Articles
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Citation: International Journal of Bipolar Disorders 2024 12:26
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The influence of PER3 VNTR genotypes on the age of onset in a group of bipolar I disorder patients: an exploratory study
PER3 is a circadian gene that contains a variable number of tandem repeats (VNTR) which codifies for three genotypes: 4/4; 4/5; and 5/5 and is involved in non-visual response to light, a critical process associat...
Citation: International Journal of Bipolar Disorders 2024 12:25 -
Correction: Type of cycle, temperament and childhood trauma are associated with lithium response in patients with bipolar disorders
Citation: International Journal of Bipolar Disorders 2024 12:24 -
Lithium and its effects: does dose matter?
Decades of clinical research have demonstrated the efficacy of lithium in treating acute episodes (both manic and depressive), as well as in preventing recurrences of bipolar disorder (BD). Specific to lithium...
Citation: International Journal of Bipolar Disorders 2024 12:23 -
The research landscape of bipolar disorder in Germany: productive, but underfunded
The recurrent mental illness bipolar disorder is a major burden on the healthcare system, which underlines the importance of research into this disease. Germany is one of the most productive countries in this ...
Citation: International Journal of Bipolar Disorders 2024 12:22 -
Pilot study of circulating cell-free mitochondrial DNA in relation to brain structure in youth bipolar disorder
Mitochondrial dysfunction is implicated in the neuropathology of bipolar disorder (BD). Higher circulating cell-free mitochondrial DNA (ccf-mtDNA), generally reflecting poorer mitochondrial health, has been as...
Citation: International Journal of Bipolar Disorders 2024 12:21 -
Exploring the genetics of lithium response in bipolar disorders
Lithium (Li) remains the treatment of choice for bipolar disorders (BP). Its mood-stabilizing effects help reduce the long-term burden of mania, depression and suicide risk in patients with BP. It also has bee...
Citation: International Journal of Bipolar Disorders 2024 12:20 -
Integrated proteomic and genomic analysis to identify predictive biomarkers for valproate response in bipolar disorder: a 6-month follow-up study
Several genetic studies have been undertaken to elucidate the intricate interplay between genetics and drug responses in bipolar disorder (BD). However, there has been notably limited research on biomarkers sp...
Citation: International Journal of Bipolar Disorders 2024 12:19 -
A systematic review of the biomarkers associated with cognition and mood state in bipolar disorder
Bipolar disorder (BD) is a severe psychiatric disorder characterized by changes in mood that alternate between (hypo) mania or depression and mixed states, often associated with functional impairment and cogni...
Citation: International Journal of Bipolar Disorders 2024 12:18 -
Lithium-discontinuation-induced treatment refractoriness revisited
Lithium is effective in the long-term treatment of bipolar disorder. Concerns have been raised about non-responsiveness after discontinuation and resuming previously effective lithium prophylaxis. We reviewed ...
Citation: International Journal of Bipolar Disorders 2024 12:17 -
Towards a natural treatment for mania: red onion husk extract modulates neuronal resilience, redox signalling, and glial activation
Red onion husk, a readily available agricultural waste material, contains diverse bioactive compounds with potential health benefits. This study aimed to assess the safety and therapeutic potential of red onio...
Citation: International Journal of Bipolar Disorders 2024 12:16 -
Medical comorbidities in bipolar disorder (BIPCOM): clinical validation of risk factors and biomarkers to improve prevention and treatment. Study protocol
BIPCOM aims to (1) identify medical comorbidities in people with bipolar disorder (BD); (2) examine risk factors and clinical profiles of Medical Comorbidities (MC) in this clinical group, with a special focus...
Citation: International Journal of Bipolar Disorders 2024 12:15 -
Combining predominant polarity and affective spectrum concepts in bipolar disorder: towards a novel theoretical and clinical perspective
This is an overview of recent advances on predominant polarity conceptualization in bipolar disorder (BD). Current evidence on its operationalized definitions, possible contextualization within the affective s...
Citation: International Journal of Bipolar Disorders 2024 12:14 -
Cluster analysis exploring the impact of childhood neglect on cognitive function in patients with bipolar disorder
Bipolar disorder (BD) is a severe mental disorder related to neurocognitive deficits. Exposure to childhood trauma is associated with worse cognitive performance. Different compositions of childhood trauma in ...
Citation: International Journal of Bipolar Disorders 2024 12:13 -
Longitudinal studies of bipolar patients and their families: translating findings to advance individualized risk prediction, treatment and research
Bipolar disorder is a broad diagnostic construct associated with significant phenotypic and genetic heterogeneity challenging progress in clinical practice and discovery research. Prospective studies of well-c...
Citation: International Journal of Bipolar Disorders 2024 12:12 -
Sociodemographic, clinical and treatment characteristics of current rapid-cycling bipolar disorder: a multicenter Chinese study
Rapid cycling bipolar disorder (RCBD), characterized by four or more episodes per year, is a complex subtype of bipolar disorder (BD) with poorly understood characteristics.
Citation: International Journal of Bipolar Disorders 2024 12:11 -
Type of cycle, temperament and childhood trauma are associated with lithium response in patients with bipolar disorders
Lithium stands as the gold standard in treating bipolar disorders (BD). Despite numerous clinical factors being associated with a favorable response to lithium, comprehensive studies examining the collective i...
Citation: International Journal of Bipolar Disorders 2024 12:10 -
How effective are mood stabilizers in treating bipolar patients comorbid with cPTSD? Results from an observational study
Multiple traumatic experiences, particularly in childhood, may predict and be a risk factor for the development of complex post-traumatic stress disorder (cPTSD). Unfortunately, individuals with bipolar disord...
Citation: International Journal of Bipolar Disorders 2024 12:9 -
Perceived loneliness and social support in bipolar disorder: relation to suicidal ideation and attempts
The suicide rate in bipolar disorder (BD) is among the highest across all psychiatric disorders. Identifying modifiable variables that relate to suicidal thoughts and behaviors (STBs) in BD may inform preventi...
Citation: International Journal of Bipolar Disorders 2024 12:8 -
Effectiveness of ultra-long-term lithium treatment: relevant factors and case series
The phenomenon of preventing the recurrences of mood disorders by the long-term lithium administration was discovered sixty years ago. Such a property of lithium has been unequivocally confirmed in subsequent ...
Citation: International Journal of Bipolar Disorders 2024 12:7 -
Prevention of suicidal behavior with lithium treatment in patients with recurrent mood disorders
Suicidal behavior is more prevalent in bipolar disorders than in other psychiatric illnesses. In the last thirty years evidence has emerged to indicate that long-term treatment of bipolar disorder patients wit...
Citation: International Journal of Bipolar Disorders 2024 12:6 -
Correlations between multimodal neuroimaging and peripheral inflammation in different subtypes and mood states of bipolar disorder: a systematic review
Systemic inflammation-immune dysregulation and brain abnormalities are believed to contribute to the pathogenesis of bipolar disorder (BD). However, the connections between peripheral inflammation and the brai...
Citation: International Journal of Bipolar Disorders 2024 12:5 -
Lithium: how low can you go?
Citation: International Journal of Bipolar Disorders 2024 12:4 -
Why is lithium [not] the drug of choice for bipolar disorder? a controversy between science and clinical practice
During over half a century, science has shown that lithium is the most efficacious treatment for bipolar disorder but despite this, its prescription has consistently declined internationally during recent deca...
Citation: International Journal of Bipolar Disorders 2024 12:3 -
Biomarkers for neurodegeneration impact cognitive function: a longitudinal 1-year case–control study of patients with bipolar disorder and healthy control individuals
Abnormalities in cerebrospinal fluid (CSF)-amyloid-beta (Aβ)42, CSF-Aβ40, CSF-Aβ38, CSF-soluble amyloid precursor proteins α and β, CSF-total-tau, CSF-phosphorylated-tau, CSF-neurofilament light protein (NF-L)...
Citation: International Journal of Bipolar Disorders 2024 12:2 -
Cognitive behavioural therapy for social anxiety disorder in people with bipolar disorder: a case series
Social anxiety disorder increases the likelihood of unfavourable outcomes in people with bipolar disorder. Cognitive behavioural therapy (CBT) is the first-line treatment for social anxiety disorder. However, ...
Citation: International Journal of Bipolar Disorders 2024 12:1 -
Lithium prescription trends in psychiatric inpatient care 2014 to 2021: data from a Bavarian drug surveillance project
Lithium (Li) remains one of the most valuable treatment options for mood disorders. However, current knowledge about prescription practices in Germany is limited. The objective of this study is to estimate the...
Citation: International Journal of Bipolar Disorders 2023 11:40 -
Lifetime risk of severe kidney disease in lithium-treated patients: a retrospective study
Lithium is an essential psychopharmaceutical, yet side effects and concerns about severe renal function impairment limit its usage.
Citation: International Journal of Bipolar Disorders 2023 11:39 -
Factors associated with suicide attempts in the antecedent illness trajectory of bipolar disorder and schizophrenia
Factors associated with suicide attempts during the antecedent illness trajectory of bipolar disorder (BD) and schizophrenia (SZ) are poorly understood.
Citation: International Journal of Bipolar Disorders 2023 11:38 -
Behavioral lateralization in bipolar disorders: a systematic review
Bipolar disorder (BD) is often seen as a bridge between schizophrenia and depression in terms of symptomatology and etiology. Interestingly, hemispheric asymmetries as well as behavioral lateralization are shi...
Citation: International Journal of Bipolar Disorders 2023 11:37 -
High lithium concentration at delivery is a potential risk factor for adverse outcomes in breastfed infants: a retrospective cohort study
Neonatal effects of late intrauterine and early postpartum exposure to lithium through mother’s own milk are scarcely studied. It is unclear whether described symptoms in breastfed neonates are caused by place...
Citation: International Journal of Bipolar Disorders 2023 11:36 -
Key questions on the long term renal effects of lithium: a review of pertinent data
For over half a century, it has been widely known that lithium is the most efficacious maintenance treatment for bipolar disorder. Despite thorough research on the long-term effects of lithium on renal functio...
Citation: International Journal of Bipolar Disorders 2023 11:35 -
Controversies regarding lithium-associated weight gain: case–control study of real-world drug safety data
The impact of long-term lithium treatment on weight gain has been a controversial topic with conflicting evidence. We aim to assess reporting of weight gain associated with lithium and other mood stabilizers c...
Citation: International Journal of Bipolar Disorders 2023 11:34 -
Differential diagnosis of unipolar versus bipolar depression by GSK3 levels in peripheral blood: a pilot experimental study
The differential diagnosis of patients presenting for the first time with a depressive episode into unipolar disorder versus bipolar disorder is crucial to establish the correct pharmacological therapy (antide...
Citation: International Journal of Bipolar Disorders 2023 11:33 -
Supra-second interval timing in bipolar disorder: examining the role of disorder sub-type, mood, and medication status
Widely reported by bipolar disorder (BD) patients, cognitive symptoms, including deficits in executive function, memory, attention, and timing are under-studied. Work suggests that individuals with BD show imp...
Citation: International Journal of Bipolar Disorders 2023 11:32 -
Association between childhood trauma, cognition, and psychosocial function in a large sample of partially or fully remitted patients with bipolar disorder and healthy participants
Childhood trauma (CT) are frequently reported by patients with bipolar disorder (BD), but it is unclear whether and how CT contribute to patients’ cognitive and psychosocial impairments. We aimed to examine th...
Citation: International Journal of Bipolar Disorders 2023 11:31 -
Countering the declining use of lithium therapy: a call to arms
For over half a century, it has been widely known that lithium is the most efficacious treatment for bipolar disorder. Yet, despite this, its prescription has consistently declined over this same period of tim...
Citation: International Journal of Bipolar Disorders 2023 11:30 -
Paediatric bipolar disorder: an age-old problem
Citation: International Journal of Bipolar Disorders 2023 11:29 -
NRX-101 (D-cycloserine plus lurasidone) vs. lurasidone for the maintenance of initial stabilization after ketamine in patients with severe bipolar depression with acute suicidal ideation and behavior: a randomized prospective phase 2 trial
We tested the hypothesis that, after initial improvement with intravenous ketamine in patients with bipolar disorder (BD) with severe depression and acute suicidal thinking or behavior, a fixed-dose combinatio...
Citation: International Journal of Bipolar Disorders 2023 11:28 -
The IBER study: a feasibility randomised controlled trial of imagery based emotion regulation for the treatment of anxiety in bipolar disorder
Intrusive mental imagery is associated with anxiety and mood instability within bipolar disorder and therefore represents a novel treatment target. Imagery Based Emotion Regulation (IBER) is a brief structured...
Citation: International Journal of Bipolar Disorders 2023 11:27 -
Mitochondrial genetic variants associated with bipolar disorder and Schizophrenia in a Japanese population
Bipolar disorder (BD) and schizophrenia (SZ) are complex psychotic disorders (PSY), with both environmental and genetic factors including possible maternal inheritance playing a role. Some studies have investi...
Citation: International Journal of Bipolar Disorders 2023 11:26 -
Differential characteristics of bipolar I and II disorders: a retrospective, cross-sectional evaluation of clinical features, illness course, and response to treatment
The distinction between bipolar I and bipolar II disorder and its treatment implications have been a matter of ongoing debate. The aim of this study was to examine differences between patients with bipolar I a...
Citation: International Journal of Bipolar Disorders 2023 11:25 -
Neonatal admission after lithium use in pregnant women with bipolar disorders: a retrospective cohort study
Lithium is the preferred treatment for pregnant women with bipolar disorders (BD), as it is most effective in preventing postpartum relapse. Although it has been prescribed during pregnancy for decades, the sa...
Citation: International Journal of Bipolar Disorders 2023 11:24 -
Rates and associations of relapse over 5 years of 2649 people with bipolar disorder: a retrospective UK cohort study
Evidence regarding the rate of relapse in people with bipolar disorder (BD), particularly from the UK, is lacking. This study aimed to evaluate the rate and associations of clinician-defined relapse over 5 yea...
Citation: International Journal of Bipolar Disorders 2023 11:23 -
Exploratory study of ultraviolet B (UVB) radiation and age of onset of bipolar disorder
Sunlight contains ultraviolet B (UVB) radiation that triggers the production of vitamin D by skin. Vitamin D has widespread effects on brain function in both developing and adult brains. However, many people l...
Citation: International Journal of Bipolar Disorders 2023 11:22 -
Characteristics of rapid cycling in 1261 bipolar disorder patients
Rapid-cycling (RC; ≥ 4 episodes/year) in bipolar disorder (BD) has been recognized since the 1970s and associated with inferior treatment response. However, associations of single years of RC with overall cycl...
Citation: International Journal of Bipolar Disorders 2023 11:21 -
Clinicians’ preferences and attitudes towards the use of lithium in the maintenance treatment of bipolar disorders around the world: a survey from the ISBD Lithium task force
Lithium has long been considered the gold-standard pharmacological treatment for the maintenance treatment of bipolar disorders (BD) which is supported by a wide body of evidence. Prior research has shown a st...
Citation: International Journal of Bipolar Disorders 2023 11:20 -
Phenotype fingerprinting of bipolar disorder prodrome
Detecting prodromal symptoms of bipolar disorder (BD) has garnered significant attention in recent research, as early intervention could potentially improve therapeutic efficacy and improve patient outcomes. T...
Citation: International Journal of Bipolar Disorders 2023 11:19 -
Predictors of adherence to electronic self-monitoring in patients with bipolar disorder: a contactless study using Growth Mixture Models
Several studies have reported on the feasibility of electronic (e-)monitoring using computers or smartphones in patients with mental disorders, including bipolar disorder (BD). While studies on e-monitoring ha...
Citation: International Journal of Bipolar Disorders 2023 11:18 -
Racial differences in the major clinical symptom domains of bipolar disorder
Across clinical settings, black individuals are disproportionately less likely to be diagnosed with bipolar disorder compared to schizophrenia, a traditionally more severe and chronic disorder with lower expec...
Citation: International Journal of Bipolar Disorders 2023 11:17
- ISSN: 2194-7511 (electronic)