From: Lifetime risk of severe kidney disease in lithium-treated patients: a retrospective study
 |  |  |  | 95%CI for HR |  | |
---|---|---|---|---|---|---|
Variable | Category | Reference | HR | Lower | Upper | p-value |
Sex | 0 (men) | REF | Â | Â | Â | Â |
 | 1 (women) |  | 1.18 | 0.77 | 1.81 | 0.440 |
Start age | 0 (18–34 years) | REF |  |  |  |  |
 | 1 (35–44 years) |  | 3.20 | 1.37 | 7.45 | 0.007 |
 | 2 (45–54 years) |  | 3.18 | 1.37 | 7.39 | 0.007 |
 | 3 (55–64 years) |  | 3.80 | 1.64 | 8.79 | 0.002 |
 | 4 (65–74 years) |  | 8.25 | 3.60 | 18.90 |  < 0.001 |
 | 5 (≥ 75 years) |  | 3.29 | 1.02 | 10.64 | 0.047 |
Start creatinine | 0 (lower third) | REF | Â | Â | Â | Â |
 | 1 (middle third) |  | 2.02 | 1.29 | 3.17 | 0.002 |
 | 2 (upper third) |  | 4.60 | 2.75 | 7.68 |  < 0.001 |