbidities and HAM-D and HAM-A baseline levels (adjusted means D-BD: 0.711 ± 0.26, UD. 1.60 ± 0.18, p: 0.029). Dotted lines in C indicate arbitrary thresholds to differentiate UD from D-BD patients. There is no statistically significant difference in total GSK3α B, pGSK3α (D), pGSK3β E. Error bars represent SEM. (*P < 0.05)

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