- Open Access
Sleep quality during euthymia in bipolar disorder: the role of clinical features, personality traits, and stressful life events
International Journal of Bipolar Disordersvolume 1, Article number: 16 (2013)
Poor sleep quality is known to precede the onset of mood episodes and to be associated with poor treatment outcomes in bipolar disorder (BD). We sought to identify modifiable factors that correlate with poor sleep quality in BD independent of residual mood symptoms.
A retrospective analysis was conducted to assess the association between the Pittsburgh Sleep Quality Index and clinical variables of interest in euthymic patients with DSM-IV BD (n = 119) and healthy controls (HC; n = 136) participating in the Prechter Longitudinal Study of Bipolar Disorder. Multivariable linear regression models were constructed to investigate the relationship between sleep quality and demographic and clinical variables in BD and HC participants. A unified model determined independent predictors of sleep quality.
Results and discussion
Euthymic participants with BD and HC differed in all domains. The best fitting unified multivariable model of poor sleep quality in euthymic participants with BD included rapid cycling (β = .20, p = .03), neuroticism (β = .28, p = 2 × 10−3), and stressful life events (β = .20, p = .02). Poor sleep quality often persists during euthymia and can be a target for treatment. Clinicians should remain vigilant for treating subjective sleep complaints independent of residual mood symptoms in those sensitive to poor sleep quality, including individuals with high neuroticism, rapid cycling, and recent stressful life events. Modifiable factors associated with sleep quality should be targeted directly with psychosocial or somatic treatment. Sleep quality may be a useful outcome measure in BD treatment studies.
Bipolar disorder (BD) is a prevalent and chronic psychiatric disorder that is marked by significant impairment in cognitive functioning and impaired quality of life, even during euthymic well intervals (Merikangas et al. 2007; Pattanayak et al. 2012; Ryan et al. 2012; Langenecker et al. 2010; Marshall et al. 2012). For many people with BD, sleep is persistently disrupted, and poor sleep quality is known to precede the onset of both first and recurrent mood episodes (Gruber et al. 2011; Eidelman et al. 2010; Harvey et al. 2005; Jones et al. 2005). In the general population, disturbance of sleep is associated with poor functioning, and insomnia with short sleep duration is associated with poor cognitive functioning and risk for cardiovascular and metabolic diseases (Bixler 2009; Fernandez-Mendoza et al. 2010a; Vgontzas et al. 2009a, b, c). Thus, some morbidity and mortality associated with BD may be related to sleep quality.
Sleep disturbances may be both a cause and a consequence of BD (Talbot et al. 2012; Harvey 2008). Evidence of alterations in the circadian rhythm system comes from genetic and animal models of bipolar disorder (Benedetti et al. 2003, 2007, 2011). Evidence-based somatic treatments (e.g., lithium, melatonin, bright light therapy) and adjunctive psychosocial treatments (e.g., interpersonal social rhythm therapy, behavioral activation) for BD are thought to exert their therapeutic effects, in part, by directly or indirectly shifting, resetting, or stabilizing systems associated with the sleep-wake cycle (Lamont et al. 2007; Frank et al. 2005; McClung 2007).
Little is known about the determinants or correlates of sleep quality during euthymic episodes in BD. In epidemiologic studies of the general population, advancing age, menopausal status, high body mass index (BMI), medical comorbidities, anxiety disorders, stress, and nicotine and substance use are associated with sleep quality (Bixler 2009). In addition, stress and personality factors may play a role in determining sleep quality (Healey et al. 1981; LeBlanc et al. 2007; Marks and Roffwarg 1991; Singareddy et al. 2012; Fernandez-Mendoza et al. 2012a). These factors - aside from advancing age and menopausal status - are generally overrepresented in the BD population (Saunders et al. 2008, 2012; Fagiolini et al. 2002; Swartz and Fagiolini 2012; Prochaska et al. 2011; Dickerson et al. 2013) and thus may be determinants or correlates of sleep quality in the BD population. Against this backdrop, we used data from the baseline visit of the Prechter Longitudinal Study of Bipolar Disorder to understand the effect of clinical features, personality traits, and life events on self-reported sleep quality in a sample of BD subjects who were euthymic and a sample of healthy control (HC) subjects. The Prechter Longitudinal Study is a naturalistic, observational study designed to link detailed clinical assessment of psychiatric and medical history, as well as sleep, stress, environmental factors, substance use, personality, and cognition, to clinical outcomes and genetic and biological data for patients being treated with usual clinical care. We hypothesized that factors in the domains of medical, substance use disorder, and anxiety disorder comorbidities; dimensional/personality traits; life story/trauma; and behavioral domain would show associations with sleep quality in the BD and HC samples similar to those in the general population, and we hypothesized that features of illness in the BD group such as history of suicide attempts, psychosis, mixed episodes, rapid cycling, and high number of episodes would be related to sleep quality.
Our interest in correlates of sleep quality during euthymic episodes in BD is driven by the following questions: Are there modifiable factors that can reliably predict sleep quality and be targeted for treatment, thus reducing the morbidity and mortality associated with poor sleep quality in BD? Can sleep quality be a useful outcome measure in BD treatment studies?
Patients with BD (i.e., bipolar disorder type I, bipolar disorder type II, schizoaffective disorder, bipolar type or bipolar disorder NOS, Table 1) and HCs with no personal or family history of mood or psychotic disorders were recruited to the Prechter Longitudinal Study of Bipolar Disorder at the University of Michigan, an IRB-approved observational study of outcomes in bipolar disorder (IRBMED HUM000606). Participants in the Prechter Longitudinal Study were seen for a baseline assessment described below and followed long-term with self-reported questionnaires and yearly visits.
The clinical sample for this investigation included participants recruited at the University of Michigan between 2005 and 2010, and data were extracted in February 2012. The cohort selected for analysis included euthymic patients with BD (n = 119) and HCs (n = 136) who completed the Pittsburgh Sleep Quality Inventory (PSQI) at baseline. Participants were excluded in the current analysis if they did not have complete data on the PSQI (n = 75) or had baseline depression (Hamilton Depression Rating Scale (HDRS) ≥7, n = 99) or manic/hypomanic/mixed symptoms (Young Mania Rating Scale (YMRS) ≥7, n = 35).
At baseline, clinicians administered the Diagnostic Interview for Genetic Studies (DIGS) (28), HDRS (29), and YMRS (3), and recorded height and weight. The DIGS is a clinician-administered diagnostic interview that includes comprehensive assessment of psychiatric and medical illnesses and includes the ability to assess the lifetime course of mood disorder as well as associated features of mood illness of the individual. Interviewers included physicians, psychologists, and masters-level mental health professionals who completed standardized training in the study instruments, and a best-estimate procedure was used to verify diagnoses (Leckman et al. 1982). Participants completed a baseline set of self-rating questionnaires. Data from the clinical interview and questionnaires were used to assess domains of interest that may relate to sleep quality including sociodemographic factors; clinical features/comorbidities; disease severity; chronotype, sleep, and sleepiness; dimensional/personality traits; life story/trauma history; and behavioral features including substance use (Table 1). Our dependent variable of interest was sleep quality, assessed with the PSQI (Buysse et al. 1989). The PSQI obtains a general measure of sleep quality, and the total score is derived from seven subscales: sleep quality, sleep latency, sleep duration, sleep efficiency, sleep disturbance, sleep medication, and daytime dysfunction. Comparisons of the PSQI subscales were reported between HC and BD groups, and the total PSQI score is used as a dependent variable in analyses. Chronotype was assessed with the Munich Chronotype Questionnaire (MCTQ) (Roenneberg et al. 2003), which assesses preference for sleep and wake times.
Data and statistical analysis
Values of continuous variables were compared between BD and HC groups using two-sample t tests for normally distributed variables or Mann–Whitney U tests for variables with a skewed distribution. Categorical variables were compared using Pearson's chi-square test. Linear regression models were constructed for each continuous variable and logistic regression models for each categorical variable to investigate the difference between groups while adjusting for age, sex, and BMI.
Sleep quality (total PSQI score) was correlated with demographic and clinical variables in each of the HC and BD groups first through the use of bivariate comparisons with Pearson's r for normally distributed variables or Spearman's r for variables that were not normally distributed. To determine independent correlates of poor sleep quality, variables correlated in bivariate comparisons were included in a series of multivariable linear regression models organized by the following domains: sociodemographic factors; clinical features/comorbidities; disease severity; chronotype, sleep, and sleepiness; dimensional/personality traits; life story/trauma history; and behavioral features. Anxiety disorder comorbidity included obsessive-compulsive disorder, panic disorder with or without agoraphobia, social phobia, specific phobia, and agoraphobia without panic. Post-traumatic stress disorder was not included because we did not have a systematic assessment of this disorder. All models at the domain level were adjusted for current depressive symptoms. Final models in each domain were chosen through a backward selection process. Correlates that were independently associated in the domain-wide analyses were selected for a unified multivariable model that was chosen through backward selection.
Demographic description of the sample
The average subject with BD (n = 119) was a 41-year-old, married (44%), employed (70%) female (66%) with a BMI of 29 (Table 2). The average HC (n = 136) was a 32-year-old, not married (74%), employed (84%) female (56%) with a BMI of 25 (Table 2). The age range of the two groups was similar (BD 19 to 65, HC 18 to 66). Approximately one sixth of the HC females had undergone menopause, whereas the rate was one quarter in the BD females. The BD group had significantly more females who were menopausal, had a significantly older group, and a higher BMI. Significantly more BD individuals were married, and significantly more HC were employed or students (Table 2).
Clinical features of HC and BD subjects
Differences in clinical characteristics between HC and BD subjects are summarized in Table 3, both unadjusted and adjusted for age, sex, and BMI (p values reported below are adjusted unless noted otherwise). BD subjects had higher rates of migraine headaches than HC (p = 5 × 10−3), but not cardiovascular disease (p = .08) or diabetes (p = .25) after adjusting for age, sex, BMI, and marital and employment/student status. Rates of past history of alcohol use disorders, past history of drug use disorders, and lifetime anxiety disorders (obsessive-compulsive disorder, panic disorder with or without agoraphobia, social phobia, specific phobia, agoraphobia without panic) were 36%, 17%, and 20%, respectively, in the BD group. BD subjects reported a lifetime history of rapid cycling (29%), suicide attempts (33%), and psychosis (59%). A history of mixed episodes, defined by the DSM-IV-TR definition of concurrent manic and depressive episode at the same time, was present in 23% of the sample, and that of mixed symptoms, defined as the presence of subsyndromal manic symptoms during depression or subsyndromal depressive symptoms during mania, was present in 36% of the sample. The average age at onset of BD was 19.2 ± 8.3. The number of episodes was highly skewed to the right, and the BD sample had a median of 5 depressive episodes, 2 manic episodes, and 3 hypomanic episodes. Even in this euthymic sample, current depressive and manic symptoms were higher in the BD than in the HC group (p < 1 × 10−3).
BD subjects had poorer sleep quality relative to HC subjects as measured by the PSQI total score as well as the subscales of sleep quality, sleep latency, sleep disturbance, sleep medication, and daytime dysfunction due to sleepiness (p < .01). Two of the scales did not differ, including sleep duration (p = .19) and sleep efficiency (p = .42). Sleepiness was also elevated in the BD group as measured by the Epworth Sleepiness Scale (ESS; p = .01). Chronotype did not differ between the BD and HC groups (p = .40).
Five-factor personality traits that differed in the BD group included elevated neuroticism and openness and lower conscientiousness (p < 7 × 10−3). The BD group had higher levels of childhood trauma (p < 1 × 10−3). The BD group reported higher levels of undesirable events in the last 6 months (p = 3 × 10−3), but the total number of stressful life events did not differ between BD subjects and HCs (p = .74). Family cohesion was lower in the BD group (p < 1 × 10−3), and family adaptability was lower as well (p = .03). Social support was significantly lower in the unadjusted pairwise comparison (unadjusted p = 4 × 10−3); however, no difference was detected when adjusted for age, sex, BMI, and marital and employment/student status (p = .12). Social undermining was higher in the BD group (p = 2 × 10−3). Current use of alcohol did not differ between groups (unadjusted p = .28); however, current use of drugs and nicotine was higher in BD (unadjusted p < .04).
Correlates of sleep quality in HC subjects
Sleep quality was correlated with demographic and clinical variables in the HC group first through the use of Pearson's r. Variables that were significantly correlated with poor sleep quality included being married (r = .28, p = 1 × 10−3) and Measures Related to Close Interpersonal Relationships (MRCIR) Undermining Scale (r = .25, p = 3 × 10−3). There was a trend for association with neuroticism (r = .16, p = .07) and current depressive symptoms (HDRS 21 with atypical, r = .17, p = .05). Age (r = .12, p = .18) and female gender (r = −.11, p = .90) were not associated with sleep quality in HC. To determine independent correlates of sleep quality, variables that were correlated in bivariate comparisons were then included in a series of multivariable linear regression models. The final model was chosen through a backward selection process. MRCIR social undermining was determined to be an independent predictor of sleep quality (Β = .20, p = .02) when controlled for marital status and current depressive symptoms (F = 6.74, df = 3, p < 1 × 10−3; adjusted R2 = .12).
Correlates of sleep quality in euthymic BD subjects
To determine independent predictors of sleep quality in a euthymic BD sample, clinical variables of interest were first tested with sleep quality in bivariate correlations. Significant correlates at the bivariate level were included in multivariable regression models by domain, and then a unified multivariable model was created that included all significant correlates from the models by domain (Table 4). In the models by domain, current depressive symptoms were significantly associated with poor sleep quality in each model except personality features. Current depressive symptoms dropped out of the final unified model.
In the final unified model, independent correlates of sleep quality in the BD group included rapid cycling (β = .20, p = .03), undesirable events (β = .20, p = .02), and neuroticism (β = .28, p = 2 × 10−3) (Table 4, Figure 1). Of the features of illness, suicide attempts were the most strongly correlated with sleep quality in the bivariate correlations, and remained significant in the model within the features of illness domain, but dropped out of the unified model. Mixed episodes were also significant in the bivariate correlations, but not in either the features of illness domain model or the unified model. Suicide attempts and rapid cycling were correlated with each other (r = .31, p = 1 × 10−3), and suicide attempts and mixed episodes were correlated with each other (r = .32, p = 1 × 10−3); however, rapid cycling and mixed episodes were not correlated (r = .13, p = .17). In the life story realm, Life Events Occurrence Survey (LEOS) undesirable events was the strongest correlate in the model by life story domain and remained significant in the unified analysis. Neuroticism was the strongest correlate in the personality assessment domain and in the unified analysis as well.
The only sociodemographic factor that was significant was marital status, but it did not enter into the final model after adjusting for other significant correlates.
Cardiovascular (p = .08) and drug use disorders (p = .07) were marginally associated with poor sleep quality in the comorbidity domain. In the severity of illness domain, age at onset of BD was significant in the bivariate correlations, and at the domain level, but dropped out of the unified model. Chronotype was also significant at the domain level, but was not present in the unified model.
In this study of euthymic patients with BD, correlates of poor sleep quality independent from residual depressive symptoms were examined in multiple domains that might be expected to affect sleep quality, including sociodemographic factors, medical and anxiety disorder comorbidities, features of BD, severity/symptom measures, chronotype and sleepiness, personality, life story/trauma, and behavioral factors. When domain-wide predictors were included in a final model, independent predictors of poor sleep quality in the BD sample included rapid cycling, high neuroticism, and undesirable events in the past 6 months, and those in the HC sample included social stress.
We can conceptualize poor sleep quality during euthymia in five ways: (1) as a causative trigger for a new mood episode, (2) as a prodromal sign or early symptom of a new mood episode, (3) as a residual symptom of a remitted mood episode, (4) as a distinguishing characteristic of a bipolar phenotype, and (5) as a comorbid sleep disorder/condition. By restricting the analysis to patients in a euthymic period, we designed our approach to study sleep quality as a characteristic of bipolar disorder. Though these subjects were in a traditionally defined ‘euthymic’ period, there was a range of subsyndromal symptoms in this population, consistent with a number of other studies indicating that subsyndromal depressive symptoms are common and predict recurrence (Perlis et al. 2006). The prevalence of subsyndromal symptoms such as poor sleep quality has led some groups to refer to periods without major mood episodes as ‘interepisode’ rather than euthymia (Harvey 2008). In our study, poor sleep quality was correlated with subsyndromal depressive symptoms in euthymic participants when not adjusted for other factors. However, when depressive symptoms were included with other factors affecting sleep quality, the correlation with depressive symptoms was lost, indicating that we found factors that affect sleep quality independently of subsyndromal symptoms. We continue to describe the cohort as euthymic to remain consistent with the bulk of the literature; however, the term interepisode should be considered. Whether poor sleep quality in this population is best categorized as prodromal or residual, treatment targeting the sleep quality outside of targeting depressive symptoms may reduce the substantial impairment and disruption in social and occupational functioning.
We found some consistencies between factors associated with poor sleep quality and psychological and environmental factors that are important predictors of sleep quality in the general population. In the HC group, social undermining predicted poor sleep, whereas in the BD group, association was found between poor sleep and neuroticism and stressful life events. Neuroticism is measured in the widely used five-factor model of personality developed by Costa and McCrae, which also measures extraversion (E), openness (O), agreeableness (A), and conscientiousness (C) (Costa and McCrae 1992). Neuroticism (N) measures the tendency to experience negative affects including fear, sadness, embarrassment, anger, and disgust. Individuals with BD have been shown to have elevated N and O, and low A, C, and E (Barnett et al. 2011). N marks a trait that has been associated with many psychiatric illnesses in addition to BD, including major depressive disorder, anxiety disorders, and personality disorders (Barnett et al. 2011; Costa et al. 2005; Middeldorp et al. 2011; Bagby et al. 2008; Bienvenu et al. 2004). Personality traits have high heritability and may predispose individuals to psychiatric illness; however, there is some indication that personality traits may be affected by psychiatric illness as well (Costa et al. 2005; Christensen and Kessing 2006). We believe that the association between poor sleep quality and neuroticism reported here is a general phenomenon which may be enhanced and exaggerated in BD patients, perhaps due to genetic predisposition, but is not unique to BD or to psychiatrically ill populations.
We found that poor sleep quality was associated with stressful events in euthymic BD and social stress in the HC group, which has also been found in general population samples (Fernandez-Mendoza et al. 2010b; LeBlanc et al. 2007). This is particularly important for BD because social stress has been shown to be greater in BD patients even when euthymic and was shown to be bi-directionally related to disturbed sleep (Eidelman et al. 2012). Affect reactivity in response to stress has also been shown to be greater in euthymic BD than in unipolar depressive disorder or controls (Knowles et al. 2007). Negative mood and sleep have also been shown to have a bi-directional relationship in a euthymic bipolar population; that is, negative mood in the evening may disturb sleep, and disturbed sleep may cause negative mood in the morning (Talbot et al. 2012). Close attention to the role of stress and mood reactivity is warranted in future studies of sleep quality in euthymic BD.
A history of rapid cycling was related to poor sleep quality in the euthymic BD group. Rapid cycling may be associated with sleep quality due to frequent cycling and short euthymic periods between episodes, and similar to stress reactivity, rapid cycling can be conceptualized as both a cause of poor sleep quality and a result of underlying poor sleep quality. In fact, rapid cycling may describe a distinct phenotype with biologically different properties driving both the mood and sleep disturbance. For example, rapid cycling has been linked to panic disorder in familial and genetic studies (MacKinnon and Zamoiski 2006;MacKinnon et al. 2003a, b) and has also been linked to low-activity risk alleles of the catechol-O-methyl transferase gene (Papolos et al. 1998;Kirov et al. 1998;Joyce et al. 1995) as well as abnormalities in the hypothalamic-pituitary-thyroid axis (Chakrabarti 2011). In addition, the hypothalamic-pituitary-adrenal (HPA) axis is an important modulator of sleep and the immune system and is abnormally activated in chronic insomnia (Vgontzas and Chrousos 2002;Vgontzas et al. 2004 2007;Basta et al. 2007). One pilot study has shown abnormally high cortisol and high cortisol response to the dexamethasone suppression test in five patients with rapid cycling, regardless of mood state (Watson et al. 2005). Underlying HPA axis dysfunction at baseline or in response to stress may link sleep quality, rapid cycling, and stress reactivity in BD. Rapid cycling is associated with the severity of BD illness and poor outcome (Schneck et al. 2004), and as has been shown in other studies, both rapid cycling and mixed episodes were highly correlated with suicide attempts (Coryell et al. 2003). In this sample, though both rapid cycling and mixed episodes were associated with suicide attempts, rapid cycling and mixed episodes were distinct from each other.
We did not find medical comorbidities, smoking, alcohol or drug use, or anxiety disorders to be significantly associated with sleep quality in HC or BD, when adjusting for other contributing factors. However, we had very few participants who reported active substance use, in part because active substance dependence was an exclusion criterion of the study. In our sample, HCs were younger and had a very low rate of CV disease. Cardiovascular disease and obesity have been associated with insomnia and overall poor sleep quality (Vgontzas et al. 2009a, b, c). In the BD sample, we found a significant association between sleep quality and cardiovascular disease in bivariate correlations and a trend toward association with obesity, but neither was significant in the final model. The domain-wide model identified cardiovascular disease as a stronger predictor of poor sleep quality than obesity.
Diagnosis of anxiety disorder did not affect sleep quality in the BD sample. Though this appears contradictory to the literature showing anxiety affects sleep quality (Fernandez-Mendoza et al. 2012a;Singareddy et al. 2012;Fernandez-Mendoza et al. 2012b), several factors may account for this lack of association. First, anxiety disorder comorbidity was half as common in this sample as other samples that were not restricted to euthymic patients, and in the Prechter cohort, if baseline mood is not restricted to euthymia, rates of anxiety disorders are very similar to published reports (Otto et al. 2006;Saunders et al. 2012). Because anxiety disorders are associated with worse course and severity of illness in BD (Goes et al. 2011;McLean et al. 2011;Saunders et al. 2012), they were underrepresented in our sample, which was restricted to euthymia. Two additional factors include the following: we did not have a systematic assessment of post-traumatic stress disorder (PTSD) included in anxiety disorders on all of our subjects, and we did not have a measurement of general anxiety outside of the specific anxiety disorders noted above. Future study of a measure of general anxiety may elucidate the relationship between anxiety and sleep in BD.
Though we did not have a measure of PTSD for all participants, we did examine the relationship between childhood trauma (CTQ), adult trauma (LEC), and poor sleep. Childhood trauma, but not adult trauma, was higher in the BD group, and associated with sleep quality in bivariate analysis, but recent undesirable events (LEOS) were a stronger predictor of poor sleep quality than childhood trauma in this sample. Recent stresses may have a stronger effect on sleep than childhood traumatic events due to the proximal temporal relationship. An alternate explanation is that individuals with BD who have recurring difficulties from trauma are continuing to have persistent depressive symptoms and may not be represented in this sample.
In the life story/trauma domain, raw scores for social support were lower in the BD group than in the HC group, but this difference was not significant after adjustment for age, sex, BMI, and marital and employment/student status; however, social undermining remained significantly higher in the BD group than in the HC group. This could be due to several reasons - the HC group is much younger, which was likely the reason for fewer marriages in this group. Thus, the BD group may have more individuals who are married, but fewer are employed or students, and may have a restricted social circle, and the marriage may not be a supportive one, but more of the HC are students with a social network.
We expected to find significant differences in sleep quality between women who had undergone menopause and those who have not, as previous population-based studies have shown (Chung and Tang 2006;Blumel et al. 2012;Monterrosa-Castro et al. 2012). One explanation is that the influence of BD on sleep quality may be more important than the effect of menopause; thus, no difference was detected in BD between women pre- and post-menopause. However, in this study, we had only self-reports of menopause, which may mean that peri-menopausal women are included in the pre-menopausal sample.
Limitations of this study include the subjective and retrospective nature of the PSQI. The PSQI measures an aggregate of sleep quality that includes many dimensions that are influenced by many factors, including the use of medications to promote sleep (Buysse et al. 1989). The use of medication may affect the presentation of BD, and thus, it is important to ask how the use of medication may have affected the variables examined in this study. Rapid cycling has been linked to antidepressant use in some studies (Fountoulakis et al. 2013); however, in this sample of euthymic BD subjects, antidepressants were used by a quarter of the participants (n = 31) at baseline, and the use was not correlated to the PSQI score (r = .03, p = .76), neuroticism (r = .08, p = .40), rapid cycling (r = .07, p = .46), or stressful events (r = .01, p = .95). An additional limitation includes the lack of objective physiological measures of physical health other than BMI. The contribution of cardiovascular or physiological measures that may contribute to poor sleep quality is likely underestimated in this study. In addition, our control group was younger than the BD group. However, we adjusted for age when comparing the HC and BD groups. The study strengths include a large sample of patients with well-characterized BD, as well as dimensional measures of sleep, personality, psychosocial stress, and behavioral measures.
Poor sleep quality is associated with depressive and manic episodes but often persists between episodes. Treatment of poor sleep quality between episodes is a frequent clinical problem, and targets for improving sleep quality, in addition to targeting residual mood symptoms, may improve outcomes in BD. Here, we present correlates of poor sleep quality that may be used to target treatments. Clinicians should remain vigilant for treating subjective sleep complaints independent of mood complaints in BD patients sensitive to poor sleep quality, including individuals with high neuroticism and rapid cycling. Reactivity to stressful life events during euthymia can be a target for psychotherapy, and modification may improve stress response. Association between poor sleep quality and rapid cycling emphasizes the importance of treatment of frequently cycling moods and improving sleep quality as mood and sleep quality each impact each other. BD patients with recent life stressors, history of rapid cycling, and high neuroticism are at elevated risk of experiencing poor sleep quality. Areas for further study include identifying correlates of specific subjective sleep complaints and using a home-based objective sleep measure such as actigraphy to describe sleep-related risk factors for poor outcome in BD (Faurholt-Jepsen et al. 2012;Kaplan et al. 2012;Jones et al. 2005).
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We would like to thank the participants in the Prechter Longitudinal Study of Bipolar Disorder, without whom this work would not be possible. We would also like to thank the dedicated research team of the Prechter Bipolar Group. Support was provided by the Heinz C. Prechter Bipolar Research Fund - University of Michigan and KL2 (KL2RR033180, EFHS). The Prechter Fund was not directly involved with the collection, analysis, and interpretation of data, in the writing of the manuscript, or in the decision to submit the manuscript for publication.
E. Saunders, D. Novick, J. Fernandez-Mendoza, M. Kamali, K. Ryan, and S. Langenecker declare that they have no competing interests. M. McInnis received honoraria for speaker's bureau from Merck Pharmaceuticals. A. Gelenberg has consultantship with Zynx, received an investigator-initiated grant through Penn State from Pfizer Pharmaceutical, and has major stock ownership in Healthcare Technology Systems, Inc.. None of these disclosures impact the content of this article.
ES designed the study, acquired the data, analyzed and interpreted the data, and drafted and revised the manuscript. DN, MK, KR, SL, and MM contributed to study design, data acquisition, data interpretation, and revisions of the manuscript. JF-M contributed to study design, data analysis and interpretation, and revisions of the manuscript. AG contributed to study design, data interpretation, and revisions of the manuscript. All authors have given final approval of the version to be published.
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