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Table 1 Sociodemographic and clinical characteristics between RCBD and NRCBD. Significance with Bonferroni correction requires p < 0.0012 (0.05/41)

From: Sociodemographic, clinical and treatment characteristics of current rapid-cycling bipolar disorder: a multicenter Chinese study

Variables

Total (n = 520)

RCBD (n = 49)

NRCBD (n = 471)

t/Z/χ2

P

Sociodemographic characteristics

 Gender (male)

252(48.46)

20(40.82)

232(49.26)

1.2660

0.2605

 Age (years)

35.65 ± 13.23

34.29 ± 13.00

35.80 ± 13.26

− 0.76

0.4499

 Education (years)

13.10 ± 3.40

13.18 ± 3.52

13.09 ± 3.39

0.19

0.8519

 Occupational status

   

0.4617

0.7939

  Permanent employment

221(42.50)

22(44.90)

199(42.25)

  

  Temporary employment

69(13.27)

5(10.20)

64(13.59)

  

   Unemployed

230(44.23)

22(44.90)

208(44.16)

  

 Residential status

   

–

0.5790

  Living alone

42(8.08)

5(10.20)

37(7.86)

  

  Cohabitation

478(91.92)

44(89.80)

434(92.14)

  

 Lifetime clinical characteristics

 Substance abuse

36(6.92)

2(4.08)

34(7.22)

–

0.5620

 Family history of mental disorders

151(29.04)

16(32.65)

135(28.66)

0.3430

0.5581

Bipolar type

   

0.7280

0.3935

  Type I

399(76.73)

40(81.63)

359(76.22)

  

  Type II

121(23.27)

9(18.37)

112(23.78)

  

 Age at onset (years)

30.39 ± 12.21

31.01 ± 13.11

30.32 ± 12.12

0.38

0.7059

 Age at diagnosis (years)

32.28 ± 12.46

31.61 ± 13.0

32.35 ± 12.41

− 0.40

0.6930

 Time from first psychiatric consultation to diagnosis of BD (years) (Mean ± SD)

3.46 ± 6.13

2.46 ± 6.81

3.57 ± 6.05

5.0762

0.0243

 Psychiatric diagnosis prior BD

   

4.4707

0.2149

  Major depressive disorder

227(43.65)

24(48.98)

203(43.10)

  

  Schizophrenia

84(16.15)

3(6.12)

81(17.20)

  

  Anxiety Disorder

39(7.50)

3(6.12)

36(7.64)

  

  Other mental disorders

170(32.69)

19(38.78)

151(32.06)

  

 Polarity of initial episode

   

–

0.0775

  Manic episode

172(33.08)

11(33.08)

161(22.45)

  

  Hypomanic episode

19(3.65)

2(4.08)

17(3.61)

  

  Depressive episode

307(59.04)

31(63.27)

276(58.60)

  

  Mixed episode

22(4.23)

5(10.20)

17(3.61)

  

  Psychotic feature

217(41.73)

18(36.73)

199(42.25)

0.5553

0.4562

 Longest duration of euthymia post-diagnosis (days) (n = 247)

882.38 ± 1318.71

573.85 ± 841.84

918.67 ± 1360.67

5.6006

0.0180

 Lifetime hospitalization history due to BD

415(79.81)

32(65.31)

383(81.32)

7.0596

0.0079

 Lifetime number of hospitalizations due to BD

1.92 ± 1.51

1.91 ± 1.55

1.92 ± 1.51

0.4041

0.5250

 Lifetime suicide attempts

54(10.38)

8(16.33)

46(9.77)

2.0524

0.1520

 Number of lifetime suicide attempts

0.17 ± 0.67

0.29 ± 0.84

0.15 ± 0.64

0.7547

0.3850

Clinical characteristics in the past 12 months

 

 Number of episodes in the last 12 months (Mean ± SD)

     

  Manic episode

0.30 ± 0.75

1.22 ± 1.79

0.20 ± 0.43

21.4834

 < 0.001

  Hypomanic episode

0.73 ± 1.04

1.73 ± 2.44

0.63 ± 0.69

14.98

 < 0.001

  Depressive episode

1.03 ± 1.07

2.63 ± 2.21

0.86 ± 0.69

71.65

 < 0.001

  Mixed episode

0.15 ± 0.61

0.63 ± 1.65

0.10 ± 0.31

17.09

 < 0.001

 Total number of episodes in the last 12 months (Mean ± SD)

2.22 ± 1.91

6.24 ± 4.01

1.80 ± 0.71

150.7186

 < 0.001

 Hospitalization history due to BD in the past 12 months

348(66.92)

27(55.10)

321(68.51)

3.4150

0.0646

 Number of hospitalizations due to BD in the past 12 months

1.23 ± 0.53

0.97 ± 0.59

1.04 ± 0.67

0.4083

0.5228

 Suicide attempts in the past 12 months

32(6.15)

5(10.20)

27(5.73)

-

0.2107

 Number of suicide attempts in the past 12 months

0.08 ± 0.35

0.18 ± 0.75

0.06 ± 0.27

0.2603

0.6099

  1. BD bipolar disorder; RCBD rapid cycling bipolar disorder; NRCBD non-rapid cycling bipolar disorder