Articles

Glial-specific gene alterations associated with manic behaviors

Glial dysfunction has been purported to be important to the pathophysiology of bipolar illness. However, manic behavior has not been previously demonstrated to result as a consequence of glial pathology. The a...

Authors: Yonglin Gao, Malhar Jhaveri, Zhenmin Lei, Brandy L Chaneb, Jerry Lingrel and Rif S El-Mallakh

The common bipolar phenotype in young people

Mood elevation is common in adolescents and young adults. The aim of this study was to investigate the prevalence of a bipolar diagnosis and co-morbidity in individuals identified by online screening for exper...

Authors: Philippa L Rock, Rebecca A Chandler, Catherine J Harmer, Robert D Rogers and Guy M Goodwin

Hypercalcemia in patients with bipolar disorder treated with lithium: a cross-sectional study

Lithium-induced hyperparathyroidism (LIH) is a relative underrecognized complication of long-term lithium treatment. Hypercalcemia may be the first, but often overlooked, sign of LIH. Symptoms of LIH can be si...

Authors: Bas A Twigt, Bernard M Houweling, Menno R Vriens, Eline J Regeer, Ralph W Kupka, Inne HM Borel Rinkes and Gerlof D Valk

Sleep quality during euthymia in bipolar disorder: the role of clinical features, personality traits, and stressful life events

Poor sleep quality is known to precede the onset of mood episodes and to be associated with poor treatment outcomes in bipolar disorder (BD). We sought to identify modifiable factors that correlate with poor s...

Authors: Erika FH Saunders, Danielle M Novick, Julio Fernandez-Mendoza, Masoud Kamali, Kelly A Ryan, Scott A Langenecker, Alan J Gelenberg and Melvin G McInnis

Bipolar disorder with comorbid anxiety disorders: impact of comorbidity on treatment outcome in cognitive-behavioral therapy and psychoeducation

Comorbid anxiety disorders are extremely prevalent in bipolar disorder (BD) and have substantial impact on the course of illness. Limited evidence regarding treatment factors has led to a renewal of research e...

Authors: Lisa D Hawke, Vytas Velyvis and Sagar V Parikh

Diagnosing bipolar disorders in DSM-5

Authors: Emanuel Severus and Michael Bauer

Bipolar disorders in DSM-5: strengths, problems and perspectives

The diagnostic classification of mood disorders by the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR) had two major shortcomings: an underdiagnosis of bipolar disorders and a large proportion o...

Authors: Jules Angst

Impulsivity, anxiety, and alcohol misuse in bipolar disorder comorbid with eating disorders

Eating disorders (ED) are noted to occur with bipolar disorder (BD), but relationships between additional comorbidities, clinical correlates, and personality factors common to both remain largely unknown.

Authors: Andrew Jen, Erika FH Saunders, Rollyn M Ornstein, Masoud Kamali and Melvin G McInnis

Stability of lithium treatment in bipolar disorder - long-term follow-up of 346 patients

The purpose of this study was to investigate the effectiveness and stability of long-term lithium treatment in a prospective, international, multicenter cohort of bipolar patients in a naturalistic setting.

Authors: Anne Berghöfer, Martin Alda, Mazda Adli, Christopher Baethge, Michael Bauer, Tom Bschor, Paul Grof, Bruno Müller-Oerlinghausen, Janusz K Rybakowski, Alexandra Suwalska and Andrea Pfennig

Quetiapine monotherapy in bipolar II depression: combined data from four large, randomized studies

Despite being present in up to 1% of the population, few controlled trials have examined the efficacy of treatments for bipolar II depression. Pooled data are presented from four placebo-controlled studies (BO...

Authors: Allan H Young, Joseph R Calabrese, Urban Gustafsson, Michael Berk, Susan L McElroy, Michael E Thase, Trisha Suppes and Willie Earley

Bipolar disorder and socioeconomic status: what is the nature of this relationship?

In psychiatric literature stretching over a century, there have been glaring discrepancies in the findings describing the relationship between bipolar disorder (BD) and socioeconomic status (SES). Early studie...

Authors: Laeticia Eid, Katrina Heim, Sarah Doucette, Shannon McCloskey, Anne Duffy and Paul Grof

The association of glycogen synthase kinase-3beta (GSK-3β) gene polymorphism with kidney function in long-term lithium-treated bipolar patients

Most bipolar patients experience a reduction in urinary concentrating ability within a few weeks of starting lithium treatment. This phenomenon may be connected with the effect of lithium on the glycogen synth...

Authors: Janusz K Rybakowski, Maria Abramowicz, Aleksandra Szczepankiewicz, Michal Michalak, Joanna Hauser and Stanislaw Czekalski

Do current screening recommendations allow for early detection of lithium-induced hyperparathyroidism in patients with bipolar disorder?

Current screening recommendations for early detection of lithium-associated hyperparathyroidism propose an exclusive measurement of serum albumin-adjusted calcium (Aac) concentration as a single first step. Ho...

Authors: Michael Berger, Michael Riedel, Nora Tomova, Michael Obermeier, Florian Seemüller, Sandra Dittmann, Hans-Jürgen Moeller and Emanuel Severus

Biological rhythm disturbance in remitted bipolar patients

Biological rhythm disturbance is common in bipolar patients and seems to affect the course and prognosis of the illness negatively. The main aim of the current study was to assess biological rhythms in remitte...

Authors: Adriane R Rosa, Mercè Comes, Carla Torrent, Brisa Solè, Maria Reinares, Isabella Pachiarotti, Manel Salamero, Flávio Kapczinski, Francesc Colom and Eduard Vieta

Drug treatment patterns in bipolar disorder: analysis of long-term self-reported data

The objective of this study is to investigate drug treatment patterns in bipolar disorder using daily data from patients who received treatment as usual.

Authors: Michael Bauer, Tasha Glenn, Martin Alda, Kemal Sagduyu, Wendy Marsh, Paul Grof, Rodrigo Munoz, Emanuel Severus, Philipp Ritter and Peter C Whybrow

Aripiprazole as augmentation therapy in bipolar patients with current minor or subsyndromal mood symptoms

This study aims to evaluate the effectiveness of aripiprazole augmentation of maintenance treatment for bipolar disorder in patients with minor or subsyndromal mood episodes while on a stable dose of a mood st...

Authors: Isaac Schweitzer, Jerome Sarris, Virginia Tuckwell, Kay Maguire, Deidre Smith and Chee Ng

Cortical thinning in young psychosis and bipolar patients correlate with common neurocognitive deficits

People in midlife with established psychosis or bipolar disorder exhibit patterns of cortical thinning across several brain regions. It is unclear whether these patterns are indicative of a continuously active...

Authors: Sean N Hatton, Jim Lagopoulos, Daniel F Hermens, Elizabeth Scott, Ian B Hickie and Maxwell R Bennett

European Network of Bipolar Research Expert Centre (ENBREC): a network to foster research and promote innovative care

Bipolar disorders rank as one of the most disabling illnesses in working age adults worldwide. Despite this, the quality of care offered to patients with this disorder is suboptimal, largely due to limitations...

Authors: Chantal Henry, Ole A Andreassen, Angelo Barbato, Jacques Demotes-Mainard, Guy Goodwin, Marion Leboyer, Eduard Vieta, Willem A Nolen, Lars Vedel Kessing, Jan Scott and Michael Bauer

Editorial: a new journal in bipolar disorders

Authors: Michael Bauer