Table 1 Clinical and biological factors of good lithium response
From: Effectiveness of ultra-long-term lithium treatment: relevant factors and case series
Clinical | Biological |
|---|---|
Episodic course with periods of complete remissions Pattern of mania-depression-interval Absence of psychotic episodes Non-rapid-cycling course Later onset of illness Short duration of the illness before lithium administration Low psychiatric comorbidity Hyperthymic temperament High social status Social support Good compliance No history of childhood abuse | Different effect on induced pluripotent stem cells Different effect on lymphoblastoid cell lines Candidate genes, including genes involved in stress response and “clock” genes Genes for lncRNA on chromosome 21 (ConLiGen GWAS research) Worse response with polygenic risk score for schizophrenia, major depression and attention-deficit/hyperactivity disorder Genes for HLA-mediated low inflammation Differences in methylated regions (genome wide methylomic study) |