- Open Access
Characterization of affective lability across subgroups of psychosis spectrum disorders
International Journal of Bipolar Disorders volume 9, Article number: 34 (2021)
Affective lability is elevated and associated with increased clinical burden in psychosis spectrum disorders. The extent to which the level, structure and dispersion of affective lability varies between the specific disorders included in the psychosis spectrum is however unclear. To have potential value as a treatment target, further characterization of affective lability in these populations is necessary. The main aim of our study was to investigate differences in the architecture of affective lability in different psychosis spectrum disorders, and if putative differences remained when we controlled for current symptom status.
Affective lability was measured with The Affective Lability Scale Short Form (ALS-SF) in participants with schizophrenia (SZ, n = 76), bipolar I disorder (BD-I, n = 105), bipolar II disorder (BD-II, n = 68) and a mixed psychosis-affective group (MP, n = 48). Multiple analyses of covariance were conducted to compare the ALS-SF total and subdimension scores of the diagnostic groups, correcting for current psychotic, affective and anxiety symptoms, substance use and sex. Double generalized linear models were performed to compare the dispersion of affective lability in the different groups.
Overall group differences in affective lability remained significant after adjusting for covariates (p = .001). BD-II had higher affective lability compared to SZ and BD-I (p = .004), with no significant differences between SZ and BD-I. There were no significant differences in the contributions of ALS-SF dimensions to the total affective lability or in dispersion of affective lability between the groups.
This study provides the construct of affective lability in psychosis spectrum disorders with more granular details that may have implications for research and clinical care. It demonstrates that despite overlap in core symptom profiles, BD-I is more similar to SZ than it is to BD-II concerning affective lability and the BD groups should consequently be studied apart. Further, affective lability appears to be characterized by fluctuations between depressive- and other affective states across different psychosis spectrum disorders, indicating that affective lability may be related to internalizing problems in these disorders. Finally, although the level varies between groups, affective lability is evenly spread and not driven by extremes across psychosis spectrum disorders and should be assessed irrespective of diagnosis.
Affective lability, the propensity to experience rapid, unpredictable and excessive changes in affective states (Zwicker et al. 2019), is a central and common feature of affective instability that is associated with negative outcomes across psychiatric disorders (Patel et al. 2015; Marwaha et al. 2013a, 2014a, 2018; Broome et al. 2015a,b; McDonald et al. 2020). As a consequence, affective lability and other elements of affective instability are gradually becoming recognized as dimensional and transdiagnostic constructs in line with the Research Domain Criteria (RDoC) project of The National Institute of Mental Health (NIMH) (Broome et al. 2015b; Insel et al. 2010; Fernandez et al. 2016).
Due to the considerable overlap in the symptomatology and etiology of schizophrenia and bipolar disorder, the Kraepelinian dichotomy is increasingly being questioned (Craddock and Owen 2010; Pearlson 2015). Consequently, investigating the full spectrum of these disorders—referred to as psychosis spectrum disorders—is recommended when exploring both biomarkers and clinical features (Guloksuz and Os 2018). Still, studies investigating affective lability thus far have focused on bipolar disorder (BD), which is likely to be due to the fluctuations in affective states inherently tied to a BD diagnosis. Affective lability has been found to be both a trait- and a state-dependent factor in individuals with bipolar I (BD-I) and bipolar II (BD-II) disorders. It is present in periods of euthymia (Henry et al. 2008), early in the course of illness (Aminoff et al. 2012), in all polarities of the illness episodes (Henry et al. 2003; Gershon and Eidelman 2015; Faurholt-Jepsen et al. 2015; Verdolini et al. 2019), as well as in non-affected relatives (Hafeman et al. 2016; Birmaher et al. 2013). Due to its associations with adverse clinical correlates such as alcohol use disorders (AUD) (Lagerberg et al. 2017), suicidality (Aas et al. 2017; Ducasse et al. 2017), anxiety disorders (Aas et al. 2017), cardiometabolic risk (Dargel et al. 2018) and inflammation (Dargel et al. 2017), there is mounting evidence that affective lability may be a relevant therapeutic target in BD.
In schizophrenia (SZ), there has previously been limited emphasis on the prevalence and correlates of affective lability, despite indications that it can be a prominent facet of psychotic experiences (Patel et al. 2015; Marwaha et al. 2014b). Indeed, in our recently published study investigating affective lability across psychotic disorders, we found that affective lability was markedly elevated in individuals with SZ and BD compared to healthy controls, with equally high elevations in both groups (Høegh et al. 2020). Also, affective lability was significantly and independently associated with higher levels of positive psychotic- and depressive symptoms in SZ, and with higher levels of AUD and depressive symptoms in BD. This suggests that affective lability adds to the total illness burden across psychosis spectrum disorders. The findings highlight that increased awareness of affective lability in both research and clinical care is warranted.
To further elucidate the mechanisms of affective lability and its potential value as a treatment target consistent with personalized approaches to psychiatry, it is of interest to explore how and if affective lability varies between the specific disorders included in the psychosis spectrum. In line with this, a few previous studies with relatively small samples, as well as two larger studies, have found higher affective lability in individuals with BD-II compared with BD-I (Faurholt-Jepsen et al. 2015, 2019; O'Donnell et al. 2018; Marwaha et al. 2016). Knowledge about the expression of affective lability in SZ and how this expression overlaps with the broader psychosis spectrum, however, is scarce. Also, it is unclear if there are certain types of lability in affect that are more prominent in the different psychosis spectrum disorders. The presence of anxiety, for example, has been found to be high in both individuals with BD and SZ (Karpov et al. 2016; Achim et al. 2011), but to which extent it is part of the composition of affective lability in the various disorders is not known. For potential intervention efforts to be as targeted as possible, more precise knowledge about which affects that appear to be involved in the lability in the different diagnostic subgroups is needed.
Using the same sample as in our previous study (Høegh et al. 2020) together with newly added participants, we are now able to further explore affective lability measured by The Affective Lability Scale Short Form (ALS-SF) across specific psychosis spectrum disorders. These include SZ, BD-I, BD-II in addition to a mixed “psychosis-affective” (MP) group including schizoaffective disorder and psychotic disorders not otherwise specified (psychosis NOS) with prominent mood symptoms. Here, we aim to investigate if these groups exhibit differences in the architecture of affective lability that could aid further characterization of this phenomenon in psychosis spectrum disorders. We also aim to investigate whether putative differences in affective lability between the diagnostic groups are primarily mediated by differences in their current symptomatology. Finally, we explore potential variations in affective lability within the diagnostic categories in the psychosis spectrum, i.e. between individuals with the same type of disorder, by examining the within-group dispersion of ALS-SF scores, and whether this differs between the diagnostic groups. Such an investigation has, to our knowledge, yet to be conducted in this population and will highlight whether affective lability appears to be driven by subgroups with extreme scores or is more evenly spread within and across the different diagnostic groups.
Accordingly, we seek to investigate affective lability in four diagnostic groups within the psychosis spectrum: SZ, BD-I, BD-II and MP, and more specifically to:
Investigate (a) if there are differences in the total- and subdimension scores of ALS-SF between the groups, (b) if potential differences remain after controlling for current symptoms, and (c) which of the ALS-SF subdimensions contribute most to the total affective lability score in each of the diagnostic groups.
Investigate the dispersion of the ALS-SF scores within each diagnostic category and if there are differences in dispersion between the diagnostic groups.
Material and methods
The current study is part of the larger Thematically Organized Psychosis (TOP) study at the Norwegian Center for Mental Disorders Research (NORMENT) in Oslo, Norway. Recruitment to the TOP study has been ongoing since 2003 and potential participants are referred via psychiatric inpatient and outpatient units, including specialized psychosis units as well as community teams, in a catchment area that is comprised of all the major hospitals in Oslo. As such, the overall representability of the sample is considered to be very good. The participants are given thorough information about the voluntary nature of the study and the possibility to withdraw at any time. The participants included in the study have to meet diagnostic criteria for a Diagnostic and Statistical Manual of Mental Disorders 4th Edition (DSM-IV) diagnosis of schizophrenia- or bipolar spectrum disorder and provide informed consent. Both individuals with established diagnoses and individuals who are diagnosed for the first time are included in the study. Further inclusion criteria are intelligence quotient (IQ) above 70, no prior history of severe head trauma and sufficient understanding of a Scandinavian language (Ringen et al. 2008).
The sample for the current study was comprised of two hundred and ninety-seven participants with psychosis spectrum disorders from the TOP study, and only participants who had completed the ALS-SF were included. The ALS-SF was originally introduced in a TOP study sub-protocol for participants with first episode mania, and a few years later included in the main protocol (i.e. to patients with other diagnoses than BD-I). It was mainly presented for participants with low levels of current affective symptoms. The diagnostic grouping in the current study was as follows: SZ (including schizophreniform [n = 14]) n = 76, BD-I n = 105, BD-II = 68 and MP (including psychosis NOS [n = 32] and schizoaffective disorder [n = 16]) n = 48. The rationale for combining psychosis NOS and schizoaffective disorder into one “mixed” group was that these categories typically include patients with both psychotic- and affective symptoms that are diagnostically more heterogeneous than the other groups (Santelmann et al. 2015, 2016; Widing et al. 2020). Of the present sample, n = 222 were used in our previous study investigating affective lability across the psychosis spectrum (Høegh et al. 2020), and are now re-analyzed along with the newly added participants to shed light on putative differences in affective lability between the specific psychotic disorders.
The diagnoses in the study were established by the Structured Clinical Interview for DSM-IV axis I disorders (SCID-1), modules A-E (First et al. 1995) which was carried out by trained medical doctors, psychiatrists or clinical psychologists. In the TOP study, diagnostic reliability is assessed with regular intervals and Cohen’s kappa for diagnosis in the range between 0.92 and 0.99 has been found across different assessment teams. To assess current symptom state, the positive subscale of the Positive and Negative Syndrome Scale [PANSS (Kay et al. 1987)] was used for positive psychotic symptoms, and the depression item (G6) and the anxiety item (G2) in the general scale of the PANSS were used for depressive- and anxiety symptoms, respectively. PANSS G6 and PANSS G2 were chosen because they were the only measures of depression and anxiety that were collected at the same time point as the ALS-SF for all participants. The rating for G6 is based on the answer to one initial question (“how has your mood been in the past week, mostly good or mostly bad?”) followed by 1–11 follow-up questions concerning the extent of the depressive state and its behavioral consequences. For G2, the rating is based on the same algorithm; one initial question (“have you been feeling worried or nervous in the past week?”) and then 1 to 6 follow-up questions depending on the response to the first question. The Young Mania Rating Scale [YMRS (Young et al. 1978)] was used to assess manic symptoms. The Alcohol Use Disorders Identification Test [AUDIT (Saunders et al. 1993)] was used to evaluate the degree of harmful alcohol consumption, and drug related problems were measured with the Drug Use Disorders Identification Test [DUDIT (Berman et al. 2005)]. Duration of illness was estimated based on the age of onset of the first SCID-verified episode of psychosis for SZ and MP, and the first SCID-verified affective episode for BD-I and BD-II.
The Affective Lability Scale Short Form (ALS-SF)
To measure affective lability, we used the ALS-SF (Oliver and Simons 2004). The ALS-SF captures the total level of affective lability reported by an individual, but also subdimensions of affective lability covering oscillations between three subdomains: anxiety-depression, depression-elation and anger and normal mood. Thus, the scale provides an indication of whether affective lability is predominantly driven by specific- or a combination of affects. The ALS-SF has been found to have good psychometric properties (Aas et al. 2015; Look et al. 2010) and is widely used across different clinical populations. The 18 items of the scale are rated on a four-point Likert scale ranging from 0 (“very uncharacteristic of me”) to 3 (“very characteristic of me”) and yields a total score of affective lability as well as scores for the three subdomains. There are no validated cut-off scores for evaluating the severity of affective lability, but in our previous study we found mean ALS-SF total and subscale scores in the range of 0.17–0.39 for healthy controls, 0.85–1.33 for individuals with BD, and 0.69–1.34 for individuals with SZ (Høegh et al. 2020). This corresponds well with what has been found in at least one similar study (Marwaha et al. 2018).
Descriptive statistics, including means with standard deviations or frequencies with percentages where relevant, were used to investigate demographical and clinical characteristics of the different diagnostic groups. The groups were then compared using one-way between-groups analyses of variance (ANOVA) and chi-square tests. The Tukey’s honestly significant difference (HSD) test was used for post-hoc comparisons where appropriate. To investigate group differences in the level of affective lability as measured by scores on the total- and subdimensions of the ALS-SF, a one-way between-groups multivariate analysis of variance (MANOVA) was conducted with Bonferroni post-hoc tests. A multiple analysis of covariance (MANCOVA) was then carried out to investigate if statistically significant group differences in affective lability remained significant when current symptom and substance use status were entered as covariates. The variables which were significantly associated with diagnostic group and/or with the ALS-SF domains in bivariate correlation analyses were entered as covariates. The selected covariates were as follows: current level of positive psychotic symptoms (PANSS P), manic symptoms (YMRS), depression (PANSS G6), anxiety (PANSS G2), alcohol use (AUDIT) and drug use (DUDIT) (see Table 1 for correlation coefficients). In addition to the symptom and substance use variables, sex was entered as a covariate as there was a significant difference in the number of females in the different groups and previous research has indicated that affective lability is higher in females in general (Marwaha et al. 2013b; Winkler et al. 2004). Age, which has also been found to be associated with affective lability previously (Broome et al. 2015b), was not associated with the diagnostic groups or with the ALS-SF scores in our sample and therefore not included in further analyses. Effect sizes were calculated by partial eta squared. To investigate which of the ALS-SF subdimensions contributed the most to the total affective lability, a one-way repeated measures ANOVA was performed for each group. The Statistical Package for the Social Sciences (SPSS Inc., Chicago, IL, version 26) was used for all statistical analyses and a significance level of p ≤ 0.05 (two-tailed tests) was employed. For aim 2, ALS-SF scores for all dimensions for each diagnostic group were plotted into the Graphpad Prism tool (GraphPad Software, La Jolla California USA, version 8.0 for Windows) and converted into violin plots to illustrate score distributions. To further investigate variability in the ALS-SF scores, double generalized linear models (DGLM, Y ~ Dx, ~ Dx) were carried out using R (R core team 2017) to test if the ALS-SF score dispersions were significantly different between groups (for more detailed information see Additional file 1).
Demographics and clinical characteristics of the sample
Demographic and clinical characteristics for SZ, BD-I, BD-II and MP are presented in Table 2. A statistically significant difference in sex between the groups was found, with fewer women in the SZ group compared to remaining groups. There were also significantly more women in the BD-II compared to the BD-I group. In addition, the duration of illness between the groups was significantly different; the BD-I and BD-II groups had been ill longer than the SZ and MP groups (p < 0.001 and p < 0.05, respectively). Regarding clinical features, there were statistically significant differences between the groups for PANSS total, PANSS P, YMRS, G2 anxiety and AUDIT (see Table 2).
Affective lability in the diagnostic groups: total and subdimension scores
The mean scores for the ALS-SF dimensions for the different diagnostic groups are presented in Fig. 1. The MANOVA showed that there was a statistically significant difference in affective lability between the groups for all of the ALS dimensions: ALS-total F = 8.446, df = 3, p < 0.001; ALS anxiety-depression F = 9.298, df = 3, p < 0.001; ALS depression-elation F = 7.281, p < 0.001 and ALS anger F = 4.252, p = 0.006. Effect sizes were moderate; partial eta2 = 0.080, 0.087, 0.069 and 0.042, respectively.
Post-hoc analyses with Bonferroni revealed that the BD-II group had significantly higher affective lability scores compared to all of the other groups for the ALS total (p < 0.05) and depression-elation (p < 0.05) dimensions. For the ALS anxiety-depression dimension, the scores for the BD-II group were significantly higher than those of the BD-I and SZ groups (p < 0.001 for both), but not the MP group (p = 0.060). Finally, the BD-II group had significantly higher scores compared to the SZ group (p = 0.006) and the MP group (p = 0.042) groups, but not the BD-I group (p = 0.089) on the anger dimension. There were no significant differences in the scores for the SZ and BD-I groups on any dimension (p = 1.000).
Results from multivariate analyses
The overall differences in affective lability between the groups remained statistically significant also after adjusting for the effects of sex, current symptom- and substance use status: ALS total F = 5.305, df = 3, p = 0.001; ALS anxiety-depression F = 6.139, df = 3, p < 001; ALS depression-elation F = 4.432, df = 3, p = 0.005 and ALS anger F = 4.184, df = 3, p = 0.006. Again, the effect sizes were moderate with partial eta2 of 0.057, 0.067, 0.048 and 0.046. Post-hoc group comparisons with Bonferroni showed that the difference in AL between BD-II versus SZ and BD-I remained statistically significant for the ALS total (p = 0.004 for both SZ and BD-I), anxiety-depression (SZ p = 0.038, BD-I p = 0.001) and depression-elation dimensions (SZ p = 0.031, BD-I p = 0.006). The difference between BD-II and SZ on the anger domain also remained statistically significant (p = 0.004). The difference between the MP group and the BD-II group no longer remained statistically significant for the total-, depression-elation- and anger domains after adjusting for covariates.
Contributions of the ALS-SF subdimensions to the total score
In all of the diagnostic groups, the one-way repeated measures ANOVAs with Bonferroni post-hoc tests showed that the anxiety-depression and depression-elation dimensions contributed most to the total affective lability, with no significant differences in the level of scores between these dimensions in any group (p = 1.000 for SZ and BD-I, p = 0.225 for BD-II, p = 0.814 for MP). Across the board, the anger dimension was found to contribute significantly less to the total score compared to the anxiety-depression and depression-elation dimensions (p < 0.001).
Dispersion of affective lability scores within and between the diagnostic groups
The score distributions for all dimensions of the ALS-SF for the four diagnostic groups are shown in Fig. 2a–d. The median score is illustrated by a vertical straight line. The double generalized linear models found no significant differences (p > 0.05) in the score dispersions between any of the groups in any of the domains, indicating that despite differences in mean ALS-SF scores between groups, the dispersion in the scores was the same (for more information see Additional file 1).
The construct of affective lability refers to the propensity to experience rapid, unpredictable and excessive changes in affective states (Zwicker et al. 2019). The main aim of the current study was to investigate differences in affective lability between different psychosis spectrum disorders. Our results show that individuals with BD-II had markedly elevated levels of total- and subdimension affective lability compared to BD-I and SZ, even when correcting for sex, the level of current symptoms and substance use. Affective lability in the MP group, on the other hand, was not significantly different from BD-II nor SZ or BD-I when the covariates were taken into account. There were no statistically significant differences between individuals with BD-I and SZ for any ALS-SF dimension and these two groups had very similar score patterns throughout. This suggests that despite the overlap in core affective symptom profiles of BD-I and BD-II, the BD-I group is more similar to SZ than it is to BD-II concerning levels of affective lability. Further, since we controlled for current symptoms, our findings imply that there are some trait-like differences between the disorders with respect to affective lability, where elevated affective lability is perhaps more inherently tied to BD-II compared to the other psychosis spectrum disorders.
Given that individuals with BD-II are more similar to healthy controls when it comes to neurobiology, genetics and cognition compared to BD-I and SZ (MacQueen et al. 2005), one can speculate if the high affective lability is based in environmental or clinical risk factors specific to BD-II. For instance, childhood trauma has been found to be associated with affective lability (Aas et al. 2014), but the prevalence rates of trauma are reported to be at the same level in individuals with BD-I and BD-II (Palmier-Claus et al. 2016; Janiri et al. 2015). The presence of comorbid Attention-Deficit/Hyperactivity Disorder (ADHD) and anxiety disorders is also likely to increase affective lability (Broome et al. 2015a; Aas et al. 2017), but again the rates are at the same level in BD-I versus BD-II (Pataki and Carlson 2013; Bennett et al. 2019; Brus et al. 2014; Pavlova et al. 2015). It is perhaps more plausible that the elevation in affective lability observed in individuals with BD-II is associated with more frequent and severe borderline personality traits (Saunders et al. 2020) and/or higher rates of depressive episodes and symptoms (Karanti et al. 2020), but this needs to be investigated further. In addition, affective lability, anxiety disorders, borderline personality disorders and BD-II appear to be more prevalent in women compared to men, and there may be some interrelationships here that are worthwhile looking into in future research. Regardless of origin, it seems important to investigate the BD groups separately with regards to affective lability. When it comes to the similarities between individuals with BD-I and SZ, this may not be surprising at least from a genetic point of view, given the established overlap between BD-I and SZ (Tamminga et al. 2013; Tesli et al. 2014). It is, however, important to keep in mind that both individuals with BD-I and SZ also present with higher affective lability rates than healthy controls (Høegh et al. 2020).
With respect to the architecture of affective lability, oscillations between anxiety-depression and depression-elation were the most typical for all groups. In our previous study, we found significant associations between affective lability and current depression in both SZ and BDs (Høegh et al. 2020). We now extend these findings to show that even when controlling for the level of depressive symptoms, significant between-group differences in affective lability persist. Somewhat surprisingly, we found that fluctuations between depression and elation were also prevalent, even in individuals with SZ, along with fluctuations involving anxiety. This is in line with the dimensional perspective of psychosis that has been found in previous research showing a large degree of symptomatic overlap between disorders (Os and Kapur 2009). The mean scores of the SZ, BD-I and MP groups on the anger dimension were low (0.66, 0.79 and 0.69, respectively). Although the anger score for the BD-II group was higher (1.08), it is still comparatively low relative to the BD-II scores for the other dimensions. Collectively, this is an indication that affective lability is related to more internalizing versus externalizing problems and behaviors in psychotic disorders, which is different from the pattern found in for example borderline personality disorder where rapid shifts involving anger appear to be more characteristic (Henry et al. 2001; Koenigsberg et al. 2002).
To our knowledge, the dispersion of ALS-SF scores in the different psychosis spectrum disorders has not previously been investigated. The violin plots showing the full distributions of the data confirm that the scores seem to be relatively evenly dispersed in all groups, i.e. the scores are not clustered around the minimum or maximum but rather around the median score. Hence, the level of affective lability in the groups does not appear to result primarily from the presence of subgroups of patients with extreme scores, but to represent the typical score pattern for each disorder. Visually, the shape of the distribution of scores in the BD-II group stands out, especially for the anxiety-depression dimension. Yet, the statistical analyses revealed no significant differences between the groups with regards to dispersion. This indicates that although the level varies between groups, affective lability is evenly spread and not driven by extremes across psychosis spectrum disorders and should be routinely assessed irrespective of diagnosis.
Limitations and strengths
The present study must be interpreted in light of some limitations. The cross-sectional nature of the study implies that we cannot make causal attributions about the association between diagnostic group and affective lability. In addition, data on comorbid anxiety disorders, personality disorders and ADHD are lacking, and the measures used for anxiety and depressive symptoms are based on a scale primarily developed for assessing psychotic symptoms. Hence, the possibility that current symptoms still could have influenced the association between affective lability and diagnostic group cannot be ruled out completely. However, we believe that the likelihood of this is limited due to the relatively low levels of anxiety and depressive symptoms. Further, the risk of recall- and response bias cannot be ruled out as the ALS-SF is a self-report instrument. The study also has several strengths; it has a large, diagnostically well-characterized sample covering the psychosis spectrum, and uses a multidimensional assessment scale of affective lability that provides a richer insight and understanding of the construct.
Our results illustrate that affective lability is more prominent in individuals with BD-II compared to SZ and BD-I, and that this is not explained by differences between the groups in sex, levels of affective-, psychotic- or anxiety symptoms or severity of substance use. BD-II thus appears to be a particularly vulnerable diagnostic group with respect to affective lability. No differences in affective lability were found between individuals with BD-I and SZ. The results further add information about the structure of affective lability in these disorders emphasizing the significance of fluctuations between depressive- and other affective states. The findings also show that there is an even dispersion of affective lability scores within each diagnostic group, and that the dispersion also appears to be largely equivalent across groups. Overall, the study provides the concept of affective lability in psychotic disorders with more granularity by showing differences and similarities between diagnostic groups that may have implications for both research and clinical practice.
Availability of data and materials
The data that support the findings of this study will be made available upon reasonable request.
Affective Lability Scale Short Form
Research Domain Criteria
The National Institute of Mental Health
Alcohol Use Disorder
Mixed Psychosis group
- Psychosis NOS:
Psychosis Not Otherwise Specified
Thematically Organized Psychosis Study
Norwegian Center for Mental Disorders Research
Diagnostic and Statistical Manual of Mental Disorders 4th Edition
Structured Clinical Interview for DSM-IV
Positive and Negative Syndrome Scale
Young Mania Rating Scale
Alcohol Use Disorders Identification Test
Drug Use Disorders Identification Test
Analysis of Variance
Honestly Significant Difference test
Multivariate Analysis of Variance
Multivariate Analysis of Covariance
Statistical Package for the Social Sciences
Double Generalized Linear Models
Aas M, Aminoff SR, Vik Lagerberg T, Etain B, Agartz I, Andreassen OA, et al. Affective lability in patients with bipolar disorders is associated with high levels of childhood trauma. Psychiatry Res. 2014;218(1–2):252–5.
Aas M, Pedersen G, Henry C, Bjella T, Bellivier F, Leboyer M, et al. Psychometric properties of the affective lability scale (54 and 18-item version) in patients with bipolar disorder, first-degree relatives, and healthy controls. J Affect Disord. 2015;172:375–80.
Aas M, Henry C, Bellivier F, Lajnef M, Gard S, Kahn JP, et al. Affective lability mediates the association between childhood trauma and suicide attempts, mixed episodes and co-morbid anxiety disorders in bipolar disorders. Psychol Med. 2017;47(5):902–12.
Achim AM, Maziade M, Raymond E, Olivier D, Merette C, Roy MA. How prevalent are anxiety disorders in schizophrenia? A meta-analysis and critical review on a significant association. Schizophr Bull. 2011;37(4):811–21.
Aminoff SR, Jensen J, Lagerberg TV, Hellvin T, Sundet K, Andreassen OA, et al. An association between affective lability and executive functioning in bipolar disorder. Psychiatry Res. 2012;198(1):58–61.
Bennett F, Hodgetts S, Close A, Frye M, Grunze H, Keck P, et al. Predictors of psychosocial outcome of bipolar disorder: data from the Stanley Foundation Bipolar Network. Int J Bipolar Disord. 2019;7(1):28.
Berman AH, Bergman H, Palmstierna T, Schlyter F. Evaluation of the drug use disorders identification test (DUDIT) in criminal justice and detoxification settings and in a Swedish population sample. Eur Addict Res. 2005;11(1):22–31.
Birmaher B, Goldstein BI, Axelson DA, Monk K, Hickey MB, Fan J, et al. Mood lability among offspring of parents with bipolar disorder and community controls. Bipolar Disord. 2013;15(3):253–63.
Broome MR, He Z, Iftikhar M, Eyden J, Marwaha S. Neurobiological and behavioural studies of affective instability in clinical populations: a systematic review. Neurosci Biobehav Rev. 2015a;51:243–54.
Broome MR, Saunders KE, Harrison PJ, Marwaha S. Mood instability: significance, definition and measurement. Br J Psychiatry. 2015b;207(4):283–5.
Brus MJ, Solanto MV, Goldberg JF. Adult ADHD vs. bipolar disorder in the DSM-5 era: a challenging differentiation for clinicians. J Psychiatr Pract. 2014;20(6):428–37.
Craddock N, Owen MJ. The Kraepelinian dichotomy—going, going…but still not gone. Br J Psychiatry. 2010;196(2):92–5.
Dargel AA, Godin O, Etain B, Hirakata V, Azorin JM, M’Bailara K, et al. Emotional reactivity, functioning, and C-reactive protein alterations in remitted bipolar patients: clinical relevance of a dimensional approach. Aust N Z J Psychiatry. 2017;51(8):788–98.
Dargel AA, Roussel F, Volant S, Etain B, Grant R, Azorin JM, et al. Emotional hyper-reactivity and cardiometabolic risk in remitted bipolar patients: a machine learning approach. Acta Psychiatr Scand. 2018;138:348.
Ducasse D, Jaussent I, Guillaume S, Azorin JM, Bellivier F, Belzeaux R, et al. Affect lability predicts occurrence of suicidal ideation in bipolar patients: a two-year prospective study. Acta Psychiatr Scand. 2017;135(5):460–9.
Faurholt-Jepsen M, Ritz C, Frost M, Mikkelsen RL, Margrethe Christensen E, Bardram J, et al. Mood instability in bipolar disorder type I versus type II-continuous daily electronic self-monitoring of illness activity using smartphones. J Affect Disord. 2015;186:342–9.
Faurholt-Jepsen M, Frost M, Busk J, Christensen EM, Bardram JE, Vinberg M, et al. Differences in mood instability in patients with bipolar disorder type I and II: a smartphone-based study. Int J Bipolar Disord. 2019;7(1):5.
Fernandez KC, Jazaieri H, Gross JJ. Emotion regulation: a transdiagnostic perspective on a new RDoC domain. Cognit Ther Res. 2016;40(3):426–40.
First MB, Spitzer RL, Gibbon M, Williams JBW. Structured clinical interview for DSM-IV axis I disorders: patient edition (SCID-P), version 2; 1995.
Gershon A, Eidelman P. Inter-episode affective intensity and instability: predictors of depression and functional impairment in bipolar disorder. J Behav Ther Exp Psychiatry. 2015;46:14–8.
Guloksuz S, van Os J. The slow death of the concept of schizophrenia and the painful birth of the psychosis spectrum. Psychol Med. 2018;48(2):229–44.
Hafeman DM, Merranko J, Axelson D, Goldstein BI, Goldstein T, Monk K, et al. Toward the definition of a bipolar prodrome: dimensional predictors of bipolar spectrum disorders in at-risk youths. Am J Psychiatry. 2016;173(7):695–704.
Henry C, Mitropoulou V, New AS, Koenigsberg HW, Silverman J, Siever LJ. Affective instability and impulsivity in borderline personality and bipolar II disorders: similarities and differences. J Psychiatr Res. 2001;35(6):307–12.
Henry C, Swendsen J, Van den Bulke D, Sorbara F, Demotes-Mainard J, Leboyer M. Emotional hyper-reactivity as a fundamental mood characteristic of manic and mixed states. Eur Psychiatry. 2003;18(3):124–8.
Henry C, Van den Bulke D, Bellivier F, Roy I, Swendsen J, M’Bailara K, et al. Affective lability and affect intensity as core dimensions of bipolar disorders during euthymic period. Psychiatry Res. 2008;159(1–2):1–6.
Høegh MC, Melle I, Aminoff SR, Laskemoen JF, Büchmann CB, Ueland T, et al. Affective lability across psychosis spectrum disorders. Eur Psychiatry. 2020;63(1):e53.
Insel T, Cuthbert B, Garvey M, Heinssen R, Pine DS, Quinn K, et al. Research domain criteria (RDoC): toward a new classification framework for research on mental disorders. Am J Psychiatry. 2010;167(7):748–51.
Janiri D, Sani G, Danese E, Simonetti A, Ambrosi E, Angeletti G, et al. Childhood traumatic experiences of patients with bipolar disorder type I and type II. J Affect Disord. 2015;175:92–7.
Karanti A, Kardell M, Joas E, Runeson B, Palsson E, Landen M. Characteristics of bipolar I and II disorder: a study of 8766 individuals. Bipolar Disord. 2020;22(4):392–400.
Karpov B, Joffe G, Aaltonen K, Suvisaari J, Baryshnikov I, Naatanen P, et al. Anxiety symptoms in a major mood and schizophrenia spectrum disorders. Eur Psychiatry. 2016;37:1–7.
Kay SR, Fiszbein A, Opler LA. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull. 1987;13(2):261–76.
Koenigsberg HW, Harvey PD, Mitropoulou V, Schmeidler J, New AS, Goodman M, et al. Characterizing affective instability in borderline personality disorder. Am J Psychiatry. 2002;159(5):784–8.
Lagerberg TV, Aminoff SR, Aas M, Bjella T, Henry C, Leboyer M, et al. Alcohol use disorders are associated with increased affective lability in bipolar disorder. J Affect Disord. 2017;208:316–24.
Look AE, Flory JD, Harvey PD, Siever LJ. Psychometric properties of a short form of the affective lability scale (ALS-18). Pers Individ Dif. 2010;49(3):187–91.
MacQueen GM, Hajek T, Alda M. The phenotypes of bipolar disorder: relevance for genetic investigations. Mol Psychiatry. 2005;10(9):811–26.
Marwaha S, Parsons N, Broome M. Mood instability, mental illness and suicidal ideas: results from a household survey. Soc Psychiatry Psychiatr Epidemiol. 2013a;48(9):1431–7.
Marwaha S, Parsons N, Flanagan S, Broome M. The prevalence and clinical associations of mood instability in adults living in England: results from the adult psychiatric morbidity survey 2007. Psychiatry Res. 2013b;205(3):262–8.
Marwaha S, He Z, Broome M, Singh SP, Scott J, Eyden J, et al. How is affective instability defined and measured? A systematic review. Psychol Med. 2014a;44(9):1793–808.
Marwaha S, Broome MR, Bebbington PE, Kuipers E, Freeman D. Mood instability and psychosis: analyses of British national survey data. Schizophr Bull. 2014b;40(2):269–77.
Marwaha S, Gordon-Smith K, Broome M, Briley PM, Perry A, Forty L, et al. Affective instability, childhood trauma and major affective disorders. J Affect Disord. 2016;190:764–71.
Marwaha S, Price C, Scott J, Weich S, Cairns A, Dale J, et al. Affective instability in those with and without mental disorders: a case control study. J Affect Disord. 2018;241:492–8.
McDonald K, Smith T, Broadbent M, Patel R, Geddes JR, Saunders KEA. Prevalence and incidence of clinical outcomes in patients presenting to secondary mental health care with mood instability and sleep disturbance. Eur Psychiatry. 2020;63(1):e59.
O’Donnell LA, Ellis AJ, Van de Loo MM, Stange JP, Axelson DA, Kowatch RA, et al. Mood instability as a predictor of clinical and functional outcomes in adolescents with bipolar I and bipolar II disorder. J Affect Disord. 2018;236:199–206.
Oliver MNI, Simons JS. The affective lability scales: development of a short-form measure. Pers Indiv Differ. 2004;37(6):1279–88.
Palmier-Claus JE, Berry K, Bucci S, Mansell W, Varese F. Relationship between childhood adversity and bipolar affective disorder: systematic review and meta-analysis. Br J Psychiatry. 2016;209(6):454–9.
Pataki C, Carlson GA. The comorbidity of ADHD and bipolar disorder: any less confusion? Curr Psychiatry Rep. 2013;15(7):372.
Patel R, Lloyd T, Jackson R, Ball M, Shetty H, Broadbent M, et al. Mood instability is a common feature of mental health disorders and is associated with poor clinical outcomes. BMJ Open. 2015;5(5):e007504.
Pavlova B, Perlis RH, Alda M, Uher R. Lifetime prevalence of anxiety disorders in people with bipolar disorder: a systematic review and meta-analysis. Lancet Psychiatry. 2015;2(8):710–7.
Pearlson GD. Etiologic, phenomenologic, and endophenotypic overlap of schizophrenia and bipolar disorder. Annu Rev Clin Psychol. 2015;11(1):251–81.
Ringen PA, Melle I, Birkenaes AB, Engh JA, Faerden A, Jónsdóttir H, et al. Illicit drug use in patients with psychotic disorders compared with that in the general population: a cross-sectional study. Acta Psychiatr Scand. 2008;117(2):133–8.
Santelmann H, Franklin J, Busshoff J, Baethge C. Test-retest reliability of schizoaffective disorder compared with schizophrenia, bipolar disorder, and unipolar depression—a systematic review and meta-analysis. Bipolar Disord. 2015;17(7):753–68.
Santelmann H, Franklin J, Busshoff J, Baethge C. Interrater reliability of schizoaffective disorder compared with schizophrenia, bipolar disorder, and unipolar depression—a systematic review and meta-analysis. Schizophr Res. 2016;176(2–3):357–63.
Saunders JB, Aasland OG, Babor TF, de la Fuente JR, Grant M. Development of the alcohol use disorders identification test (AUDIT): WHO collaborative project on early detection of persons with harmful alcohol consumption-II. Addiction. 1993;88(6):791–804.
Saunders KEA, Jones T, Perry A, Di Florio A, Craddock N, Jones I, et al. The influence of borderline personality traits on clinical outcomes in bipolar disorder. Bipolar Disord. 2020;23:368.
Tamminga CA, Ivleva EI, Keshavan MS, Pearlson GD, Clementz BA, Witte B, et al. Clinical phenotypes of psychosis in the bipolar-schizophrenia network on intermediate phenotypes (B-SNIP). Am J Psychiatry. 2013;170(11):1263–74.
Tesli M, Espeseth T, Bettella F, Mattingsdal M, Aas M, Melle I, et al. Polygenic risk score and the psychosis continuum model. Acta Psychiatr Scand. 2014;130(4):311–7.
Van Os J, Kapur S. Schizophrenia. The Lance. 2009;374(9690):635–45.
Verdolini N, Menculini G, Perugi G, Murru A, Samalin L, Angst J, Azorin JM, Bowden C, Mosolov S, Young AH, Barbuti M, Popovic D, Vieta E, Pacchiarotti I, for the BRIDGE-II-MIX Study Group. Sultans of swing: a reappraisal of the intertwined association between affective lability and mood reactivity in a post hoc analysis of the BRIDGE-II-MIX study. J Clin Psychiatry. 2019;80(2):17m12082.
Widing L, Simonsen C, Flaaten CB, Haatveit B, Vik RK, Wold KF, Åsbø G, Ueland T, Melle I. Symptom profiles in psychotic disorder not otherwise specified. Front Psychiatry. 2020.
Winkler D, Pjrek E, Heiden A, Wiesegger G, Klein N, Konstantinidis A, et al. Gender differences in the psychopathology of depressed inpatients. Eur Arch Psychiatry Clin Neurosci. 2004;254(4):209–14.
Young RC, Biggs JT, Ziegler VE, Meyer DA. A rating scale for mania: reliability, validity and sensitivity. Br J Psychiatry. 1978;133:429–35.
Zwicker A, Drobinin V, MacKenzie LE, Howes Vallis E, Patterson VC, Cumby J, et al. Affective lability in offspring of parents with major depressive disorder, bipolar disorder and schizophrenia. Eur Child Adolesc Psychiatry. 2019;29:445–51.
The authors would like to extend a sincere thank you to all the participants in the TOP study for their time and effort. We would also like to thank everyone at NORMENT.
The study was funded by grants from the Research Council of Norway (#181831, 147787/320, 342#67153/V50 and #288542). The organization had no role in the design of the study, the collection, analysis and interpretation of the data, the writing of the report, or in the decision to submit the paper for publication.
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The TOP study is conducted in line with the Helsinki declaration of 1975 (as revised in 2008 and 2013) and has been approved by the Regional Committee for Medical Research Ethics and the Norwegian Data Inspectorate. All participants must be able to provide informed consent before entering the study.
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Høegh, M.C., Melle, I., Aminoff, S.R. et al. Characterization of affective lability across subgroups of psychosis spectrum disorders. Int J Bipolar Disord 9, 34 (2021). https://doi.org/10.1186/s40345-021-00238-0
- Affective lability
- Bipolar disorders
- Psychosis spectrum
- The Affective Lability Scale-Short Form (ALS-SF)