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  1. With two recent systematic reviews and meta-analyses on the efficacy of lithium compared to placebo and other treatment options, it can now be concluded that lithium is the only drug that has been shown effica...

    Authors: Willem A Nolen

    Citation: International Journal of Bipolar Disorders 2015 3:1

    Content type: Letter to the Editor

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  2. Cognitive impairment in patients with bipolar disorder (BD) is not restricted to symptomatic phases. It is also present in euthymia. There is evidence of differences in the brain’s structure between bipolar pa...

    Authors: Andrea Pfennig, Martin Alda, Trevor Young, Glenda MacQueen, Janusz Rybakowski, Aleksandra Suwalska, Christian Simhandl, Barbara König, Tomas Hajek, Claire O’Donovan, Dirk Wittekind, Susanne von Quillfeldt, Jana Ploch, Cathrin Sauer and Michael Bauer

    Citation: International Journal of Bipolar Disorders 2014 2:16

    Content type: Research

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  3. In a previous meta-analysis of randomized controlled trials comparing lithium with placebo as a long-term treatment in bipolar disorders, we observed a clear preventative effect for manic episodes; however, th...

    Authors: Emanuel Severus, Matthew J Taylor, Cathrin Sauer, Andrea Pfennig, Philipp Ritter, Michael Bauer and John R Geddes

    Citation: International Journal of Bipolar Disorders 2014 2:15

    Content type: Research

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  4. Quetiapine extended release (XR) and lithium are treatments with proven efficacy in acute mania. This randomized study evaluated the efficacy and safety of lithium or placebo as add-on to quetiapine XR in adul...

    Authors: Michel S Bourin, Emanuel Severus, Juan P Schronen, Peter Gass, Johan Szamosi, Hans Eriksson and Hongally Chandrashekar

    Citation: International Journal of Bipolar Disorders 2014 2:14

    Content type: Research

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  5. Lithium as a gold standard therapy for bipolar disorder is well known to have a number of medical comorbidities that impact renal, parathyroid, and thyroid function. Despite these medical comorbidities, there ...

    Authors: Manuel E Fuentes Salgado, Bruce Sutor, Robert C Albright and Mark A Frye

    Citation: International Journal of Bipolar Disorders 2014 2:12

    Content type: Letter to the Editor

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  6. Compliance is a key factor in the maintenance treatment of bipolar disorder. This noninterventional study was conducted to explore factors associated with higher levels of compliance in bipolar patients, all t...

    Authors: Alexandra Kutzelnigg, Martin Kopeinig, Chih-Ken Chen, Ágnes Fábián, María Gloria Pujol-Luna, Young-chul Shin, Tamás Treuer, Yulia D'yachkova, Claudia Deix, Siegfried Kasper and Dagmar Doby

    Citation: International Journal of Bipolar Disorders 2014 2:13

    Content type: Research

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  7. Studies from the USA suggest that rates of pediatric bipolar disorder have increased since the mid-90s, but no study outside the USA has been published on the rates of pediatric bipolar disorder. Further, it i...

    Authors: Lars Vedel Kessing, Eleni Vradi and Per Kragh Andersen

    Citation: International Journal of Bipolar Disorders 2014 2:10

    Content type: Research

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  8. The nature of mood variation in bipolar disorder has been the subject of relatively little research because detailed time series data has been difficult to obtain until recently. However some papers have addre...

    Authors: Paul J Moore, Max A Little, Patrick E McSharry, Guy M Goodwin and John R Geddes

    Citation: International Journal of Bipolar Disorders 2014 2:11

    Content type: Research

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  9. When analysing and reporting data from long-term drug trials in bipolar disorder, it has become the standard to break down the outcome into the prevention of mania and the prevention of depression. However, as...

    Authors: Rasmus Wentzer Licht and Emanuel Severus

    Citation: International Journal of Bipolar Disorders 2014 2:8

    Content type: Letter to the Editor

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  10. The lateral hypothalamus integrates critical physiological functions such as the sleep-wake cycle, energy expenditure, and sexual behaviors. These functions are severely dysregulated during mania. In this stud...

    Authors: Osama A Abulseoud, Ulas M Camsari, Christina L Ruby, Khalid Mohamed, Noha M Abdel Gawad, Aimen Kasasbeh, Mehmet Y Yüksel and Doo-Sup Choi

    Citation: International Journal of Bipolar Disorders 2014 2:7

    Content type: Research

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  11. Bipolar disorder (BD) is a common, severe mental disorder with a high recurrence rate. Lithium (Li) is the cornerstone of BD treatments to reduce recurrence, suicide, and mortality risks. However, only 30% of ...

    Authors: Pierre Alexis Geoffroy, Bruno Etain, Sarah Sportiche and Frank Bellivier

    Citation: International Journal of Bipolar Disorders 2014 2:5

    Content type: Letter to the Editor

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  12. Bipolar disorder is a highly heritable illness that onsets in adolescence and young adulthood. We examined gene expression (mRNA) and protein levels of candidate immune and neurotrophic markers in well-charact...

    Authors: Anne Duffy, Julie Horrocks, Sarah Doucette, Charles Keown-Stoneman, Paul Grof, Ana Andreazza and L Trevor Young

    Citation: International Journal of Bipolar Disorders 2014 2:4

    Content type: Research

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  13. Reduction of the stigma of mental illness is an international priority; arts- and contact-based approaches represent a promising mode of intervention. This project was designed to explore the impact of a one-w...

    Authors: Erin E Michalak, James D Livingston, Victoria Maxwell, Rachelle Hole, Lisa D Hawke and Sagar V Parikh

    Citation: International Journal of Bipolar Disorders 2014 2:1

    Content type: Research

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  14. Bipolar disorder (BD) is a complex psychiatric phenotype with a high heritability and a multifactorial etiology. Multisite collaborative efforts using genome-wide association studies (GWAS) have identified onl...

    Authors: John S Strauss, Tarang Khare, Vincenzo De Luca, Richie Jeremian, James L Kennedy, John B Vincent and Arturas Petronis

    Citation: International Journal of Bipolar Disorders 2013 1:28

    Content type: Research

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  15. Bipolar disorder may be associated with a hypersensitive behavioral approach system and therefore to increased reward sensitivity. The objective of this study is to explore the interrelationships between bipol...

    Authors: Ran Sapir, Ada H Zohar, Yuly Bersudsky, RH Belmaker and Yamima Osher

    Citation: International Journal of Bipolar Disorders 2013 1:27

    Content type: Research

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  16. This study analyzed regularity in the daily dosage of antidepressants taken by patients with bipolar disorder and identified the factors associated with irregularity.

    Authors: Rita Bauer, Tasha Glenn, Martin Alda, Kemal Sagduyu, Wendy Marsh, Paul Grof, Rodrigo Munoz, Greg Murray, Philipp Ritter, Ute Lewitzka, Emanuel Severus, Peter C Whybrow and Michael Bauer

    Citation: International Journal of Bipolar Disorders 2013 1:26

    Content type: Research

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  17. Eating disorder (ED) patients often have comorbidities with other psychiatric disorders, especially with mood disorders. Although recent studies suggest an intimate relationship between ED and bipolar disorder...

    Authors: Rodolfo Nunes Campos, Rodrigues Domingos dos Santos Junior, Táki Athanássios Cordás, Jules Angst and Ricardo Alberto Moreno

    Citation: International Journal of Bipolar Disorders 2013 1:25

    Content type: Research

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  18. This pilot study examines the proof of concept of a consolidated Nutrition, Exercise, and Wellness Treatment (NEW Tx) for overweight individuals with bipolar disorder.

    Authors: Louisa G Sylvia, Stephanie Salcedo, Emily E Bernstein, Ji Hyun Baek, Andrew A Nierenberg and Thilo Deckersbach

    Citation: International Journal of Bipolar Disorders 2013 1:24

    Content type: Short communication

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  19. Distress and/or dysfunction are well established as key reasons for help-seeking. We explore the characteristics of groups defined by high or low distress or disability in young people with unipolar depression...

    Authors: Elizabeth M Scott, Daniel F Hermens, Sharon L Naismith, Adam J Guastella, Django White, Bradley G Whitwell, Jim Lagopoulos, Jan Scott and Ian B Hickie

    Citation: International Journal of Bipolar Disorders 2013 1:23

    Content type: Research

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  20. The Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5), includes a new 'With Mixed Features’ specifier for mood episodes. In (hypo-)manic episodes, the specifier is given if three or ...

    Authors: Thierry Hergueta and Emmanuelle Weiller

    Citation: International Journal of Bipolar Disorders 2013 1:21

    Content type: Research

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  21. Authors: Daniela Reginaldi, Alexia Koukopoulos, Ross J Baldessarini, Gianni L Faedda, Giuseppe Fazzari, Paolo Girardi, Giorgio Kotzalidis, Giovanni Manfredi, Gian Paolo Minnai, Isabella Pacchiarotti, Michele Raja, Gabriele Sani, Gino Serra, Leonardo Tondo and Eduard Vieta

    Citation: International Journal of Bipolar Disorders 2013 1:17

    Content type: Obituary

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  22. Glial dysfunction has been purported to be important to the pathophysiology of bipolar illness. However, manic behavior has not been previously demonstrated to result as a consequence of glial pathology. The a...

    Authors: Yonglin Gao, Malhar Jhaveri, Zhenmin Lei, Brandy L Chaneb, Jerry Lingrel and Rif S El-Mallakh

    Citation: International Journal of Bipolar Disorders 2013 1:20

    Content type: Research

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  23. Mood elevation is common in adolescents and young adults. The aim of this study was to investigate the prevalence of a bipolar diagnosis and co-morbidity in individuals identified by online screening for exper...

    Authors: Philippa L Rock, Rebecca A Chandler, Catherine J Harmer, Robert D Rogers and Guy M Goodwin

    Citation: International Journal of Bipolar Disorders 2013 1:19

    Content type: Research

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  24. Lithium-induced hyperparathyroidism (LIH) is a relative underrecognized complication of long-term lithium treatment. Hypercalcemia may be the first, but often overlooked, sign of LIH. Symptoms of LIH can be si...

    Authors: Bas A Twigt, Bernard M Houweling, Menno R Vriens, Eline J Regeer, Ralph W Kupka, Inne HM Borel Rinkes and Gerlof D Valk

    Citation: International Journal of Bipolar Disorders 2013 1:18

    Content type: Research

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  25. Poor sleep quality is known to precede the onset of mood episodes and to be associated with poor treatment outcomes in bipolar disorder (BD). We sought to identify modifiable factors that correlate with poor s...

    Authors: Erika FH Saunders, Danielle M Novick, Julio Fernandez-Mendoza, Masoud Kamali, Kelly A Ryan, Scott A Langenecker, Alan J Gelenberg and Melvin G McInnis

    Citation: International Journal of Bipolar Disorders 2013 1:16

    Content type: Research

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  26. Comorbid anxiety disorders are extremely prevalent in bipolar disorder (BD) and have substantial impact on the course of illness. Limited evidence regarding treatment factors has led to a renewal of research e...

    Authors: Lisa D Hawke, Vytas Velyvis and Sagar V Parikh

    Citation: International Journal of Bipolar Disorders 2013 1:15

    Content type: Research

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  27. The diagnostic classification of mood disorders by the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR) had two major shortcomings: an underdiagnosis of bipolar disorders and a large proportion o...

    Authors: Jules Angst

    Citation: International Journal of Bipolar Disorders 2013 1:12

    Content type: Short communication

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  28. Eating disorders (ED) are noted to occur with bipolar disorder (BD), but relationships between additional comorbidities, clinical correlates, and personality factors common to both remain largely unknown.

    Authors: Andrew Jen, Erika FH Saunders, Rollyn M Ornstein, Masoud Kamali and Melvin G McInnis

    Citation: International Journal of Bipolar Disorders 2013 1:13

    Content type: Research

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  29. The purpose of this study was to investigate the effectiveness and stability of long-term lithium treatment in a prospective, international, multicenter cohort of bipolar patients in a naturalistic setting.

    Authors: Anne Berghöfer, Martin Alda, Mazda Adli, Christopher Baethge, Michael Bauer, Tom Bschor, Paul Grof, Bruno Müller-Oerlinghausen, Janusz K Rybakowski, Alexandra Suwalska and Andrea Pfennig

    Citation: International Journal of Bipolar Disorders 2013 1:11

    Content type: Research

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  30. Despite being present in up to 1% of the population, few controlled trials have examined the efficacy of treatments for bipolar II depression. Pooled data are presented from four placebo-controlled studies (BO...

    Authors: Allan H Young, Joseph R Calabrese, Urban Gustafsson, Michael Berk, Susan L McElroy, Michael E Thase, Trisha Suppes and Willie Earley

    Citation: International Journal of Bipolar Disorders 2013 1:10

    Content type: Research

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  31. In psychiatric literature stretching over a century, there have been glaring discrepancies in the findings describing the relationship between bipolar disorder (BD) and socioeconomic status (SES). Early studie...

    Authors: Laeticia Eid, Katrina Heim, Sarah Doucette, Shannon McCloskey, Anne Duffy and Paul Grof

    Citation: International Journal of Bipolar Disorders 2013 1:9

    Content type: Research

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  32. Most bipolar patients experience a reduction in urinary concentrating ability within a few weeks of starting lithium treatment. This phenomenon may be connected with the effect of lithium on the glycogen synth...

    Authors: Janusz K Rybakowski, Maria Abramowicz, Aleksandra Szczepankiewicz, Michal Michalak, Joanna Hauser and Stanislaw Czekalski

    Citation: International Journal of Bipolar Disorders 2013 1:8

    Content type: Research

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  33. Current screening recommendations for early detection of lithium-associated hyperparathyroidism propose an exclusive measurement of serum albumin-adjusted calcium (Aac) concentration as a single first step. Ho...

    Authors: Michael Berger, Michael Riedel, Nora Tomova, Michael Obermeier, Florian Seemüller, Sandra Dittmann, Hans-Jürgen Moeller and Emanuel Severus

    Citation: International Journal of Bipolar Disorders 2013 1:7

    Content type: Research

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  34. Biological rhythm disturbance is common in bipolar patients and seems to affect the course and prognosis of the illness negatively. The main aim of the current study was to assess biological rhythms in remitte...

    Authors: Adriane R Rosa, Mercè Comes, Carla Torrent, Brisa Solè, Maria Reinares, Isabella Pachiarotti, Manel Salamero, Flávio Kapczinski, Francesc Colom and Eduard Vieta

    Citation: International Journal of Bipolar Disorders 2013 1:6

    Content type: Research

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  35. The objective of this study is to investigate drug treatment patterns in bipolar disorder using daily data from patients who received treatment as usual.

    Authors: Michael Bauer, Tasha Glenn, Martin Alda, Kemal Sagduyu, Wendy Marsh, Paul Grof, Rodrigo Munoz, Emanuel Severus, Philipp Ritter and Peter C Whybrow

    Citation: International Journal of Bipolar Disorders 2013 1:5

    Content type: Research

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  36. This study aims to evaluate the effectiveness of aripiprazole augmentation of maintenance treatment for bipolar disorder in patients with minor or subsyndromal mood episodes while on a stable dose of a mood st...

    Authors: Isaac Schweitzer, Jerome Sarris, Virginia Tuckwell, Kay Maguire, Deidre Smith and Chee Ng

    Citation: International Journal of Bipolar Disorders 2013 1:4

    Content type: Research

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  37. People in midlife with established psychosis or bipolar disorder exhibit patterns of cortical thinning across several brain regions. It is unclear whether these patterns are indicative of a continuously active...

    Authors: Sean N Hatton, Jim Lagopoulos, Daniel F Hermens, Elizabeth Scott, Ian B Hickie and Maxwell R Bennett

    Citation: International Journal of Bipolar Disorders 2013 1:3

    Content type: Research

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  38. Bipolar disorders rank as one of the most disabling illnesses in working age adults worldwide. Despite this, the quality of care offered to patients with this disorder is suboptimal, largely due to limitations...

    Authors: Chantal Henry, Ole A Andreassen, Angelo Barbato, Jacques Demotes-Mainard, Guy Goodwin, Marion Leboyer, Eduard Vieta, Willem A Nolen, Lars Vedel Kessing, Jan Scott and Michael Bauer

    Citation: International Journal of Bipolar Disorders 2013 1:2

    Content type: Review

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