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Table 1 Background characteristics of the included mother-infant dyads

From: High lithium concentration at delivery is a potential risk factor for adverse outcomes in breastfed infants: a retrospective cohort study

 

High exposure groupa

Low exposure groupb

All infants

N

Mean (SD)

N

Mean (SD)

N

Mean (SD)

Maternal characteristics

 Maternal age

7

33.1 (6.5)

18

32.9 (5.7)

25

33.0 (5.8)

 Pre-pregnancy BMI (kg/m2)

7

25.1 (4.7)

16

24.5 (3.6)

23

24.7 (3.9)

 

N

n (%)

N

n (%)

N

n(%)

Maternal diagnosis

 Bipolar disorder 1

7

1 (14.3)

18

11 (61.1)

25

12 (48.0)

 Bipolar disorder 2

7

3 (42.9)

18

5 (27.8)

25

8 (32.0)

 Bipolar disorder unspecified

7

2 (28.6)

18

0 (0.0)

25

2 (8.0)

  Other psychiatric diagnoses

7

1 (14.3)

18

2 (11.1)

25

3 (12.0)

  Other psychotropic medications

7

5 (71.4)

16

11 (68.8)

23

16 (69.6)

 Antidepressants

7

3 (42.9)

16

2 (12.5)

23

5 (21.7)

 Antipsychotics

7

1 (14.3)

16

3 (18.8)

23

4 (17.4)

 Anxiolytics and sedativesd

7

3 (42.9)

16

7 (43.8)

23

10 (43.5)

 Psychostimulants

7

1 (14.3)

16

3 (18.8)

23

4 (17.4)

  Living with the father of the child

7

7 (100.0)

16

13 (81.3)

23

20 (87.0)

Employment

 Full-time

7

1 (14.3)

16

6 (37.5)

23

7 (30.4)

 Part-time

7

2 (28.6)

16

6 (37.5)

23

8 (34.8)

 Not working or unemployed

7

4 (57.1)

16

4 (25.0)

23

8 (34.8)

Tobacco use 3 months pre pregnancy

 No smoking

6

3 (50.0)

16

11 (68.8)

22

17 (77.3)

 1–9 cigarettes/day

6

1 (16.7)

16

2 (12.5)

22

3 (13.6)

 > 10 cigarettes/day

6

1 (16.7)

16

3 (18.8)

22

4 (18.2)

 Snuff

6

1 (16.7)

16

0 (0.0)

22

1 (4.5)

Alcohol use 3 months pre pregnancy

 Never

6

3 (50.0)

15

6 (40.0)

21

9 (42.9)

 ≤ 1 time/week

6

3 (50.0)

15

6 (40.0)

21

9 (42.9)

 > 1 time/week

6

0 (0.0)

15

3 (20.0)

21

3 (14.3)

Alcohol use in first trimester

 Never

7

7 (100.0)

16

16 (100.0)

23

23 (100.0)

Pregnancy and infant characteristics

 Delivery mode

  Vaginal delivery

6

3 (50.0)

18

15 (83.3)

24

18 (75.0)

  Instrumental delivery

6

1 (16.7)

18

3 (16.7)

24

4 (16.7)

  Caesarean section, elective

6

1 (16.7)

18

0 (0.0)

24

1 (4.2)

  Caesarean section, emergency

6

1 (16.7)

18

0 (0.0)

24

1 (4.2)

    Pregnancy complicationse

7

2 (28.7)

18

2 (11.2)

25

4 (16.0)

Infant sex

 Female

7

3 (42.9)

18

15 (83.3)

25

18 (72.0)

  1. aInfant serum lithium concentration ≥ 0.6meqv/l
  2. bInfant serum lithium concentration < 0.6meqv/l
  3. cIndependent sample t-test and Fisher’s exact tests were used to test group differences between the high exposure and the low exposure groups in continuous and nominal variables, respectively
  4. dZolpidem, Zopiclone, Oxycodone, Oxazepam, Propiomazine, Promethazine, Nitrazepam
  5. ePregnancy complications: hypertonia, polyhydramnios, elevated liver enzymes, hypothyroidism, hyperemesis gravidarum