Articles

Cognitive impairments and predominant polarity in bipolar disorder: a cross-sectional study

Bipolar disorder (BD) patients exhibit cognitive impairments during euthymic states. Studies suggest that manic episodes may be correlated to cognitive impairments. The present study investigated the relations...

Authors: Gabriel Okawa Belizario, Alexandre Duarte Gigante, Cristiana Castanho de Almeida Rocca and Beny Lafer

Lithium in the episode and suicide prophylaxis and in augmenting strategies in patients with unipolar depression

Depressive disorders are a leading cause of the global burden of disease and are associated with high recurrent often continuing morbidity and high excess mortality by suicide and cardiovascular disease. Whils...

Authors: Mohammed T. Abou-Saleh, Bruno Müller-Oerlinghausen and Alec J. Coppen

Self-poisoning suicide deaths in people with bipolar disorder: characterizing a subgroup and identifying treatment patterns

To characterize self-poisoning suicide deaths in BD compared to other suicide decedents.

Authors: Ayal Schaffer, Lauren M. Weinstock, Mark Sinyor, Catherine Reis, Benjamin I. Goldstein, Lakshmi N. Yatham and Anthony J. Levitt

Cognitive remediation for bipolar patients with objective cognitive impairment: a naturalistic study

Many bipolar patients (BP) are affected by cognitive impairments and reduced psychosocial function even after complete remission. In the present naturalistic study, we developed a tailored cognitive remediatio...

Authors: J. Veeh, J. Kopf, S. Kittel-Schneider, J. Deckert and A. Reif

Prodrome or risk syndrome: what’s in a name?

In the last decade, an increasing number of publications have examined the precursors of bipolar disorders (BD) and attempted to clarify the early origins and illness trajectory. This is a complex task as the...

Authors: Pierre Alexis Geoffroy and Jan Scott

Erratum to: Online information seeking by patients with bipolar disorder: results from an international multisite survey

Authors: Jörn Conell, Rita Bauer, Tasha Glenn, Martin Alda, Raffaella Ardau, Bernhard T. Baune, Michael Berk, Yuly Bersudsky, Amy Bilderbeck, Alberto Bocchetta, Letizia Bossini, Angela Marianne Paredes Castro, Eric Yat Wo Cheung, Caterina Chillotti, Sabine Choppin, Maria Del Zompo…

Poor quality of life and functioning in bipolar disorder

This study explores the association of demographic and clinical features with quality of life and functioning in individuals with bipolar disorder.

Authors: Louisa G. Sylvia, Rebecca E. Montana, Thilo Deckersbach, Michael E. Thase, Maurcio Tohen, Noreen Reilly-Harrington, Melvin G. McInnis, James H. Kocsis, Charles Bowden, Joseph Calabrese, Keming Gao, Terence Ketter, Richard C. Shelton, Susan L. McElroy, Edward S. Friedman, Dustin J. Rabideau…

Use of physical restraints among patients with bipolar disorder in Ethiopian Mental Specialized Hospital, outpatient department: cross-sectional study

Even though United Nation announced that all persons with a mental illness shall be treated with humanity and respect for the inherent dignity of the human being, up to now, the use of coercion (physical restr...

Authors: Habte Belete

Long-term use of lurasidone in patients with bipolar disorder: safety and effectiveness over 2 years of treatment

Bipolar disorder is a chronic illness with a 2-year recurrence rate of approximately 50% among individuals receiving treatment in the community. The aim of this 18-month, open-label, continuation study was to ...

Authors: Andrei Pikalov, Joyce Tsai, Yongcai Mao, Robert Silva, Josephine Cucchiaro and Antony Loebel

A pilot study to determine whether combinations of objectively measured activity parameters can be used to differentiate between mixed states, mania, and bipolar depression

Until recently, actigraphy studies in bipolar disorders focused on sleep rather than daytime activity in mania or depression, and have failed to analyse mixed episodes separately. Furthermore, even those studi...

Authors: Jan Scott, Arne E. Vaaler, Ole Bernt Fasmer, Gunnar Morken and Karoline Krane-Gartiser

Pilot study of a culturally adapted psychoeducation (CaPE) intervention for bipolar disorder in Pakistan

Despite the use of maintenance medication, recurrence rates in bipolar affective disorder (BPAD) are high. To date, there are no clinical trials that have investigated the use of psychological interventions i...

Authors: Muhammad Ishrat Husain, Imran B. Chaudhry, Raza R. Rahman, Munir M. Hamirani, Nasir Mehmood, Peter M. Haddad, John Hodsoll, Allan H. Young, Farooq Naeem and Nusrat Husain

Ethical perspectives on recommending digital technology for patients with mental illness

The digital revolution in medicine not only offers exciting new directions for the treatment of mental illness, but also presents challenges to patient privacy and security. Changes in medicine are part of the...

Authors: Michael Bauer, Tasha Glenn, Scott Monteith, Rita Bauer, Peter C. Whybrow and John Geddes

A systematic review of the frequency and severity of manic symptoms reported in studies that compare phenomenology across children, adolescents and adults with bipolar disorders

In the last two decades, there has been a significant increase in the diagnosis of Bipolar Disorder (BD) in children. The notion of prepubertal onsets of BD is not without controversy, with researchers debatin...

Authors: Faye Ryles, Thomas D. Meyer, Jaime Adan-Manes, Iain MacMillan and Jan Scott

American tertiary clinic-referred bipolar II disorder versus bipolar I disorder associated with hastened depressive recurrence

Bipolar disorder (BD) is a chronic, frequently comorbid condition characterized by high rates of mood episode recurrence and suicidality. Little is known about prospective longitudinal characterization of BD ...

Authors: Bernardo Dell’Osso, Saloni Shah, Dennis Do, Laura D. Yuen, Farnaz Hooshmand, Po W. Wang, Shefali Miller and Terence A. Ketter

The seroprevalence of antithyroid peroxidase antibodies in bipolar families and bipolar twins: results from two longitudinal studies

Previous studies of our group among bipolar offspring and bipolar twins showed significant higher prevalence’s and levels of antithyroid peroxidase antibodies (TPO-Abs) in offspring and co-twins (without a moo...

Authors: G. Snijders, L. de Witte, E. Mesman, S. Kemner, R. Vonk, R. Brouwer, W. A. Nolen, H. A. Drexhage and M. H. J. Hillegers

Lithium side effects and toxicity: prevalence and management strategies

Despite its virtually universal acceptance as the gold standard in treating bipolar disorder, prescription rates for lithium have been decreasing recently. Although this observation is multifactorial, one obvi...

Authors: Michael Gitlin

Serum concentrations of mood stabilizers are associated with memory, but not other cognitive domains in psychosis spectrum disorders; explorative analyses in a naturalistic setting

Mood stabilizers like lithium and anticonvulsants are used in bipolar and related psychotic disorders. There is a lack of knowledge of the relationship of these medications and cognition in the psychosis spect...

Authors: Nils Eiel Steen, Monica Aas, Carmen Simonsen, Ingrid Dieset, Martin Tesli, Mari Nerhus, Erlend Gardsjord, Ragni Mørch, Ingrid Agartz, Ingrid Melle, Anja Vaskinn, Olav Spigset and Ole A. Andreassen

Electronic monitoring of self-reported mood: the return of the subjective?

This narrative review describes recent developments in the use of technology for utilizing the self-monitoring of mood, provides some relevant background, and suggests some promising directions. Subjective exp...

Authors: Abigail Ortiz and Paul Grof

Aims and structure of the German Research Consortium BipoLife for the study of bipolar disorder

Bipolar disorder is a severe and heterogeneous mental disorder. Despite great advances in neuroscience over the past decades, the precise causative mechanisms at the transmitter, cellular or network level have...

Authors: Philipp S. Ritter, Felix Bermpohl, Oliver Gruber, Martin Hautzinger, Andreas Jansen, Georg Juckel, Tilo Kircher, Martin Lambert, Christoph Mulert, Andrea Pfennig, Andreas Reif, Otto Rienhoff, Thomas G. Schulze, Emanuel Severus, Thomas Stamm and Michael Bauer

Bipolar disorder in the digital age: new tools for the same illness

“Nothing is more difficult than to ascertain the length of time that a maniacal patient can exist without sleep.”—Dr. Sutherland (Br J Psychiatry 7(37):1–19, 1861). Dr. Sutherland’s patient was suffering from an ...

Authors: John Torous, Paul Summergrad and S. Nassir Ghaemi

Bipolar disorder in children and adolescents: diagnostic inpatient rates from 2000 to 2013 in Germany

Despite growing consensus on nosology and epidemiology of bipolar disorder (BD) in minors, differences remain. We contribute to this discussion by measuring long-term trends in the inpatient discharge rates of...

Authors: Pradeep Rao, Julie K. Moore, Richard Stewart, Kevin Runions, Natasha Bear, Janice W. Y. Wong, Martin Holtmann and Florian D. Zepf

Psychometric properties and validation of a four-item version of the Strauss–Carpenter scale in bipolar disorder

Bipolar disorder is a chronic illness that impairs functioning and affects the quality of life of patients. The onset of this illness usually occurs at an early age, and the risk of relapse remains high for de...

Authors: Susana Alberich, Sara Barbeito, Itxaso González-Ortega, Amaia Ugarte, Patricia Vega, Sonia Ruiz de Azúa, Purificación López, Iñaki Zorrilla and Ana González-Pinto

Symptom profiles and illness course among Anabaptist and Non-Anabaptist adults with major mood disorders

Anabaptists comprise large and growing Amish and Mennonite populations with a unique genetic heritage and cultural background. Little is known about the symptoms and course of major mood disorders in Anabaptis...

Authors: Kelly E. Gill, Stephanie A. Cardenas, Layla Kassem, Thomas G. Schulze and Francis J. McMahon

No differences in visual theory of mind abilities between euthymic bipolar patients and healthy controls

Research on theory of mind (ToM) abilities in patients with bipolar disorder has yielded conflicting results. Meta-analyses point to a stable moderate impairment in remitted patients, but factors such as subsy...

Authors: Silvia Haag, Paula Haffner, Esther Quinlivan, Martin Brüne and Thomas Stamm

Is treatment for bipolar disorder more effective earlier in illness course? A comprehensive literature review

We aimed to investigate a key element of the early intervention approach; whether treatment at an earlier stage of bipolar disorder is more effective than later in its course.

Authors: Katie Joyce, Andrew Thompson and Steven Marwaha

Mixed mania associated with cessation of breastfeeding

This case chronicles the unique presentation of psychotic mixed mania in a female 5 months after parturition and 1 week following breastfeeding discontinuation, highlighting a rarely recognized mania risk fact...

Authors: Kristen A. Schmidt, Brian A. Palmer and Mark A. Frye

Online information seeking by patients with bipolar disorder: results from an international multisite survey

Information seeking is an important coping mechanism for dealing with chronic illness. Despite a growing number of mental health websites, there is little understanding of how patients with bipolar disorder us...

Authors: Jörn Conell, Rita Bauer, Tasha Glenn, Martin Alda, Raffaella Ardau, Bernhard T. Baune, Michael Berk, Yuly Bersudsky, Amy Bilderbeck, Alberto Bocchetta, Letizia Bossini, Angela Marianne Paredes Castro, Eric Yat Wo Cheung, Caterina Chillotti, Sabine Choppin, Maria Del Zompo…

Behavioral measures and self-report of impulsivity in bipolar disorder: no association between Stroop test and Barratt Impulsiveness Scale

Impulsivity as a tendency to act quickly without considering future consequences has been proposed as a dimensional factor in bipolar disorder. It can be measured using behavioral tasks and self-report questio...

Authors: Elisa Sophie Strasser, Paula Haffner, Jana Fiebig, Esther Quinlivan, Mazda Adli and Thomas Josef Stamm

Current irritability associated with hastened depressive recurrence and delayed depressive recovery in bipolar disorder

Current irritability is associated with greater retrospective and current bipolar disorder (BD) illness severity; less is known about prospective longitudinal implications of current irritability. We examined ...

Authors: Laura D. Yuen, Saloni Shah, Dennis Do, Shefali Miller, Po W. Wang, Farnaz Hooshmand and Terence A. Ketter

Does CRP predict outcome in bipolar disorder in regular outpatient care?

The association between inflammation and the course of mood disorders is receiving increased attention. This study aims to investigate whether a sub-group of patients with BD can be identified for which a high...

Authors: Sonya M. Balukova, Bartholomeus C. M. Haarman, Rixt F. Riemersma-van der Lek and Robert A. Schoevers

Bipolar disorder and diabetes mellitus: evidence for disease-modifying effects and treatment implications

Bipolar disorder refers to a group of chronic psychiatric disorders of mood and energy levels. While dramatic psychiatric symptoms dominate the acute phase of the diseases, the chronic course is often determin...

Authors: Ellen F. Charles, Christophe G. Lambert and Berit Kerner

Repeated salivary daytime cortisol and onset of mood episodes in offspring of bipolar parents

Differences in cortisol secretion may differentiate individuals at high compared to low genetic risk for bipolar disorder (BD) and predict the onset or recurrence of mood episodes. The objectives of this study...

Authors: Sarah M. Goodday, Julie Horrocks, Charles Keown-Stoneman, Paul Grof and Anne Duffy

Toxoplasma gondii exposure may modulate the influence of TLR2 genetic variation on bipolar disorder: a gene–environment interaction study

Genetic vulnerability to environmental stressors is yet to be clarified in bipolar disorder (BD), a complex multisystem disorder in which immune dysfunction and infectious insults seem to play a major role in ...

Authors: José Oliveira, Rémi Kazma, Edith Le Floch, Meriem Bennabi, Nora Hamdani, Djaouida Bengoufa, Mehdi Dahoun, Céline Manier, Frank Bellivier, Rajagopal Krishnamoorthy, Jean-François Deleuze, Robert Yolken, Marion Leboyer and Ryad Tamouza

Big data for bipolar disorder

The delivery of psychiatric care is changing with a new emphasis on integrated care, preventative measures, population health, and the biological basis of disease. Fundamental to this transformation are big da...

Authors: Scott Monteith, Tasha Glenn, John Geddes, Peter C. Whybrow and Michael Bauer

Biological rhythms are independently associated with quality of life in bipolar disorder

Evidence suggests that patients with bipolar disorder (BD) experience biological rhythm disturbances; however, no studies have examined the impact of this disruption on quality of life (QOL). The aim of this s...

Authors: Lauren E. Cudney, Benicio N. Frey, David L. Streiner, Luciano Minuzzi and Roberto B. Sassi

The direct and indirect effects of lurasidone monotherapy on functional improvement among patients with bipolar depression: results from a randomized placebo-controlled trial

Bipolar depression is characterized by depressive symptoms and impairment in many areas of functioning, including work, family, and social life. The objective of this study was to assess the independent, direc...

Authors: Krithika Rajagopalan, Elizabeth Dansie Bacci, Kathleen W. Wyrwich, Andrei Pikalov and Antony Loebel

Development and validation of the BD S_X: a brief measure of mood and symptom variability for use with adults with bipolar disorder

Ecological momentary sampling in BD research requires brief symptom measures with low cognitive demands to maximize data collection across the range of BD symptomatology. We developed the BD S_x cognizant of the c...

Authors: Norm O’Rourke, Andrew Sixsmith, David B. King, Hamed Yaghoubi-Shahir and Sarah L. Canham

Behavioral and emotional adverse events of drugs frequently used in the treatment of bipolar disorders: clinical and theoretical implications

Behavioral and emotional adverse events induced by drugs commonly prescribed to patients with bipolar disorders are of paramount importance to clinical practice and research. However, no reviews on the topic h...

Authors: Alejandro Szmulewicz, Cecilia Samamé, Pablo Caravotta, Diego J. Martino, Ana Igoa, Diego Hidalgo-Mazzei, Francesc Colom and Sergio A. Strejilevich

Bipolar disorder and antithyroid antibodies: review and case series

Mood disorders and circulating thyroid antibodies are very prevalent in the population and their concomitant occurrence may be due to chance. However, thyroid antibodies have been repeatedly hypothesized to p...

Authors: Alberto Bocchetta, Francesco Traccis, Enrica Mosca, Alessandra Serra, Giorgio Tamburini and Andrea Loviselli

Harnessing the potential of community-based participatory research approaches in bipolar disorder

Despite the rapid growth in the sophistication of research on bipolar disorder (BD), the field faces challenges in improving quality of life (QoL) and symptom outcomes, adapting treatments for marginalized com...

Authors: Erin E. Michalak, Steven Jones, Fiona Lobban, Guillermo Perez Algorta, Steven J. Barnes, Lesley Berk, Michael Berk, Rachelle Hole, Sara Lapsley, Victoria Maxwell, Roumen Milev, John McManamy, Greg Murray, Mauricio Tohen, Samson Tse, Manuel Sanchez de Carmona…

Circadian rhythmicity in emerging mood disorders: state or trait marker?

Circadian rhythm disturbances overlap with the symptoms of mood episodes and may trigger or prolong mood symptoms. There is limited research on the role of circadian disturbances in mood disorders in young peo...

Authors: Ashlee B. Grierson, Ian B. Hickie, Sharon L. Naismith, Daniel F. Hermens, Elizabeth M. Scott and Jan Scott

The role of childhood trauma in bipolar disorders

This review will discuss the role of childhood trauma in bipolar disorders. Relevant studies were identified via Medline (PubMed) and PsycINFO databases published up to and including July 2015. This review con...

Authors: Monica Aas, Chantal Henry, Ole A. Andreassen, Frank Bellivier, Ingrid Melle and Bruno Etain

Lithium overdosage and related tests

Lithium acts biochemically through the inositol depletion in brain cortex. At low doses, however, it is partly effective and/or ineffective, whereas in high concentrations is toxic. We would like to make one p...

Authors: Paolo D. Pigatto, Bernardo Dell’Osso and Gianpaolo Guzzi

Will mania survive DSM-5 and ICD-11?

As a natural phenomenon, mania without major depression will of course survive DSM-5 and ICD-11, but following its integration as a diagnosis into bipolar-I disorder (BP-I) in those manuals, BP-I will be more ...

Authors: Jules Angst

Treatment of lithium intoxication: facing the need for evidence

Lithium has been used as the gold standard in the treatment of major depressive and bipolar disorders for decades. Due to its narrow therapeutic index, lithium toxicity is a common clinical problem. Although r...

Authors: R. Haussmann, M. Bauer, S. von Bonin, P. Grof and U. Lewitzka

Low self-recognition and awareness of past hypomanic and manic episodes in the general population

Bipolar disorder is often underdiagnosed and undertreated. Its detection and correct diagnosis highly relies on the report of past hypomanic or manic episodes. We investigated the recognition and awareness of ...

Authors: Eline J. Regeer, Ralph W. Kupka, Margreet ten Have, Wilma Vollebergh and Willem A. Nolen

Big data are coming to psychiatry: a general introduction

Big data are coming to the study of bipolar disorder and all of psychiatry. Data are coming from providers and payers (including EMR, imaging, insurance claims and pharmacy data), from omics (genomic, proteomi...

Authors: Scott Monteith, Tasha Glenn, John Geddes and Michael Bauer

Inflammatory monocyte gene expression: trait or state marker in bipolar disorder?

This study aimed to examine whether inflammatory gene expression was a trait or a state marker in patients with bipolar disorder (BD).

Authors: K. Becking, B. C. M. Haarman, R. F. Riemersma van der Lek, L. Grosse, W. A. Nolen, S. Claes, H. A. Drexhage and R. A. Schoevers

Do your patients with bipolar disorder use dietary supplements?

Authors: Peter C Whybrow and Tasha Glenn

Randomized, placebo-controlled, adjunctive study of armodafinil for bipolar I depression: implications of novel drug design and heterogeneity of concurrent bipolar maintenance treatments

Some, but not all, prior investigations suggest armodafinil may have utility as an adjunctive treatment in bipolar I depression.

Authors: Mark A Frye, Jess Amchin, Michael Bauer, Caleb Adler, Ronghua Yang and Terence A Ketter